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Striatal neurons forming the indirect pathway (iSPNs) are particularly vulnerable in Huntington's disease (HD). In this study we set out to investigate morphological and physiological alterations of iSPNs in two mouse models of HD with relatively slow disease progression (long CAG repeat R6/2 and zQ175-KI). Both were crossed with a transgenic mouse line expressing eGFP in iSPNs. Using the open-fie
According to the standard story given by reductive versions of the Causal Theory of Action, an action is an intrinsically mindless bodily movement that is appropriately caused by an intention. Those who embrace this story typically take this intention to have a coarse-grained content, specifying the action only down to the level of the agent’s habits and skills. Markos Valaris (2015) argues that,
We outline a conceptual strategy for implementing conservation interventionsin a multiscale, multiactor, and multilevel governance world. Using farmlandas an example, we argue that conservation interventions should be implementedwithin a multiscale framework of guiding ecological principles. Inthis context, findings from multilevel governance research can inform a nuancedunderstanding of the role
The new aminoalcohol phenol 2,4-di-tert-butyl-6-(((2-hydroxy-2-phenylethyl)amino)methyl)phenol (H2L) was prepared by a facile solvent-free synthesis and used as a tridentate ligand for new cis-dioxomolybdenum(vi)(L) complexes. In the presence of a coordinating solvent (DMSO, MeOH, pyridine), the complexes crystallise as monomeric solvent adducts while in the absence of such molecules, a trimer wit
Objectives: Guidelines recommend a 0-hour/1-hour high-sensitivity cardiac troponin T (hs-cTnT) diagnostic strategy in acute chest pain patients. There are, however, little data on the performance of this strategy when combined with clinical risk stratification. We aimed to evaluate the diagnostic accuracy of an accelerated diagnostic protocol (ADP) using the 0-hour/1-hour hs-cTnT strategy together
New nanoarchitectures can be built from polycyclic aromatic hydrocarbons (PAHs) by exploiting the capability of some metal surfaces for inducing cyclodehydrogenation reactions. This bottom-up approach allows the formation of nanostructures with a different dimensionality from the same precursor as a consequence of the diffusion and coupling of the PAHs adsorbed on the surface. In this work we pres
Recently, decreased levels of apolipoprotein M (ApoM) were shown to be associated with higher risk of recurrent venous thromboembolism (VTE) in male patients. However, the role of ApoM in primary VTE is unknown. We aimed in our study to analyze the plasma levels of ApoM in patients with VTE in order to evaluate the diagnostic importance of ApoM in primary VTE. A total of 357 patients with suspecte
Solvent effects on the decomposition of formic acid over a Co(111) surface were studied via density functional theory calculations combined with a continuum implicit solvation model. The solvents used here were water, methanol, and acetone. The adsorption energies of key intermediates, the activation barriers and the rate and equilibrium constants of various elementary reactions in vacuum and in t
Abstract not available
This thesis discusses a number of robot touch perception systems. All these systems are self-organizing and model different aspects of human touch perception. The thesis starts out with introductions to the anatomy and the physiology of the human hand. It proceeds with an overview of the human touch perception from both a neurophysiological and a behavioural perspective. Then related robotic resea
The aim of this work was to develop a pharmacokinetic model for the analysis of the pharmacokinetics of (111)Inlabeled monoclonal antibodies (mAbs) in B-cell lymphoma patients and to evaluate the model's ability to predict a subsequent radioimmunotherapy by (90)Y-labeled mAbs. Data from quantified scintillation camera images and blood samples were used to fit a compartment model. The modeling incl
In a single theoretical framework, real and virtual photon interactions are modeled for gamma-p and gamma-gamma collisions. The description covers aspects from the production of jets to total cross sections, where special emphasis is put on the range of uncertainty in the modeling of a resolved photon component. Our approach extends on a model for photoproduction, where the total cross section is
The objective of this study has been to create an online system for condition monitoring and diagnosis for a combined heat- and power plant in Sweden. This system consists of artificial neural network models, representing each main component of the combined heat- and power plant, accompanied with a graphical user interface. The artificial neural network models are integrated on a power generation
Popular Abstract in Swedish Introduktion till nukleotider Nukleotider är viktiga byggstenar för DNA och RNA. Det finns två typer av nukleotider, puriner och pyrimidiner. Nukleotider kan även fungera som signalmolekyler inom eller mellan celler. Dessutom kan många encelliga mikroorganismer, så som jäst och bakterier, använda dem som kvävekälla, genom att bryta ner dem och utvinna kvävet, som sedan Pyrimidines are important precursors for nucleic acids, and constantly synthesized and degraded in the cell to maintain a balanced supply. Many microoganisms can also extract the nitrogens from the pyrimidine ring, and use them as a nitrogen source when “preferred” sources are absent. Four different pathways, by which pyrimidines can be degraded, are known. I have studied the last discovered, but
The new challenge of the Gas Turbine industry is to develop new technologies for meeting electricity demand growth and reducing harmful emissions. Thus a better understanding of the combustion phenomenon and an improvement in simulation capabilities are needed. Large Eddy Simulation tools brought the hope of meeting these two conditions and enabling the design of safe and clean burners. In the pre
The paper suggests conditions for presence of quadratic Lyapunov functions for nonlinear observer based feedback systems with an 'input nonlinearity' in the feedback path. Provided that the system using state feedback satisfies the Circle Criterion (i.e., when all states can be measured), we show that the extended system with only output feedback control from a (full state) Luenberger-type observe
