BACKGROUND: Calpain-10 was the first gene to be identified influencing the risk of type 2 diabetes (T2D) by positioning cloning. Studies in beta-cell lines and rodent islets suggest that calpain-10 may act as a regulator of insulin secretion. However, its role in human pancreatic islets remains unclear. The aim of this study was to examine if calpain-10 expression is altered in islets from patient

The concentration of circulating insulin oscillates with periods of 3-6 min due to pulsatile release of the hormone from the pancreas. Pulsatile insulin secretion from the individual * cell is driven by slow cycles of Ca2+ elevation due to periodic depolarisation. The Ca2+ oscillations of individual * cells in the islets of Langerhans are entrained into a common rhythm by gap junctional coupling a

Despite the key role of primary and secondary lymphoid organ stroma in immunity, our understanding of the heterogeneity and ontogeny of these cells remains limited. Here, we identify a functionally distinct subset of BP3(-)PDPN(+)PDGFRβ(+)/α(+)CD34(+) stromal adventitial cells in both lymph nodes (LNs) and thymus that is located within the vascular niche surrounding PDPN(-)PDGFRβ(+)/α(-)Esam-1(+)I

Popular Abstract in Swedish En indikator-jon för en kvantdator Ända sedan transistorn uppfanns 1948 har datorer blivit allt mer kraftfulla. Trots den enorma utveckling som skett finns det fortfarande problem som är för svåra för en dator att lösa. Ett exempel är simulering av stora molekyler, t.ex. proteiner, vilket skulle vara användbart inom medicin och biologi, bland annat för att förutsäga hRare-earth ions doped into a transparent crystal can have optically excited states with coherence times of milliseconds and hyperfine levels with coherence times of hours when cooled down to liquid helium temperatures. This makes them attractive for developing quantum computing hardware. A quantum transistor can be implemented in a rare-earth-ion-doped crystal by utilizing a dipole blockade effe

PURPOSE: To prospectively evaluate the usefulness of magnetic resonance (MR) imaging for estimating pulmonary blood volume (PBV) and the variation in PBV throughout the cardiac cycle in experimental heart failure. MATERIALS AND METHODS: The animal care committee approved this prospective study. Seven pigs were studied before and after myocardial infarction. PBV measurement was validated in a phant

OBJECTIVE: To investigate if placental Doppler velocimetry can predict the recurrence of a small-for-gestational age (SGA) fetus in subsequent pregnancies. DESIGN: Retrospective study. SETTING: City cohort over 15 years attending a university hospital. METHODS: A total of 196 pregnancies suspected of a SGA fetus (

The isomeric diazadithiapentacenes (3) and (4) were obtained in reactions of 2-chloro-3-bromoquinoline (5) with selected sulfur reagents in various conditions. The 1,4-dithiin ring opening in diazadithiapentacene (3) led to 2,3’-diquinolinyl sulfide or (via the Smiles rearrangement stage of the S→S type) to 3,3’-diquinolinyl sulfide or to diazadithiapentacene (4) depending on reaction conditions.

BACKGROUND: Job strain and the Arg389Gly polymorphism in the adrenergic beta1-receptor gene have been linked to hypertension. We aimed to study whether there is an interaction between the Arg389Gly polymorphism and job strain and its components (job demand and decision latitude) in relation to blood pressure. METHODS: From the Malmö Diet and Cancer population cohort, 6095 individuals were randomly

The existence of a uniform phase at the alveolar surface is demonstrated by polarizing microscopy and cryogenic transmission electron microscopy (cryo-TEM). Rabbit lungs were opened and the alveolar surface film was directly deposited on optical microscope coverslips and on electron microscope grids. In the polarizing microscope, the alveolar surface material deposited exhibits a uniform birefring

Pathogenicity of many microbes relies on their capacity to resist innate immunity, and to survive and persist in an immunocompetent human host microbes have developed highly efficient and sophisticated complement evasion strategies. Here we show that different human pathogens including Gram-negative and Gram-positive bacteria, as well as the fungal pathogen Candida albicans, acquire the human term

Popular Abstract in Swedish Denna avhandling ger ett bidrag till teorin om strategisäkra kollektiva beslut. I denna teori undersöks under vilka förutsättningar det är möjligt att konstruera omröstningsprocedurer (hädanefter kallade för kollektiva valfunktioner) som är strategisäkra i den bemärkelsen att ingen väljare kan ändra utfallet av en omröstning till sin fördel genom att inte rösta enligt sThis thesis makes a contribution to strategy-proof social choice theory, in which one investigates the conditions under which it is possible to construct social choice functions (i.e., voting procedures) that can never be manipulated in the sense that some voter, by misrepresentation of his true preferences, can change the outcome of a voting and obtain an alternative he prefers to the one that ho

PURPOSE: To prospectively register and report the hand function and occupational performance of patients with proximal interphalangeal joint-pyrocarbon arthroplasty, using both objective tests and subjective outcome instruments. METHODS: From 2004 to 2008, 53 joints in 43 patients were reconstructed with a proximal interphalangeal joint-pyrocarbon prosthesis. The patients underwent a rehabilitatio

This paper presents a framework for assessing alignment between corporate strategy, procurement strategy and purchasing tools. The framework is built on generation of rents as its common denominator for assessing alignment between the levels. Three types of rents are identified: monopoly rents; Ricardian rents and entrepreneurial rents. The framework is then used for assessing the strategic origin