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Goodpasture disease (GP) is defined by the presence of anti-glomerular basement membrane (anti-GBM) antibodies and rapidly progressive glomerulonephritis. Besides anti-GBM, many patients with GP produce anti-neutrophil cytoplasmic antibodies (ANCA). For elucidation of the pathophysiologic significance of ANCA in this setting, epitope and antigen specificity of the anti-GBM antibodies and antigen s
The Triassic-Jurassic (Tr-J) boundary marks a major extinction event, which (similar to 200 Ma) resulted in global extinctions of fauna and flora both in the marine and terrestrial realms. There prevail great challenges in determining the exact location of the terrestrial Tr-J boundary, because of endemism of. : and the scarcity of fossils in terrestrial settings leading to difficulties in linking
Terrestrial water storage (TWS) is a crucial indicator of regional water balance and water resources changes. Due to limited hydrological observations, we combined the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On (GRACE-FO) products using the Long Short-Term Memory (LSTM) neural network to monitor the TWS changes from April 2002 to March 2020 over the closed Qaidam Basin in
English is widely recognized as the language of science, and English-language publications (ELPs) are rapidly increasing. It is often assumed that the number of non-ELPs is decreasing. This assumption contributes to the underuse of non-ELPs in conservation science, practice, and policy, especially at the international level. However, the number of conservation articles published in different langu
The carotid-to-femoral pulse wave velocity, determined by pulse transit time (PTT) and distance, is a well-established measure of arterial stiffness and predicts adverse outcomes. However, its predictive value decreases with aging. To explore new risk indicator in the elderly, we investigated if the variation of carotid-to-femoral pulse wave velocity, registered as beat-to-beat variability of caro
Huvudregeln gällande en stats brukande av våld framgår av artikel 2(4) i Förenta nationernas stadga. Av artikeln så framgår ett förbud för såväl hot som bruk av våld. Då det görs i syfte att inskränka en annan stats politiska oberoende eller territoriella integritet. Till detta så förbjuds även sådana hot eller bruk av våld som kan anses vara oförenligt med Förenta nationernas värdegrund. Av artikArticle 2(4) of the Charter of the United Nations presents the general rule regarding states use of force in international relations. The article states that all members are obliged to refrain from threat or use of force against another member states political independence or territorial integrity. Additionally, actions of threats or use of force that are in violation of the purposes of the United
Under 1900-talet såg världen omfattande lidande bland mänskligheten i flera länder, vilka kulminerade i folkmord och massakrer under 1990-talet. Ett sätt som identifierades för att få ett slut på grymma brott var humanitära interventioner. En kommission, The International Commission on Intervention and State Sovereignty (ICISS), tillsattes år 2001 för att utreda begreppet. De presenterade i decembDuring the 20th century, the world saw humans suffering in many countries around the world. These sufferings ended in genocide and massacres during the 1990s. One way that was identified to end atrocity crimes was humanitarian interventions. A commission, The International Commission on Intervention and State Sovereignty (ICISS), was appointed in 2001 to investigate the concept. They presented a n
As information technology develops in the past decade, the digital society has affected every aspect of the social structure. The legal system faces the challenge in implementing the legal norms, yet the evolved architecture of technology in the digital society makes it difficult for the law to perform its function. One of the fields of challenge is legal protection of personal data. Legislat
Sektion 52 i Copyright Designs and Patents Act innebär att det upphovsrättsliga skyddet i Storbritannien, vilket garanterar upphovsmannen ett skydd för 70 år efter hans död, minskar till 25 år efter att verket satts på marknaden om det upphovsskyddade verket har massproducerats. Storbritanniens lagstiftning skiljer sig från regleringen i övriga Europa eftersom resterande länder inte har samma undaThe foundational copyright protection in the United Kingdom provides the creator with a protection of 70 years after the death of the creator. Section 52 of the Copyright Designs and Patents Act reduces the copyright protec-tion, if the piece has been mass produced industrially, to a protection of 25 years after the product has been put on the market. The British government has during 2013 decided
Climate change is a global and demanding issue, which affects all the states on the planet. The European Union has from the 90s been vigorously engaged in the international efforts to tackle climate change and even pursued to take on the leading role in the global climate regime. The two most anticipated UN conferences for combating climate change at the global level were the COP15 in 2009 and COP
Denna uppsats utreder allvarlighetskriteriet för situationer och åtal i internationella brottmålsdomstolen. Domstolen kom till för att förhindra straffrihet för de grövsta internationella brotten. Efter att domstolen började verka har flera situationer i världen uppmärksammats av domstolen. Åklagarkammaren väljer ut situationer och enskilda mål mot bakgrund av allvarlighetskriteriet. Flera exempeThis study examines the interpretation of the gravity criterion for situations and cases before the International Criminal Court (ICC or the Court). The Court was established to prevent impunity for the most serious crimes of international concern. Since the Court became operative it has dealt with several situations of mass atrocity. The OTP selects situations and cases according to their gravity
BACKGROUND: Endolichenic fungi are microbes that inhabit the thalli of lichens and produce various unique chemicals that can be used for pharmaceutical purposes.PURPOSE: This study screened a library of endolichenic fungal extracts to identify novel anticancer agents capable of suppressing the tumorigenicity of human cancer cells.METHODS: Active compounds were isolated from extracts of endolicheni
Climate warming is expected to accelerate glacier retreat and shift hydrological regime, which poses great threat to regional water resources in terms of amount, variability, and quality. This is especially true in arid regions with glaciers such as the Central Asia. However, few models manage to mimic both glacier runoff and surface changes with adequate performance.
The first authoritative overview of tourism studies published post-COVID-19 The Wiley Blackwell Companion to Tourism remains a definitive reference in this interdisciplinary field. Edited and authored by leading scholars from around the world, this state-of-the-art volume provides a comprehensive critical overview of tourism studies across the social sciences. In-depth yet accessible chapters comb
