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OBJECTIVE-Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired beta-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS-We have conducted a meta-analysis of genome-wide as
OBJECTIVE-A genome-wide association study (GWAS) in Pima Indians (n = 413) identified variation in the ataxin-2 binding protein 1 gene (A2BP1) that was associated with percent body fat. On the basis of this association and the obese phenotype of ataxin-2 knockout mice, A2BP1 was genetically and functionally analyzed to assess its potential role in human obesity. RESEARCH DESIGN AND METHODS-Variant
Intraneuronal inclusions containing alpha-synuclein (a-syn) constitute one of the pathological hallmarks of Parkinson's disease (PD) and are accompanied by severe neurodegeneration of A9 dopaminergic neurons located in the substantia nigra. Although to a lesser extent, A10 dopaminergic neurons are also affected. Neurodegeneration of other neuronal populations, such as the cholinergic, serotonergic
1. A new methodological approach for detailed study of the organization of the cerebellar corticonuclear projection was evaluated in barbiturate-anaesthetized cats. Extracellular field potentials were simultaneously recorded in nucleus interpositus anterior and in the forelimb area of the C3 zone, at the cerebellar surface. On electrical and natural stimulation of the forelimb skin, the evoked pos
We have developed a combinatory antibody-antigen microarray for direct screening of multiple single-chain fragment variable (scFv) clones with no need for pre-purification or enrichment before screening. The straightforward workflow allows for early selection of binders to predefined peptide and glycopeptide targets. A capture antibody is contact printed on microarray slides, side by side with the
In this study, we report the suppression of degradative transformations observed in Na-ion batteries by utilizing five different transition-metal cations at a single crystallographic site, which is expected to impart entropy-induced stabilization, resulting in enhanced structural stability. We successfully synthesized phase-pure O3-NaTi0.2Mn0.2Fe0.2Ni0.2Co0.2O2 through a facile solid-state sinteri
BACKGROUND: Proteinuric glomerular diseases often are associated with tubulointerstitial injury, which imposes on the progression of renal failure. Tubular damage is partly referable to toxic effects on the tubular epithelial cells induced by filtered plasma proteins. Patients with nonselective proteinuria, that is, increased urine excretion of high-molecular-weight plasma proteins such as IgG in
A 10-bit, 100-MHz CMOS linear interpolation digital-to-analog converter (DAC) is presented. It includes a 16-tap voltage controlled delay line and a 10-bit binary-weighted DAC with a time-interleaved structure. The linear interpolation not only increases the attenuation of the DAC's image components, but also reduces the glitch of the binary-weighted DAC. The requirement for the analog reconstruct
Första delen i denna avhandling fokuserar på 'Imaging Mass Spectrometry' (IMS), en analytisk teknik med kartografiska egenskaper. Denna teknik används dock inte för att kartlägga geografiska terränger, utan för att skapa kartor över det kemiska landskapet i biologiska prover, från vävnadssnitt av organ eller tumörer till enskilda celler. Dessa kartor visar med hög precision var olika molekyler, såThe development of imaging technologies and brain models is crucial for advancements in neurotherapeutic drug discovery and development. They assume a critical role in evaluating essential parameters such as drug blood-brain barrier (BBB) permeation, distribution, and metabolism, all of which are vital for the development of safe and effective medications. In the first part of this thesis, we expl
Large intelligent surface (LIS) is a technology that extends massive MIMO by considering an even greater number of antennas distributed throughout vast areas. In order to be able to implement this technology, it is crucial to consider decentralized architectures so as to make the whole system scalable. We consider a LIS divided into several LIS panels of smaller size, which can be located far away
BACKGROUND: Extensive head and neck reconstructive surgery is a complex procedure often performed in patients with multiple comorbidities, and the risk of complications is high. Evidence-based preoperative assessment and reliable risk prediction are therefore essential, and the anesthesiologist plays an important role in this process. The aim of this study was to evaluate the predictive properties
Agenda 2030 Graduate School monthly newsletter #4 2024-04-09 Ylva van Meeningen Good morning! It seems to be so much celebration this month connected to the graduate school. The Agenda 2030 award, several defences coming up and a general buzz within nature itself. It is on days like this one, where you regret deeply why you decided to put on your winter coat and boots on such a warm shiny day, tha
Welcome Address of the General Chairs of the QMOD Conference Jens J. Dahlgaard Dr. Professor Linköping University Su Mi Dahlgaard-Park Dr. Professor Lund University It is our great pleasure to welcome all participants from about 30 countries and 5 continents to the 19th QMOD/ICQSS conference. The conference has attracted contributions from relevant fields of management, engineering, marketing etc.
https://www.ses.lu.se/en/sites/ses.lu.se.en/files/qmod_2016_full_program_1.pdf - 2026-10-06
Negation on the Move: The Pragmatics of Negative Preposing in Icelandic * Elena Callegari Ásgrímur Angantýsson University of Iceland Abstract This paper explores the syntactic and pragmatic constraints on Negative Preposing (NP) in Ice- landic, with a focus on the preposing of negation in finite clauses with an overt subject. While negation in Icelandic typically appears post-verbally, we show tha
Ensuring Climate Justice in the Asia Pacific - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law - Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluat
https://rwi.lu.se/2018/02/23/ensuring-climate-justice-asia-pacific/ - 2026-10-05
Masterprogram matematisk statistik | Matematikcentrum Hoppa till huvudinnehåll Den här webbplatsen använder cookies för att förbättra användarupplevelsen. Genom att fortsätta använda webbplatsen samtycker du till att cookies används enligt vår cookie-policy (på LTH:s webbplats) . Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera och kan inte stängas av i våra s
https://www.maths.lu.se/utbildning/masterprogram/masterprogram-matematisk-statistik/ - 2026-10-05
Patrik Medstrand Professor Read about Patrik in the Research Portal Patrik´s publications Sara Karlson Senior Laboratory Assistant MSc. Biomedicine Read about Sara in the Research Portal Sara's publications " HIV research has always been very intriguing to me and this contributes to my long-term interest in the field. Working as a lab technician for three dif
https://www.virology.lu.se/clinical-virology/clinical-virology-team - 2026-10-05
Professor Kontaktinformation E-post: raimund [dot] muscheler [at] mgeo [dot] lu [dot] seOrganisation Miljö- och geovetenskapliga institutionen (MGeo) Hämtställe: 16 WebbplatsRaimund Muschelers profil i Lunds universitets forskningsportalAndra roller Medlem i Strategiskt forskningsområde BECC: Biodiversity and Ecosystem services in a Changing Climate Medlem i Strategiskt forskningsområde MERGE: Mod
https://www.mgeo.lu.se/raimund-muscheler - 2026-10-05
Professor Kontaktinformation E-post: martin [dot] berggren [at] mgeo [dot] lu [dot] seOrganisation Miljö- och geovetenskapliga institutionen (MGeo) Hämtställe: 16 WebbplatsMartin Berggrens profil i Lunds universitets forskningsportalAndra roller Studierektor för forskarutbildningen Miljö- och geovetenskapliga institutionen (MGeo) Medlem i Strategiskt forskningsområde BECC: Biodiversity and Ecosyst
https://www.mgeo.lu.se/martin-berggren - 2026-10-05
