Filetype
To test the hypothesis that the A/T polymorphism of the fatty acid-binding protein 2 gene (FABP2) is associated with impaired lipid metabolism and cardiovascular disease, we compared clinical characteristics and a parental history of cardiovascular disease between 213 sibling pairs discordant for the polymorphism. Siblings with an excess of the T54 allele had higher triglyceride (P = 0.002) and ch
Reduction of energy use in buildings is fundamental for sustainable development. A computer program for the prediction of energy use in buildings was assessed by comparisons with the energy performance of existing buildings. The program was then used to evaluate the energy saving characteristics of concrete such as air tightness and heat capacity. The impacts on global environmental aspects and li
Human cystatin C variants in which the evolutionarily conserved Gly-11 residue has been replaced by residues with positively charged (Arg), negatively charged (Glu), bulky hydrophobic (Trp), or small (Ser or Ala) side-chains have been produced by site-directed mutagenesis and expression in Escherichia coli. The five variants were isolated and structurally verified. Their inhibitory properties were
This review aims to sum up current knowledge on the sensitivity and specificity of ultrasound features suggestive of acute pelvic inflammatory disease (PID).
Satellite remote sensing has the potential to contribute to plant phenology monitoring at spatial and temporal scales relevant for regional and global scale studies. Historically, temporal composites of satellite data, ranging from 8 days to 16 days, have been used as a starting point for satellite-derived phenology data sets. In this study we assess how the temporal resolution of such composites
Based on a realist conceptualization of interests, this paper explores how commercial and scientific priorities appear to have converged and diverged during the development of the antidepressant Zelmid. The drug represents the first of the selective serotonin reuptake inhibitors (SSRIs) to reach the market. Zelmid was synthesized in 1971 and launched by the Swedish firm Astra in 1982, but subseque
This Letter reports on a systematic study of β-decay half-lives of neutron-rich nuclei around doubly magic ^{208}Pb. The lifetimes of the 126-neutron shell isotone ^{204}Pt and the neighboring ^{200-202}Ir, ^{203}Pt, ^{204}Au are presented together with other 19 half-lives measured during the "stopped beam" campaign of the rare isotope investigations at GSI collaboration. The results constrain the
In the first of two essays in this Journal, I seek to unify the historical geography of early modern 'European expansion' (Iberia and Latin America) with the environmental history of the 'transition to capitalism' (northwestern Europe). The expansion of Europe's overseas empires and the transitions to capitalism within Europe were differentiated moments within the geographical expansion of commodi
Although case studies exist of the influence of non-governmental organisations in international environmental negotiations, theoretical conclusions remain scattered, and the separation in previous literature between the study of environmental non-governmental organisations (ENGOs) and business and industry non-governmental organisations (BINGOs) reduces the generalisability of conclusions. The con
In this work, a first-order upwind and a high-order flux-limiter schemes for solving the advection–diffusion equation on unstructured grids were evaluated. The numerical schemes were implemented as a module of an unstructured two-dimensional depth-averaged circulation model for shallow lakes (IPH-UnTRIM2D), and they were applied to the Guaíba River in Brazil. Their performances were evaluated by c
Patterns of selection acting on immune defence genes have recently been the focus of considerable interest. Yet, when it comes to vertebrates, studies have mainly focused on the acquired branch of the immune system. Consequently, the direction and strength of selection acting on genes of the vertebrate innate immune defence remain poorly understood. Here, we present a molecular analysis of selecti
With an integrated luminosity of 2.47 fb^{-1} recorded by the ATLAS experiment at the LHC, the exclusive decays B_{s}^{0}→J/ψϕ and B_{d}^{0}→J/ψK^{*0} of B mesons produced in pp collisions at sqrt[s]=7 TeV are used to determine the ratio of fragmentation fractions f_{s}/f_{d}. From the observed B_{s}^{0}→J/ψϕ and B_{d}^{0}→J/ψK^{*0} yields, the quantity (f_{s}/f_{d})[B(B_{s}^{0}→J/ψϕ)/B(B_{d}^{0}→
This article investigates the impact of labour mobility on plant performance in Denmark. Our study shows that the effect of labour mobility can only be assessed when one accounts for the type of skills that flow into the plant and the degree to which these match the existing skills at the plant level. As expected, we found that the inflow of skills that are related to skills in the plant impacts p
Extensive published evidence supports the use of subcutaneously-administered apomorphine as an effective therapy for Parkinson's disease (PD) but to date no consensus recommendations have been available to guide healthcare professionals in the optimal application of apomorphine therapy in clinical practice. This document outlines best-practice recommendations for selecting appropriate candidates f
Visceral leishmaniasis (VL) is a potentially fatal vector-borne zoonotic disease, which has become an increasing public health problem in the north-western part of Iran. This work presents an environmental health modelling approach to map the potential of VL outbreaks in this part of the country. Radial basis functional link networks is used as a data-driven method for predictive mapping of VL in
This paper deals with knowledge flows and collaboration between firms in the regional innovation system of southern Sweden. The aim is to analyse how the functional and spatial organization of knowledge interdependencies among firms and other actors varies between different types of industries that draw on different types of knowledge bases. We use data from three case studies of firm clusters in
