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OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort.RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin (IAA) or GAD (GADA) as the first-appearing autoantibody were assessed in a 10-year follow-up of 7,867 children. Stool vi

Background: Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990–2021. Methods: We estimated incidence, prevalence, death, and disability-adjusted life-year (DALY) counts and age-standard

In two late Mesolithic cemeteries, dated to about 5000 bce, at Skateholm, Scania in Sweden, some graves were found that contained clothing decorations, mainly in the form of tooth beads but also other animal parts that were used as embellishments. These are perforated front teeth, mostly from red deer but also wild boar and on rare occasions from elk and aurochs. The tooth beads in female graves w

Education reduces the intergenerational transfer of poverty and boosts growth according to the Social Investment (SI) approach (Morel, Palier, and Palme 2011). However, educational systems differ in their capacity to promote equality and produce the skills needed in today‘s knowledge economies. Despite extensive scholarship on how education policies vary in terms of their social and economic effec

The longitudinal motion and the intramural shear strain of the arterial wall increase dramatically in response to blood pressure, thereby impacting the vascular wall microenvironment. Exposure to a sedentary lifestyle has been identified as an independent risk factor for cardiovascular disease, but it has been shown that intermittent physical activity embedded into everyday life is enough to impro

The Restricted Syndrome Decoding Problem (RSDP) is a variant of the well-known syndrome decoding problem. It has been recently turned into a post-quantum signature scheme named CROSS by Baldi et al.. It is a scheme highlighted for being computationally friendly and providing a compact signature and public key size. This paper investigates an Oracle-based definition of the RSDP that has already pro

The modern food industry faces the challenge of catering to diverse consumer preferences while maintaining efficiency and profitability. Rapid shifts in consumer trends, emerging technologies, and evolving regulations make it difficult for companies to keep pace, often resulting in inefficiencies and lost opportunities. The vast amount of data generated across production, supply chains, and marke

This chapter departs from two research projects to present the learnings, methodological challenges, and recommendations when involving users in participatory approaches of design research in home care. In the first project, older participants collected data through solicited diaries and photo elicitation, reflecting about their use of multiple medications and difficulties experienced with medicat

This paper explores acceleration of the finite element-boundary integral hybrid method using the adaptive cross approximation. Our code implementing the hybrid method in Python based on open source packages is briefly presented. A simple one-level version of the adaptive cross approximation is described and it is used to accelerate the boundary integral matrices. We present results for scattering

In this position paper we argue for a radical departure from today's approach to software engineering, centered on target-specific tools and general processes such as modeling and agile practices. The old principle of right tool for each problem shall be applied to software engineering as well: to address ever higher complexity, we need to raise dramatically the level of abstraction; as general so

The strong negative relationship between geographical distance and trade is not well understood. I use the liberalization of the Soviet airspace to estimate the causal impact of business travel cost on trade. The liberalization radically reduced travel time between Europe and East Asia and was followed by a significant increase in trade. I find that the cost of business travel can account for a la

The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferation, differentiation, and activation. Metabolic changes imposed by environmental stress and inflammation on immune cells and tissue microenvironment are thus chi

Following the successful operation of the Multipole Injection Kicker (MIK) in the MAX IV 3 GeV storage ring, we plan to introduce a similar device in the MAX IV 1.5 GeV ring. In order to assess the effectiveness of such device and to define its working parameters, we performed a series of studies aimed at understanding the beam dynamics related to the injection process. In this paper we describe t

In order to keep up with the constant demand for higher data rates, the fifth generation of mobile communication (5G) introduced the use of mm-wave carrier frequencies from 24 to 71 GHz. Plenty of new frequency spectrum then became available, which has allowed for channel bandwidths of several hundreds of MHz. 6G is projected to continue this trend with even higher carrier frequencies and wider ba

Recent findings support the hypothesis that inhibition of SMYD3 methyltransferase may be a therapeutic avenue for some of the deadliest cancer types. Herein, active site-selective covalent SMYD3 inhibitors were designed by introducing an appropriate reactive cysteine trap into reversible first-generation SMYD3 inhibitors. The 4-aminopiperidine derivative EM127 (11C) bearing a 2-chloroethanoyl grou

Objectives.: To assess the comparability of the Tandem-R and IMx serumprostate-specific antigen (PSA) assays across levels of the ratio of free-to-total serum PSA found in a community-based population of healthy men. Methods.: Banked serum samples from the baseline component of the Olmsted CountyStudy of Urinary Symptoms and Health Status Among Men were thawed and analyzed using the Tandem-R and I