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The effects on driving performance of using a hands-free, mobile telephone were investigated in a pursuit-tracking task that simulated driving. Twenty subjects in two age groups, 19-26 years (median = 21 years) and 40-51 years (median 45·5 years), participated, with five males and five females in each group. The primary task was driving safely. The subjects drove for 20 min in each of three second
Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in
Objective: Schizophrenia is associated with premature mortality, but the specific causes and pathways are unclear. The authors used outpatient and inpatient data for a national population to examine the association between schizophrenia and mortality and comorbidities. Method: This was a national cohort study of 6,097,834 Swedish adults, including 8,277 with schizophrenia, followed for 7 years (20
Background Early access to diagnosis is crucial for effective management of any disease including tuberculosis (TB). We investigated the barriers and opportunities to maximise uptake and utilisation of molecular diagnostics in routine healthcare settings. Methods Using the implementation of WHO approved TB diagnostics, Xpert Mycobacterium tuberculosis/rifampicin (MTB/RIF) and Line Probe Assay (LPA
OBJECTIVE:: To assess the prognostic value of continuous amplitude-integrated electroencephalogram in comatose survivors after cardiac arrest and treated with hypothermia. DESIGN:: Prospective observational study. SETTING:: General intensive care unit at a university hospital. PATIENTS:: Comatose patients after cardiac arrest and treated with hypothermia. INTERVENTIONS:: Patients were sedated and
We report on the influence of pH and monovalent/divalent cations on the catalytic current response, internal electron transfer (IET), and structure of fructose dehydrogenase (FDH) by using amperometry, spectrophotometry, and circular dichroism (CD). Amperometric measurements were performed on graphite electrodes, onto which FDH was adsorbed and the effect on the response current to fructose was in
Hip geometry is an important predictor of fracture. We performed a meta-analysis of GWAS studies in adults to identify genetic variants that are associated with proximal femur geometry phenotypes. We analyzed four phenotypes: (i) femoral neck length; (ii) neck-shaft angle; (iii) femoral neck width, and (iv) femoral neck section modulus, est
Cerebral accumulation of amyloid-β is thought to be the starting mechanism in Alzheimer's disease. Amyloid-β can be detected by analysis of cerebrospinal fluid amyloid-β42 or amyloid positron emission tomography, but it is unknown if any of the methods can identify an abnormal amyloid accumulation prior to the other. Our aim was to determine whether cerebrospinal fluid amyloid-β42 change before am
Purpose: To describe the use of assistive devices and postural asymmetries in lying, sitting and standing positions in adults with cerebral palsy, and to analyze postural asymmetries and any associations with their ability to maintain or change position and time in these positions. Methods: A cross-sectional study based on data from the Swedish Cerebral Palsy follow-up program of 1,547 adults aged
Introduction: This study evaluated lipid identification using mass spectrometry. Background: Three main modes of acquisition are used in mass spectrometry of lipids; data-independent acquisition (DIA), data-dependent acquisition (DDA) and targeted acquisition. DIA is the most including one, yielding a complete but complex data set, while targeted is the least including one, basing acquisition on
Med avstamp i den mänskliga rättigheten att söka asyl och den väletablerade rätten till internationellt skydd för den som uppfyller flyktingdefinitionen, belyser uppsatsen exklusionsbestämmelserna, undantaget som kan utesluta en person från flyktingskydd. De humanitära skyddsåtgärder som Flyktingkonventionen erbjuder förverkas nämligen om det finns synnerligen anledning att anta att den asylsökandThis thesis starts off in the human right to seek asylum and the recognized right to international protection for refugees. It examines the exclusion clauses, the exception that can exclude asylum claimants from refugee protection. The protective measures guaranteed by the Refugee Convention are forfeited if there are serious reasons for considering that the claimant has committed crime against pe
In a population-based study on cobalamin status and incident fractures in elderly men (n = 790) with an average follow-up of 5.9 years, we found that low levels of metabolically active and total cobalamins predict incident fractures, independently of body mass index (BMI), bone mineral density (BMD), plasma total homocysteine (tHcy), and cystatin C. Cobalamin deficiency in elderlies may affect bon
A powerful cartel forces customers to pay significantly more for products and eliminates competition since its participants do not need to improve their productivity or the quality of their products. Cartels have historically exercised great influence over the international economy. During the inter-war period cartels were so powerful that economists have estimated that international cartels contr
Background: Left ventricular (LV) dysfunction is well documented in the critically ill. We assessed 1-year mortality in relation to cardiac biomarkers and LV function parameters by echocardiography in patients with shock. Methods: A prospective, observational, cohort study of 49 patients. B-natriuretic peptide (BNP), high-sensitive troponin T (hsTNT) and transthoracic echocardiography (TTE) were a
Introduction. Palliative cancer care in acute hospitals is scarcely studied. We therefore described and compared symptoms, care needs and types of cancer sites in 2002 compared to 2007 and analysed the relationships between these factors. Methods. The study was population-based with a cross-sectional design and was carried out in medical, surgical and oncology wards in two acute care hospitals wit
In public safety oversight authorities are traditionally assumed responsible of safeguarding operation and promoting safety by defining prescriptions and observing that they are complied with. Regulated entities on their side are assumed responsibility for complying. While this compliance-based approach has contributed to current levels of safety, it is increasingly debated that it has limitatio
2005 släppte Förenta Nationernas folkrättskommission rapporten "Fragmentation of International Law: Difficulties arising from the diversification and expansion of International Law". Även om fragmenteringen av folkrätten hade varit ett diskussionsämne långt före 2005 fick rapporten verkligen debatten ta fart och fragmentering att bli en av de mest omdebatterade frågorna under senare år bIn 2005 the United Nations International Law Commission released the report Fragmentation of International Law: Difficulties arising from the diversification and expansion of International Law. Although fragmentation of international law had been a topic of discussion long before 2005 the report really made the debate take off, becoming one of the most debated issues in recent years among internat
Utsagor från vittnen är ett väsentligt inslag i en effektiv rättskipning. Hot och våld mot vittnen utgör därför ett stort hinder i det brottsbekämpande ar-betet. Om det allmänna inte kan erbjuda vittnen ett tillräckligt skydd vid så-dana angrepp, finns det risk att vittnen väljer att inte samarbeta med polisen, vilket i sin tur kan få till följd att grova brott förblir ouppklarade. I denna studie Statements by witnesses are an essential element of the efficient administra-tion of justice. The occurrence of serious forms of threats and violence to-wards witnesses and their relatives therefore constitutes a major impediment to the work in combating crime. If the public cannot offer witnesses suffi-cient protection from attacks, there is a risk that they will choose not to co-operate with the
Over recent decades, use of insecticides to protect plants from pests and harmful insects have increased manyfold. Neonicotinoid insecticides, such as Imidacloprid (IMI) acts as partial agonists on nicotinic acetylcholine receptors which are widely present in both the central and peripheral nervous system of insects. Pollinators like Eristalis tenax are frequently exposed to these pesticides but h
Allogeneic HSCT represents the only potentially curative treatment for very high risk (VHR) ALL. Two consecutive international prospective studies, ALL-SCT-(I)BFM 2003 and 2007 were conducted in 1150 pediatric patients. 569 presented with VHR disease leading to any kind of HSCT. All patients >2 year old were transplanted after TBI-based MAC. The median follow-up was 5 years. 463 patients were tran
