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This article summarizes the contributions in this special issue on Diffraction-Limited Storage Rings. It analyses the progress in accelerator technology enabling a significant increase in brightness and coherent fraction of the X-ray light provided by storage rings. With MAX IV and Sirius there are two facilities under construction that already exploit these advantages. Several other projects are
AbstractThe high gray-white matter contrast and spatial resolution provided by T1-weighted magnetic resonance imaging (MRI) has made it a widely used imaging protocol for computational anatomy studies of the brain. While the image intensity in T1-weighted images is predominantly driven by T1, other MRI parameters affect the image contrast, and hence brain morphological measures derived from the da
Recent research in entrepreneurship has examined factors that could reduce the challenges facing new businesses (the so-called ‘liabilities of newness’). Seeking to contribute to this research, this study examines the potential role of a financial bootstrapping approach (finding ways of securing resources on favourable terms). Even though financial bootstrapping has received increased attention in
The rd1 natural mutant is one of the first and probably the most commonly studied mouse model for retinitis pigmentosa (RP), a severe and frequently blinding human retinal degeneration. In several decades of research, the link between the increase in photoreceptor cGMP levels and the extremely rapid cell death gave rise to a number of hypotheses. Here, we provide clear evidence that the presence o
In this communication, we analyse the passage of oxygen and carbon dioxide over the respiratory membrane. The lung surfactant membrane at the alveolar interface can have a very special arrangement, which affects the diffusional transport. We present a theoretical model for the diffusion of small molecules in membranes with a complex structure, and we specifically compare a membrane composed of a t
With the rapid progress in the development of new clinical biomarkers there is an unmet need of fast and sensitive multiplex analysis methods for disease specific protein monitoring. Immunoaffinity extraction integrated with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) analysis offers a route to rapid and sensitive protein analysis and potentially multiplex biomarker an
To examine if overall diet quality is associated with cellular and soluble biomarkers of systemic inflammation in middle-aged individuals.
Endothelin, a peptide produced in endothelial cells, was found to be a potent constrictor of human pial arteries through a direct, slow action on the smooth muscle cell, with a pD2 value of 8.54. It was less potent as a constrictor in pial veins (pD2 7.80) and in branches of the middle meningeal artery and superficial temporal artery (pD2 7.61 and 7.77). The major component of the contractile resp
This article describes a PIXE system designed and constructed for routine longitudinal scanning of single hair strands. In constructing a PIXE system for trace elemental scans of single hair strands on a routine basis, a fairly intense beam has to be used but the heating damage must be kept to a minimum. The experimental conditions (charge integration, beam homogeneity etc.) have to be carefully c
We present two-dimensional numerical simulations of a model for Kepler's supernova remnant (SNR) carried out with the YGUAZU-A code. Following previous studies, we have assumed that the peculiar shape of this young remnant arises as a consequence of the interaction of the SNR blast wave with the bow shock formed by the wind of its high velocity progenitor. Furthermore, from our numerical results w
Palladium supported on Si-stabilised alumina has been demonstrated to be an active and durable catalyst for the combustion of methane. Si is more effective in stabilising alumina than La or Ba when the elements are added through an impregnation technique. Multiple stabilisation with combinations of La, Ba and Si does not increase further the stability against sintering. The stability increases log
X-linked hyper-IgM syndrome (X-HIM) is an immunodeficiency caused by mutations in the gene encoding the CD40 ligand (CD40L). A database (CD40Lbase) of CD40L mutations has now been established, and the resultant information, together with other mutations reported elsewhere in the literature, is presented here.
Mammalian mitochondrial genomes are organized in a conserved and extremely compact manner, encoding molecules that play a vital role in oxidative phosphorylation (OXPHOS) and carry out a number of other important biological functions. A large-scale screening of the normalized mitochondrial gene expression profiles generated from publicly available mammalian serial analysis of gene expression (SAGE
To determine the stabilizing effect of external lumbar supports on the intervertebral mobility in the lower lumbar spine, seven patients with a posterolateral lumbosacral fusion without internal fixation were examined by roentgen stereophotogrammetric analysis in supine and erect positions 1 month after surgery, that is, after soft tissue healing but before fusion consolidation. Each patient was e
The first experimental study of focusing synchrotron radiation by a parabolic planar glassy-carbon lens is presented. The lens consists of four biconcave single lenses with a curvature radius of 0.2 mm and a relief height comparable with the lens aperture (similar to1 mm). One lens gives rise to the formation of a linear focus with a length comparable with the height of a parabolic profile. The us
The nominal species Mosasaurus ivoensis from the latest early Campanian of the Kristianstad Basin in southern Sweden, is redescribed and assigned to the tylosaurine genus Tylosaurus on the basis of its dental and vertebral morphology. A partial skeleton (KUVP 1024) from the late Coniacian to earliest Campanian Smoky Hill Chalk Member of the Niobrara Formation in western Kansas, USA, was previously
Multiconfigurational SCF and second-order perturbation theory have been employed to study seven low-lying electronic states of the CoC molecule (X-2 Sigma(+), A(2)Delta, B(2)Phi, C(2)Phi, D(2)Pi, E(2)Pi, and F(2)Sigma(+)). Three doublet electronic states have been described for the first time: B 2 (D C(2)Phi (R-0 = 1.617 angstrom, To = 10455 cm(-1). and a), = 1159 cm(-1)), and D(2)Pi (R-0 = 1.632
The overarching aim of this thesis is to study the long term effects of a voluntary speed adaptation system, the Active Accelerator Pedal (AAP), and its effectiveness for different driver types. The papers making up this thesis are based on a study carried out on 284 vehicles and drivers in the Swedish city of Lund from 1999 until 2002. The results showed that the AAP brought a significant reducti
The generalized hole corrected Debye-Huckel theory (Penfold et al J. Stat. Mech. (2005) P06009) is implemented. Predictions of thermodynamic functions and simple structural properties compare favourably with results from closure of the Ornstein-Zernike integral equation in the mean spherical approximation, and with Monte Carlo simulation of the charged hard sphere primitive model. A strictly nonel
