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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 195488 hits
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As engineering systems become more and more advanced, the need for collaboration and communication between dierent system areas increases. Systems Modeling Language (SysML) is a graphical modeling language developed to provide a modeling capability independent of the system area. In this thesis, a SysML model will be developed for a reverse osmosis water purication plant. The purpose of the model
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New product development is a complex process for bringing new products to the market. While manufacturing is a very repetitive process, the new product development has to be more flexible as the same product is never developed again. Therefore the theory behind lean manufacturing is not applicable in new product development. The purpose of this study is to propose improvements to Oriflame’s new pr
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Palatal Sound is a model of vocal tract articulation influenced by physiologic and acoustic analysis of the voice. Specifically, the term articulation refers to all movement within the vocal tract that results in open, filter-like sonorities, as well as in turbulent to absolute airflow modification. This model presents a complete mapping of place within the vocal tract that features flexibility ac
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For the last two decades, international investment arbitration has been the most effective and reliable mechanism utilised by investors as a shield under the international protection against excessive states’ intervention. Acknowledging the significance of preserving a safe environment for conducting investments as well as promoting foreign direct investment was the leading element in the process
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In a world where the concept of just-in-time has been lifted outside of the manu-facturing world and onto the market, the increasing demand of luxury wares like cars is accompanied only by tougher industrial conditions and no room for error. Loss of productivity and decrease in efficiency can be devastating to any manufac-turing company in today’s market climate. One of the largest causes of these
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The pentadentate ligand 2-(pyridine-2-yl)-N,N-bis(pyridine-2-ylmethyl)quinoline-8-amine was isolated and characterized. Mononuclear iron(II) complexes of the ligand have been synthesized and characterized. Three iron complexes, [Fe(CH3CN)L1][OTf2], [Fe(OTf)L1] and [Fe(Cl)L1][Cl6Fe2O] (L1 = 2-(pyridine-2-yl)-N,N-bis(pyridine-2-ylmethyl)quinoline-8-amine) (OTf = triflate, trifluoromethane sulfonate)
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Happiness is an affect. Affects are thought to be part of our subjective experiences. In the past, human beings have constructed complex relationships with happiness outside of ourselves. Since sociocultural values laden to happiness established various linkages with objects, happiness seemed to become materialised and accessible, which is expressed, for example, as the UN’s World Happiness Report
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Cycling has been identified as a central element of the solutions to some of the most pressing challenges for today’s cities, such as poor air quality, rising CO2-levels due to emissions from motorised traffic, traffic congestions, and sedentary lifestyles. A high-quality, safe, and widespread network of cycling infrastructure is a key part in the quest to encourage more people to choose the bicyc
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This essay is a study of the Central American migrant caravans that travelled through Mexico from 2018 to 2019 in order to reach the US. It aims to explain how the US influenced Mexico’s handling of the caravans and further explores how the people of the caravan were affected by Mexico’s migration policies. The essay uses Immanuel Wallerstein’s world-systems analysis to explain the unequal relatio
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This thesis describes a method for concluding attributes of a star (including ages, temperatures, chemical element abundances) from its spectra. The method was developed by the 4MOST (4-metre Multi-Object Spectroscopic Telescope) consortium. How the model outputs stellar attributes by receiving spectra is too complicated to be included in one thesis, so only introductions of numerical methods whic
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Patients with systemic lupus erythematosus (SLE) face an approximately 30 % risk of thrombosis post-diagnosis. However, there remains significant knowledge gaps regarding causative mechanisms, and there is a lack of specific antithrombotic guidelines. This systematic review aims to examine the existing literature regarding the mechanisms contributing to thrombosis risk in SLE, focusing on five pre
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Integrative lighting promoting circadian health has recently gained attention due to the increasing awareness of non-visual effects of light and advancements in lighting technology. However, reaching both visual and non-visual circadian targets in buildings may be challenging when considering energy use. Despite growing interest, most studies have focused on health benefits and individual design p
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Morphological traits of animals have evolved to solve ecological requirements, the optimization of locomotion in each environment being one of the most frequent selective forces shaping morphology. Amphisbaenians are strictly fossorial reptiles that have evolved various snout shapes for burrowing head-first underground, yet the evolutionary and ecological origins of these different morphologies ar
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BACKGROUND: The Apnea-Hypopnea Index (AHI), the standard measure of obstructive sleep apnea (OSA), has limitations in reflecting disease severity.RESEARCH QUESTION: Is high hypoxic burden (HB) more strongly associated with major cardiovascular and cerebrovascular adverse events (MACCEs) than AHI≥ 30/h?STUDY DESIGN AND METHODS: This secondary analysis of the RICCADSA observational cohort included 3
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Improving spark-ignition engines in terms of efficiency and compatibility with renewable fuels is essential for ensuring energy security, cost-effectiveness, and sustainability. However, electrode wear of spark plugs, especially under conditions involving novel fuels and lean mixtures, becomes a significant technical challenge. Therefore, a deeper understanding of the interactions between spark di
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The concept of the rule of law has been a central issue in China for the past two decades, gaining even greater prominence under Xi Jinping’s leadership. This article examines the development of the rule of law in China, drawing on insights from local Chinese scholarship as a vital source for understanding the situation. By analyzing the most cited research articles in the China National Knowledge
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The catalytic activity of the binuclear glyoxalase II (GlxII) enzyme is closely linked to the type and charge of metal ions in its active site. Using hybrid quantum mechanics/molecular mechanics (QM/MM) calculations, we investigated the reaction mechanism of human GlxII, which features two Zn(ii) ions in its active site. By systematically replacing these Zn(ii) ions with Fe(ii), Fe(iii), or Co(ii)
