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Incubation of rat adipocytes with wortmannin, a potent and selective phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor, completely blocked the antilipolytic action of insulin (IC50 = 100 nM), the insulin-induced activation and phosphorylation of cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) as well as the activation of the insulin-stimulated cGI-PDE kinase (IC50 = 10-30 nM). No direct effect
The interference between extrinsic and intrinsic losses in x-ray absorption fine structure (XAFS) is treated within a Green's-function formalism, without explicit reference to final states. The approach makes use of a quasiboson representation of excitations and perturbation theory in the interaction potential between electrons and quasibosons. These losses lead to an asymmetric broadening of the
Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and 10% of the cytogenetically abnormal cases, respectively. However, despite the high frequency of +8, much remains to be elucidated as regards its epidemiology, etiology, clinical impact, association with other chromosomal abno
På begravningsgudstjänsten möts två yrkesgrupper: prästen och begravningsentreprenören. Undersökningar visar att detta möte oftast präglas av ett samarbete där man upplever att man kompletterar varandras arbetsuppgifter och ansvarsområden. Det finns emellertid få strategier och reflektioner bakom detta samarbete, vilket blir tydligt när en konfliktsituation uppstår. I artikeln betonas behovet av a
The tire is a significant part for control of a vehicle. For a well-working brake system the contact properties between the tire and the ground is the limiting factor for a safe braking. To get optimal performance it is important that the system can utilize all friction resources. The brush tire model was a popular method in the 1960's and 1970's before the empirical approaches became dominating.
The various granule subtypes of the human neutrophil differ in propensity for exocytosis. As a rule, granules formed at late stages of myelopoiesis have a higher secretory potential than granules formed in more immature myeloid cells. Neutrophils contain four closely related alpha-defensins, which are stored in a subset of azurophil granules. These defensin-rich azurophil granules (DRG) are formed
Aims - To describe and evaluate the efficacy and safety of intra-arterial fibrinolysis and the clinical outcome in SAH patients with thromboembolic complications during endovascular coiling of a ruptured aneurysm. (Paper I) - To describe the use and feasibility of magnetic resonance imaging (MRI), especially diffusion and perfusion imaging, in three patients treated endovascularly for various ce
This study presents a non-computerized calculation procedure for steady state two-dimensional conductive heat losses through thermal bridges. The heat flow is divided into distinct flow paths based on physical considerations. A resistance is derived analytically for each flow path. These resistances are combined into a net work. The network simulates the construction. Calculating the total resista
What is the relative contribution of genetic and various environmental factors to variation in the ability to mount an immune response? We measured antibody responsiveness to diphtheria-tetanus vaccine during the winter in free-ranging blue tits with a known nestling history to investigate (1) if nutritional status during the nestling stage has persistent effects on an individual's immune defence
Using in situ hybridization, hormone-sensitive lipase was found to be expressed in a stage-dependent manner in Sertoli cells of rat testis. No expression was found in Leydig cells but expression in spermatids could not be excluded. These results suggest a role for hormone-sensitive lipase in the metabolism of lipid droplets in Sertoli cells, in contrast to its previously proposed function in stero
Centrums roll och funktion har förändrats över tiden under perioder av urbanisering, suburbanisering, desurbanisering och reurbanisering. Transportmedelsutvecklingen och olika stadsplaneringstraditioner har påverkat såväl stadsstrukturen som centrums uppbyggnad. Det övergripande syftet med boken är att belysa hur olika bebyggelse- och trafikmässiga faktorer samverkar och formar centrum och centrum
Abstract in Undetermined Fallstudier och användartester; Rörelsehinder; Etik - juridik - ekonomi - tillgänglighet; Synskador och blindhet; Äldre personer; Vardagsteknik
Proteins fold on a mu s-ms time scale. However, the number of possible conformations of the polypeptide backbone is so large that random sampling would not allow the protein to fold within the lifetime of the universe, the Levinthal paradox. We show here that a protein chain can fold efficiently with high fidelity if on average native contacts survive longer than non-native ones, that is, if the d
Popular Abstract in Swedish Inom hälso- och sjukvården betonas att vården ska ges utifrån ett patientorienterat sätt. Om sjuksköterskor skall kunna ge patienten god omvårdnad, måste de själva ha en god arbetssituation. Det blir allt vanligare att sjuksköterskor i arbetet utsätts för en mängd negativa psykiska påfrestningar, såsom hot och våld, som kan leda till stress. Stress kan också relateras tThe purpose of group supervision in nursing care is to understand nurses’ experiences from real care settings and to structure these in a professional and personal context. An interventional and longitudinal method of research was chosen in this study of group supervision in nursing care. The overall aim of the present study was to examine and investigate how psychiatric nurses’ professional compe
In this work we discuss different factors governing coil-globule coexistence in the compaction process of DNA. We initially analyse the role played by fluctuations in the degree of binding of an external compacting agent in the conformational behavior of the chain backbone. The analysis relies both on Monte Carlo simulation results and simple statistical approaches. Compacting agents of various bi
Background: Recent studies revealed that many mammalian protein- coding genes also transcribe their complementary strands. This phenomenon raises questions regarding the validity of data obtained from double-stranded cDNA microarrays since hybridization to both strands may occur. Here, we wanted to analyze experimentally the incidence of antisense transcription in human cells and to estimate their
We predict that in a narrow gap III-V semiconductor quantum well or quantum wire, an observable electron spin current can be generated with a time-dependent gate to modify the Rashba spin-orbit coupling constant. Methods to rectify the so generated ac current are discussed. An all-electric method of spin-current detection is suggested, which measures the voltage on the gate in the vicinity of a tw
