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The pharmacologic and pharmacokinetic properties were evaluated in a series of antiuterotonic oxytocin analogs, modified at positions 1, 2, 4, 8 and, in one case, position 9 of the oxytocin (OT) molecule. [Mpa1,D-Tyr2(Et),Val4,Orn8,desGly9]-OT, [Mpa1,Tyr2(Et),Val4,Orn8]-OT and [Mpa1,D-Tyr2,Val4,Orn8]-OT displayed similar plasma clearance rates (Clps) using the constant infusion method in rats. Two
This thesis examines the potential constitutional restrictions that may prevent Costa Rica from introducing a Qualified Domestic Minimum Top-Up Tax (QDMTT) into its legislation, specifically targeting in-scope Constituent Entities operating under the country’s Special Tax Regime. The main research question explores whether the constitutional principles of non-retroactivity and legitimate expectati
This thesis investigates ecocide as a form of environmental violence by state and non-state actors, reframing ecological destruction as a political and antagonistic act rather than an accidental byproduct of development. This research emphasises the active participation of state institutions in facilitating and perpetuating large-scale environmental harm while deterring efforts to legally frame ec
The chirality-flow formalism has proven to simplify the calculations of helicity amplitudes to the extent that the matrix element corresponding to a Feynman diagram can immediately be written down. It has also shown to speed up the computation of scattering amplitudes through numerical implementations in MadGraph5_aMC@NLO. In this thesis we investigate if automated computation of amplitudes can be
This thesis examines whether the current EU competition law framework, particularly Articles 101 and 102 TFEU, is sufficient to regulate algorithmic collusion. As pricing algorithms become more autonomous and capable of producing supra-competitive outcomes without direct human input, concerns arise about whether such behaviour fits within existing legal categories like “concerted practice” or “abu
The top European football leagues are generating billions of euros in revenues each season and the selling of broadcasting rights is their primary source of income. The selling arrangements for these rights have been under investigation by competition authorities and the European Commission has ruled some of the practices to be in breach with European competition law. In the case of English Premie
On January 4th, 2022, new restrictions under the Europe-wide REACH protocol on chemicals hit the tattooing industry when the content of inks came under regulation. This essay seeks to find out how this directly has impacted tattoo artists and their ability to work. To achieve this a phenomenological approach was used, and data was collected through six semi-structured, qualitative interviews with
Emergency planning is required to respond to the increasing wildfire threat. A part of this is to assess a community’s capacity to move to a safe place during wildfires. This can be achieved by calculating the time it takes for a community to evacuate from an at-risk area to a relatively safe place. Simple approaches, such as the commonly used engineering calculation, may provide access to a broad
This paper uses variation of education generated by the interaction of compulsory schooling laws and season of birth as an instrument to estimate the effect of education on mortality and self-reported health. Education is found to have protective effects on health which differ between cohorts. Threats to this in the literature common approach are identified and the following analysis implies that
Background: Music festivals are known to attract a high proportion of drug users. Methods: Using a survey of 1,772 visitors at the Roskilde Festival in Denmark, we assessed substance use at the festival, the incidence of use of substances among never-users and the incidence of use among lifetime users who had not used a substance in the past 12 months. Results: New onset of tobacco use was reporte
Throughout time, communities have adapted to changes in their environment and, in doing so, have addressed risksthat threaten the things they value. The need to adapt is considered more urgent now than ever, notably given thecurrent focus on climate risk. Typically, adaptation is presented as a solution to reduce such risks. This is particularlythe case for Landlocked Developing Countries and Smal
Attempts to measure the capitalization of local taxes into property prices, starting with Oates (1969), have suffered from a lack of local public service controls. We revisit this vast literature with a novel dataset of 947 time-varying local characteristic and public service controls for all municipalities in Sweden over the 2010-2016 period. To make use of the high dimensional vector of control
Molecular characterization of measles virus was part of the epidemiological investigation of 27 measles cases reported in Denmark in 2006. RT-PCR detected measles virus RNA from various types of clinical specimens in 24 cases. Virus genotypes were determined by sequencing the nucleocapsid (N) gene. Four different genotypes, B3, D4, D5 and D9 were identified including two variants of the D4 genotyp
Free-electron lasers are capable of producing high-quality radiation in a wide wavelength range and at very high power and brilliance. To reach improved performance especially regarding coherence, bandwidth and wavelength stability, different seeding techniques are often required. However, a successful implementation of seeding typically demands a very high-quality electron beam, in terms of energ
Many Fusarium species cause serious diseases for cereal cultivation. These include Fusarium head blight and crown rot on wheat and bakanae disease on rice. These represent a major concern both in terms of food security and food safety. The latter is connected with the risk of mycotoxin contamination of grains. Biological control has proven its potential for controlling head blight and crown rot di
We derive the expression of the loop gain in a circuit containing one or more feedback loops, where the transfer functions building the expression are found by means of a few AC analyses on the circuit. No approximations or assumptions on the nature of the loop or of the impedances therein contained are necessary. While hand calculations are certainly possible in the case of simpler circuits, the
Business angels are a vital source of capital for innovative start-up firms. However, many potentially attractive investment opportunities are rejected during the angel's decision-making process. Information asymmetry, risk and distrust in the relationship between the investor and the entrepreneur result in investment barriers. The concept of proximity has been proposed as a conceptual foundation
In this study of the effects of lead on the endocrine system, 77 secondary lead-smelter workers (i.e., 62 active and 15 retired) were compared with 26 referents. Lead concentrations were determined in plasma with inductively coupled plasma mass spectrometry (i.e., index of recent exposure), in blood with atomic absorption spectrophotometry, and in fingerbone with K x-ray fluorescence technique (i.
