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Your search for "Identification of severity related mutation hotspots in SARS-CoV-2 using a density-based clustering approach" yielded 194604 hits

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Portugal's real income per head grew by a factor of eight during the second half of the twentieth century, a period of fast convergence towards Western European standards of living. We use a new sample of about 2,000 children to document trends in the prevalence of stunting and wasting in the city of Lisbon between 1945 and 1994. We find that stunting and wasting fell quickly in the 1950s and 1960

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Machado-Joseph disease (MJD/SCA3) is the most frequent dominant ataxia worldwide. It is caused by a (CAG)n expansion. MJD has two major ancestral backgrounds: the Machado lineage, found mainly in Portuguese families; and the Joseph lineage, present in all five continents, probably originating in Asia. MJD has been described in a few African and African-American families, but here we report the fir

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Background: The objective of this study was to explore the potential of Airspace Dimension Assessment (AiDA) to rapidly determine the type and severity of airway obstruction, detect emphysema in individuals with chronic airflow limitation (CAL), and distinguish it from non-emphysematous obstruction, asthma, and absence of respiratory disease with normal spirometry. Methods: Among the 744 participa

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AbstractBackground:Multidrug-resistant Acinetobacter baumannii remains as a global concern with its ability to adhere, disperse and sustain on areas involving suboptimal infection control measures, especially war zones. We aimed to evaluate the molecular epidemiology and virulence factors of A. baumannii isolates from conflict zone in Ukraine.Methods:In 2022, 46 A. baumannii wound isolates were re

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Background Early recognition of emerging heart failure prior to diagnosis could offer an opportunity for prevention-focused care, but it remains unclear whether healthcare seeking patterns before diagnosis indicate an earlier window for intervention. The objective was to determine if changes in utilization appeared during the 12-week pre-diagnosis period preceding a first diagnosis of heart failur

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The thesis is based on a field study carried out in India, Nepal and Tibet during the period of June?August 2005. It examines gender structures in Tibetan society and seeks to explain the background and reasons to existing social and political structures. The object is to call attention to general conclusions regarding equality gathered in the field by focusing on social efficiency rather than

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Over the centuries the Mayan indigenous population has been excluded from power politics in Guatemala. During the last decades much attention by scholars has been placed on the Mayan movement, as a new and unconventional political actor. In this study I examine why and how this actor has emerged, with specific consideration on the shift from class to culture. By drawing on theories of civil societ

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Background: Access to contraception can be a transformational intervention towards advancement of education, health, and freedom of choice. Countries have committed to improving access to contraception enshrined in the sustainable development goals (SDGs), indicator 3.7.1. Our study seeks to investigate the level of inequality in current use of modern contraception and unmet need for contraception

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OBJECTIVES: The efficacy of long-term opioid therapy (LTOT) in treating patients with chronic non-cancer pain (CnCP) is questionable, and the potential risks of adverse effects are well established. The aims were as follows: (1) compare characteristics in patients exposed to LTOT vs non-exposed. (2) Regarding opioid-exposed patients, describe characteristics of patients with risk factors for opioi

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Self-injury is associated with significant psychological distress and functional impairments, including difficulties with self-care. However, little is known about how individuals engaging in self-injury perceive and manage self-care in their daily lives. This study aimed to explore the lived experiences of self-care among individuals receiving psychiatric treatment for self-injury and to identify

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This article further theorises and develops the notion of a threat of abandonment while trying to elucidate the applicability and usefulness of this concept in the case of Ukraine in its fight against Russia since 2014. If Ukraine perceives the European Union (EU) as weakened by multiple crises, it may translate this image into a scenario of less attention to Ukraine and its problems, and – ultima

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Objectives: The only treatment with curative potential for distal cholangiocarcinoma (dCCA) is radical surgery which can be complemented with adjuvant chemotherapy. The aim of the present study was to perform an independent external validation of a prognostic model for 3-year overall survival based on routine clinicopathological variables for patients treated with pancreatoduodenectomy for dCCA. M

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Knowledge of human fetal blood development and how it differs from adult blood is highly relevant to our understanding of congenital blood and immune disorders and childhood leukemia, of which the latter can originate in utero. Blood formation occurs in waves that overlap in time and space, adding to heterogeneity, which necessitates single-cell approaches. Here, a combined single-cell immunopheno

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'Daniel Hjorth and Chris Steyaert set out to advance the study of entrepreneurship by refocusing the lens of discovery from economics, management and marketing to other paradigmatic stances in social sciences and humanities like anthropology and literary studies. The result is a provocative collection of chapters that inspire the reader to consider and explore new ideas and research practice that

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Background: Elderly people tend to be sicker than young people. They also take more medications, increasing the risk of adverse drug reactions (ADRs), which are one of the leading causes of morbidity and mortality in this age group. Knowledge of cutaneous ADRs from medicine use in the elderly population is limited.Objective: The aim of this study was to investigate demographic data, causative drug

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Purpose Multiple phenotypes characterized by different disease mechanisms have been hypothesized to explain the large variability in the knee osteoarthritis (KOA) population. The purpose of this study was: to estimate and compare the medial and lateral knee compression forces (CF) during gait of three subgroups of KOA subjects characterized by different alignment and cartilage disruption patterns.

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Objective To elucidate experiences and coping strategies among adults in the surveillance of indeterminate pulmonary nodules detected with CT in the population-based Swedish CardioPulmonary bioImage Study (SCAPIS).Design A qualitative study of conventional content analysis.Settings The study was conducted at a university hospital in a southern region of Sweden. The SCAPIS setting is similar to the

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Background Use of artificial intelligence (AI), or machine learning, to assess dermoscopic images of skin lesions to detect melanoma has, in several retrospective studies, shown high levels of diagnostic accuracy on par with - or even outperforming - experienced dermatologists. However, the enthusiasm around these algorithms has not yet been matched by prospective clinical trials performed in auth