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Background: Human breast tissue undergoes phases of proliferation, differentiation and regression regulated by changes of the levels of circulating sex hormones during the menstrual cycle or aging. Ovarian hormones also likely play a key role in the etiology and biology of breast cancer. Reports concerning the proliferative effects of steroid hormones on the normal epithelium of human breast have
Popular Abstract in English A handful of diseases-causing pathogenic microorganisms claim millions of lives worldwide each year, mainly due to limited diagnostic capabilities. The lack of simple, cost-effective, sensitive and rapid on-site diagnostic tools lead to delays in the diagnoses with a subsequent lag in treatment, which in turn can result in serious complications or even loss of lives. Fast and sensitive detection of pathogenic microbial cells is a highly important task in medical diagnostics, environmental analysis and evaluation of food safety. Accordingly, the idea of microorganism identification by the recognition of specific DNA sequence using electrochemical technique is one of the leading researches in the development of diagnostic devices. In other words, it should only
The main idea of this paper is to use distances between camera positions to recover the trajectory of a mobile robot. We consider a mobile platform equipped with a single fixed camera using images of the floor and their associated inter-image homographies to find these distances. We show that under the assumptions that the camera is rigidly mounted with a constant tilt and travelling at a constant
Chronic hyperglycemia leads to pancreatic beta-cell dysfunction characterized by diminished glucose-stimulated insulin secretion (GSIS), but the precise cellular processes involved are largely unknown. Here we show that pancreatic beta-cells chronically exposed to a high glucose level displayed substantially increased amounts of stress fibers compared with beta-cells cultured at a low glucose leve
Feedback control is increasingly being applied in server systems to make them more robust and efficient. This includes managing quality of service, minimizing power consumption, and adapting to varying workloads. Successful adaptation and control in turn relies on accurate tracking of workload variations and timely detection of changes in the computing infrastructure. Given that server systems are
With shrinking technologies and higher clock rates comes the possibility to transform multi chip implementations to a single System on Chip (SoC). Implementing clock distribution and limiting the power consumption becomes increasingly troublesome with increased clock rate and chip area. Therefore, designing large Systems on Chip makes it necessary to search for new implementation methods. In this
VOR, the versatile optimal resolution chopper spectrometer, is designed to probe dynamic phenomena that are currently inaccessible for inelastic neutron scattering due to flux limitations. VOR is a short instrument by the standards of the European Spallation Source (ESS), 30.2m moderator to sample, and provides instantaneous access to a broad dynamic range, 1-120 meV within each ESS period. The sh
Robustness of distributed routing policies is studied for dynamical flow networks, with respect to adversarial disturbances that reduce the link flow capacities. A dynamical flow network is modeled as a system of ordinary differential equations derived from mass conservation laws on a directed acyclic graph with a single origin-destination pair and a constant inflow at the origin. Routing policies
Differences in morphologies of bacteria and bacteria clusters are thought to contribute to their virulence and colonization. However, the conventional standard cell biological methods cannot separate bacteria and bacteria clusters based on their morphologies and sizes, making studies of the underlying mechanisms difficult. Here we report a simple label-free method for the continuous separation of
Currently, the European Union (EU) is the “green leader”, globally, in adopting policies to support longer product lifetimes. One reason for this state of affairs is that EU Member States are adopting progressive policies, which put pressure on the EU to set EU-wide laws to replace national ones. The main reason for this situation is that national rules may lead to distortions in trade in the EU S
The aim of this study was to verify a novel volumetric arc therapy technique, RapidArc". Polymer gel dosimetry system was used to measure the advanced inhomogeneous 3D dose distribution produced using the technique RapidArc". A preclinical installation of the novel beam delivery approach was set up on a linear accelerator at Rigshospitalet in Copenhagen. A prostate treatment plan was delivered to
Having close-to-capacity performance and low error floor, even for small block lengths, make spatially coupled serially concatenated codes (SC-SCCs) a very promising class of codes. However, classical window decoding of SC-SCCs either limits the minimum block length or requires a large number of iterations, which increases the complexity and constrains the degree to which an SC-SCC decoder archite
This paper presents LuMaMi28, a real-time 28GHz multi-user (MU) multiple-input multiple-output (MIMO) testbed. In this testbed, the base station has 16 transceiver chains with a fully-digital beamforming architecture (with different pre-coding algorithms) and simultaneously supports multiple user equipments (UEs) with spatial multiplexing. The UEs are equipped with a beam-switchable antenna array
Materials with bimodal grain size distributions have an attractive combination of strength and ductility. Harmonic structure materials are a category of bimodal-structure materials with a specific microstructure design. The deformation mechanisms of such novel materials during the early stages of deformation are not well understood. Thus, we deformed nickel with harmonic structure in tension until
During evolution the human brain has increased drastically in size compared to that of other primates. However, little is known about primate brain development as it is difficult to study human and primate brains in the laboratory due to the scarcity of tissues. Yet, it is essential to study primate brains and understand the molecular features leading to the human brain’s unique cognitive function
Laser-based diagnostic techniques have been utilized to analyse a variety of processes, offering valuable insights on temperature and species concentrations with non-intrusive measurements, while maintaining high temporal and spatial resolution. With the advent of technology and the introduction of lasers with high peak power, such as femto-second (fs) lasers, the full potential of these diagnosti
Organ function depends on the three-dimensional integrity of the extracellular matrix (ECM). The structure resulting from the location and association of ECM components is a central regulator of cell behavior, but a dearth of matrix-specific analysis keeps it unresolved. Here, we deploy a high-resolution, 3D ECM mapping method and design a machine-learning powered pipeline to detect and characteri
Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia ARTICLE OPEN Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia Kärt Mätlik 1✉, Daniel R. Garton1,13, Ana R. Montaño-Rodríguez1,13, Soophie Olfat1,2,13, Feride Eren 3, Laoise Casserly1, Anastasios Damdim
Matchmaking contributions Content 1. Theme I: Knowledge on crisis and resilience in the sustainability context 2. Theme II: Knowledge on communicating uncertainty and ambiguity in sustainability research 3. Theme III: Knowledge about justice and equity in a sustainable world 4. Theme IV: Future Calls Matchmaking contributions Matchmaking event contribution Research Conference on Sustainable Develo
