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The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to UV-B irradiation and cellular differentiation. Promoter activities were higher in

There is ample evidence for intra-patient evolution of the human immunodeficiency virus type 1 (HIV-1) biological phenotype during the pathogenic process. Evolution often involves switch of coreceptor use from CCR5 to CXCR4, but change to more flexible use of CCR5 occurs over time even in patients with maintained CCR5 use. The increasing use of entry inhibitors in the clinic, often specific for on

Capacity development for disaster risk reduction is an important process to substantially reduce disaster losses, which threaten sustainable development and the achievement of the Millennium Development Goals. This paper presents a theoretical framework with seven elements for capacity development for disaster risk reduction that has been tested in practise with noteworthy results. The seven eleme

The purpose of this study is to elucidate affordances and meaning-making processes where students in Compulsory lower secondary education learn to play music together in music class. The data consists of a series of observed music lessons, performances and stimulated recall interviews in two 8th form classes, video recorded in the course of one term. The analysis focuses on students’ and their tea

The idea of the 'Swedish model' has been a widespread and enduring concept in the social sciences since the 1930s, associated with the political dominance of the Social Democratic Party, peaceful social development and a tradition of political consensus. Taking this exceptionalism as their starting point, the essays in this volume present new research on Swedish political movements of the nineteen

This paper describes a case of collaboration between academia and business firms in supporting innovation processes based on the CILO method, named after the CILO project (communication in learning organizations). The CILO method is an example of firm-supportive research approach. We describe the outcomes related to enhancing enterprise performance from applying the CILO-method in relation to one

CONTEXT: Early prediction of dysglycemia is crucial to prevent progression to type 2 diabetes. The 1-hour postload plasma glucose (PG) is reported to be a better predictor of dysglycemia than fasting plasma glucose (FPG), 2-hour PG, or glycated hemoglobin (HbA1c). OBJECTIVE: To evaluate the predictive performance of clinical markers, metabolites, HbA1c, and PG and serum insulin (INS) levels during

The current and future strength of the terrestrial carbon sink has a crucial influence on the expected climate warming on Earth. Usually, Earth Observation (EO) by its very nature focusses on diagnosing the current state of the planet. However, it is possible to use EO products in data assimilation systems to improve not only the diagnosis of the current state, but also the accuracy of future pred

Taking a psychological and philosophical outlook, we approach making as an embodied and embedded skill via the skilled artisan’s experience of having a corporeal, nonlinguistic dialogue with the material while working with it. We investigate the dynamic relation between maker and material through the lens of pottery as illustrated by wheel throwing, claiming that the experience of dialogue signals

A modern hearing aid should be aesthetically appealing as well as offer sufficient and adequate signal amplification. Due to the small physical size of these devices, acoustical feedback (howling) is a major problem. Apart from the annoyance and potential hearing damaging effects that howling implies, it also reduces the supplied maximum Real Ear Aided Gain (REAG). This paper proposes a novel method

Combinations of genetic and environmental factors contribute to the pathogenesis of type 2 diabetes (T2D); however, our knowledge of the molecular mechanisms by which these factors trigger diabetes is still limited. While genome-wide association studies have identified and characterized more than 60 genomic loci associated with T2D, recent methylome charts and reference regulatory maps obtained fr

Persuasion and manipulation have been central concerns of Critical Discourse Analysis since its beginnings (e.g. Hart 2014; Van Dijk 1996). Traditionally, the persuasive and manipulative potential of texts has been explored by means of interpretive analysis. However, the actual perlocutionary effects of the strategies identified through this process are rarely (if ever) evaluated empirically. This

We argue that wars over natural resources, even if they are limited in their military scope, can have long-term consequences on the level and composition of public revenues. Military success in a resource war may lead to the annexation of natural resource-rich areas from enemy combatants, which provides the winning coalition with valuable and easy-to-tax sources of income. This, however, might dis

The White House Budget proposal for 2018, if approved, could lead to a drastic cut in US funding of UN activities in the coming years. Since the US is the largest contributor to the regular budget, peacekeeping operations, agencies and programmes, its decision could have major implications on the organisation’s workings. Besides well-founded queries about what the US actually stands to gain by suc

There is an urgent need to address in a comprehensive manner the problem of systematic and flagrant violations of international humanitarian and human-rights law in ongoing conflicts, including its sources and implications. More specifically, possible lines of action to counter the growing importance of non-state armed actors and the use of explosives in populated areas must be discussed. A Global

Fatigue is one of the principal damage mechanisms in a slender concrete structure under cyclic loads. And needs to be calculated locally through all the structure, considering the lading conditions and the particularities of concrete. The model presented here is capable to account for the fatigue damage in a probabilistic way, relating the annual loading conditions for each point and the degradati

The rich vacuum structure of multi-Higgs extensions of the Standard Model (SM) may have interesting cosmological implications for the electroweak phase transition (EWPT). As an important example of such class of models, we consider a particularly simple low-energy SM-like limit of a recently proposed Grand-Unified Trinification model with the scalar sector composed of two Higgs doublets and a comp