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The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells. The first seven fully characterized organoid lines recapitulate the molecular di
A measurement of b-hadron pair production is presented, based on a data set corresponding to an integrated luminosity of 11.4 fb−1 of proton-proton collisions recorded at s=8 TeV with the ATLAS detector at the LHC. Events are selected in which a b-hadron is reconstructed in a decay channel containing J/ψ → μμ, and a second b-hadron is reconstructed in a decay channel containing a muon. Results are
This paper highlights and discusses the concept of the jubilee in Antiquity through a series of case studies. The ancient jubilee is defined as a temporally based, and often recurring, communal celebration, which encompasses longer time spans, from ten to a thousand years. The examples elaborated on by the present authors are: the Jewish Yovel, the Egyptian Heb-Sed and the Roman decennalia (Leande
In an effort to bioengineer elastomeric particles (EPs), with negative acoustic contrast factor, to capture cells, we have successfully functionalized EPs with anti-human CD45 antibodies that enable capturing of WBCs from human RBC lysed blood samples. We demonstrate that the negative selection of WBCs with EPs and acoustophoresis can be employed to reduce WBC contamination while enriching label-f
Cancer cells display acoustic properties enabling acoustophoretic separation from white blood cells (WBCs) with 2–3 log suppression of the WBC background. However, a subset of WBCs has overlapping acoustic properties with cancer cells, which is why label-free acoustophoretic cancer cell isolation needs additional purification prior to analysis. This paper reports for the first time a proof of conc
A generic robot library written in the Julia programming language is presented. A bridging framework, also presented, exposes the ABB externally guided motion research interface (EGMRI) low-level robot motion correction interface to the Julia language and other entities, such as Python and ROS. A usage example on Julia contact force estimation on an ABB YuMi robot concludes the document.
Red blood cells (RBC) and platelets constitute the non-immune branch of the hematopoietic system and are responsible for the vital functions of transporting oxygen to the tissues and clotting blood vessel injuries, respectively. These cells are produced during embryonic development and throughout life through a process called hematopoiesis which is tightly regulated by extrinsic and intrinsic fact
This paper describes a method to accurately determine the electromagnetic material properties of thin dielectric sheets. For non-magnetic materials, free space transmission measurements relative to an empty setup are sufficient to determine the complex permittivity of the sheet material. Measurements have been performed on a thin resistive sheet and a transformation procedure has been applied wher
This article claims that Svetlana Aleksievich’s Voices from Utopia should be read as testimony. Although based on eyewitnesses interviewed by Aleksievich, the voices represented in the five books are interpreted as the creation of an implied author. In contrast to a theoretical standpoint defining fact in a dichotomous relation to fiction, this study identifies the historical value of Aleksievich’This article claims that Svetlana Aleksievich’s Voices from Utopia should be read as testimony. Although based on eyewitnesses interviewed by Aleksievich, the voices represented in the five books are interpreted as the creation of an implied author. In contrast to a theoretical standpoint defining fact in a dichotomous relation to fiction, this study identifies the historical value of Aleksievich’
Jet energy scale measurements and their systematic uncertainties are reported for jets measured with the ATLAS detector using proton-proton collision data with a center-of-mass energy of s=13 TeV, corresponding to an integrated luminosity of 3.2 fb-1 collected during 2015 at the LHC. Jets are reconstructed from energy deposits forming topological clusters of calorimeter cells, using the anti-kt al
The production of opposite-charge W-boson pairs in proton–proton collisions at s=13 TeV is measured using data corresponding to 3.16 fb−1 of integrated luminosity collected by the ATLAS detector at the CERN Large Hadron Collider in 2015. Candidate W-boson pairs are selected by identifying their leptonic decays into an electron, a muon and neutrinos. Events with reconstructed jets are not included
Two methods are commonly used to study the diet of nestling passerines: the neck collar method and faecal sampling. Most studies apply either method, however, few methodological studies comparing both methods exist and are mainly limited to farmland birds. Furthermore, existing methodological studies only include high-level taxonomic diet categories. Here, we compared both methods using two wetlan
A search is conducted for new resonant and non-resonant high-mass phenomena in dielectron and dimuon final states. The search uses 36.1 fb−1 of proton-proton collision data, collected at s=13 TeV by the ATLAS experiment at the LHC in 2015 and 2016. No significant deviation from the Standard Model prediction is observed. Upper limits at 95% credibility level are set on the cross-section times branc
Providing sensory feedback for myoelectric prosthetic users can not only increase the manipulation ability but can also introduce a feeling of embodiment. Previous research has demonstrated the feasibility of providing mechanotactile or vibrotactile feedback on the remaining stumps of amputees. To improve the recognition rate and reduce mental work load when identifying stimulation patterns, we pr
In this paper, a nano-scratch testing approach was used to measure and evaluate the abrasion wear resistance of high-chromium white cast irons in order to understand the wear mechanism in the interaction between the high-chromium white cast iron and the cBN cutting tool during the machining process. Scratch testing was performed on a nanoindentation instrument using a diamond indenter as the scrat
In order to fulfil the requirements of available energy resources, there is a great need to obtain a sustainable and environmentally friendly energy utilization using combustion processes. In order to do this, it is of utmost importance to utilize non-intrusive diagnostic techniques with high spatial and temporal resolution which can characterize the combustion process and also validate combustion
The objective of this review is to examine how drug spending in different age groups changed during the 1990s. Time series analysis of registered data on prescription drug spending were performed, along with two decompositions, one of which was spending in three components: price, quantity (defined daily dose) and residual. The size of the residual is a measure of the impact of changes in drug tre
The aim is to investigate the effect of availability and level of detail of data on cost estimates of alcohol consumption. Using the recent Swedish cost of alcohol study as baseline, limitations on data are applied, forming two models. The costs of alcohol in Sweden are re-estimated in the two models and compared to the baseline, to establish the magnitude and direction of the bias resulting from
