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Hereditary spastic paraplegias (HSP) are the second most common type of motor neuron disease recognized worldwide. We investigated a total of 25 consanguineous families from Sudan. We used next-generation sequencing to screen 74 HSP-related genes in 23 families. Linkage analysis and candidate gene sequencing was performed in two other families. We established a genetic diagnosis in six families wi
Two new Geissleria species from Siberian mountain lakes Baikal and Frolikha are described based on molecular and morphological data. The two new species are Geissleria baicalosimilis Kulikovskiy, Gusev, Andreeva & Annenkova sp. nov. and G. frolikhiensis Kulikovskiy, Gusev, Andreeva & Annenkova sp. nov. According to partial 18S rDNA and rbcL gene fragment analyses, Geissleria does not belon
Background: Postnatal sense of security, for parents, the first week after childbirth is important for their own and their baby’s wellbeing. Variables influencing the mother’s, and particularly the father’s, sense of security during the first postnatal week are not well known. No instrument measuring dimensions which can be influenced and supported by the postnatal health care team has been found
The genus Capoeta in Iran is highly diversified with 14 species and is one of the most important freshwater fauna components of the country. Central Iran is a region with high number of endemism in other freshwater fish species, though the present species was recognized as C. aculeata (Valenciennes, 1844), widely distributed within Kavir and Namak basins. However previous phylogenetic and phylogeo
Waste heat recovery systems for power generation are gaining interest among the marine transport sector as a solution to accomplish the upcoming more restrictive regulations on emissions, and to reduce the total fuel consumption. In this paper we evaluate how a waste heat recovery system based on a regenerative organic Rankine cycle (rORC) could improve the performance of a passenger vessel. The c
A soft x- ray laser from Ni- like Mo, pumped in grazing incidence ( GRIP), is analyzed with regard to high repetition rate operation. Reliable lasing is obtained, but with significant energy fluctuations attributed mainly to beam pointing jitter from the pump laser. Two modes of operation are compared: continuously moving target and stationary target. With a moving target the soft X- ray output is
Background: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33 degrees C or 36 degrees C temperature control for 24 hours after cardiac arrest and the effects on survival and neurological outcome assessed. This protocol describes a sub-study of the TTM-trial i
Effective disaster risk management is a requisite for sustainable development and it is paramount to include a wide range of stakeholders to manage risk in this context. Recent research indicates the significance of making ideas of what is valuable and important to protect explicit in any disaster risk management initiative that involves several stake- holders. The purpose of this article is thus
We suggest a physical picture of the catalytic act combining together the energy transfer and the synchronisation of the best electron density in the reactant and active site as a consecutive sequence of events. Activity and selectivity at molecular level are defined. Geometry requirements seem to be linked to energy and time requirements. Our proposal for developing new catalysts at the molecular
PURPOSE: To describe and evaluate the new rapid SITA Fast computerized perimetric threshold strategy.METHOD: Computer simulations of visual fields were used to develop a new rapid threshold strategy, SITA Fast. In a clinical evaluation 30 patients were examined twice with each of the Full Threshold, Fastpac and SITA Fast strategies.RESULTS: SITA Fast had significantly shorter test time using on av
Type specimens of Sympycnus pulicarius, S. annulipes, S. cinerellus and S. desoutteri were examined to clear up a long-lasting taxonomic confusion. Our study revealed that they represent, together with S. pygmaeus and S. annulipes var. brunnitibialis, a single species, with S. pulicarius as the senior subjective synonym, which is redescribed in this paper. Lectotypes were designated for Dolichopus
Introduction: Timely diagnosis and treatment are essential for improving outcomes and quality of life in patients with transthyretin (ATTR) amyloidosis. Early multisystem manifestations are often unrecognized, leading to diagnostic delays and misdiagnosis. Large-scale, multicountry, observational studies are needed to better characterize the real-world trajectory of these patients. Methods: OverTT
An unmanned ship can be designed without considering humancomfort, and can thus be constructed lighter, smaller and less expensive.It can carry out missions in rough terrain or be in areaswhere it would be dangerous for a human to operate. By not havingto support a crew, lengthy missions can be accepted, enabling, e.g.reconnaissance missions, or reducing emissions by lowering thespeed.Breakthrough
Research in wind power generation technology is a topic of high relevance in the context of renewable energy systems. This project aims to develop and implement an automatic operation and control system for an experimental vertical axis wind turbine (VAWT) located at Lunds Tekniska Högskola, in Sweden. Supervisory control and data acquisition systems (SCADA) are increasingly considered indispensab
The Brazilian National Synchrotron Light Laboratory, LNLS, operates a 1.37 GeV electron storage ring with a 120 MeV injector Linac. Commissioning of the storage ring at low energy started on May 1996 and now, an year later, we can store 120 mA at 120 MeV and ramp more than 75 mA to 1.37 GeV. A summary of the latest commissioning results and a description of the present operational performance of t
Numerous lineages of avian malaria parasites of the genus Plasmodium have been deposited in GenBank. However, only seven morphospecies have been linked to these lineages. This study linked two molecular sequences with morphospecies of malaria parasites. Two species of Plasmodium (mitochondrial cytochrome b gene lineages P-GRW2 and P-GRW4) were isolated from naturally infected adult great reed warb
Nemacheilid fishes in the genus Turcinoemacheilus are physically small members of the ichthyofauna communities of high-altitude and mountainous freshwater ecosystems. They are all distributed in Western Asia apart from a single species, described in the Himalayas. They are usually very similar in appearance, which complicates their proper identification and/or description. This is why it is import
Transfer of collagen type H (CH)-specific monoclonal antibodies induces an acute form of arthritis (collagen type H antibody-induced arthritis, CAIA) in nave mice. Arthritis was induced using a pair of monoclonal antibodies M2139 and CIIC1, binding to J1 and C1(I) epitopes of CH, respectively. Thereafter, lipopolysaccharide injection was used to increase the incidence and severity of the disease.
