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Several studies have found a clustering of dementia in relatives of patients with frontotemporal dementia (FTD). This study analysed the familial aggregation of FTD specifically as well as the occurrence of dementia in general in first-degree relatives of patients with FTD. A family history study was carried out on 478 first-degree relatives of 74 index patients suffering from FTD. Cases of organi

A sequence in the Upper Silurian Oved-Ramsasa Group in Scania, Sweden has been investigated sedimentologically and geochemically. This sequence represents a regressive marine succession. The sedimentary structures and the rapid vertical changes in lithologies and the lateral variability of beds indicate a tide-dominated sedimentation in a shallow epeiric sea, where even small oscillations in sea w

We have investigated the oxidation/reduction behavior of dome-shaped three-dimensional islands of Ge on Si(001) grown by ultrabigh vacuum chemical vapor deposition. The oxidation was done by exposing the surfaces to H2O steam in N-2. The reduction was done by H-2, which selectively reduces only the GeO2. The results of the oxidation/reduction processes under varying conditions were analyzed by hig

Carcinomas of the head and neck typically exhibit complex chromosome aberrations but the underlying mutational mechanisms remain obscure. Evaluation of cell division dynamics in low-passage cell lines from three benign and five malignant head and neck tumours revealed a strong positive correlation between multipolarity of the mitotic spindle and the formation of bridges at anaphase in both benign

Driver comprehension and acceptance of the active accelerator pedal (AAP) after long-term use were evaluated in a large-scale Swedish trial held in 2000-2002. The system was installed in the cars of 281 test drivers who then used it for between six months and a year. The participants' responses, elicited by questionnaires in the end of the trial, showed a positive rating of the concept of the AAP,

Human activity often causes a decline in the local density of plant populations. Below some critical lower density, populations may suffer a progressive decline in reproductive success because of the difficulties associated with finding suitable mates. Therefore, to conserve endangered plant species it is necessary to understand in greater detail how changes in population density affect different

Dendritic cells (DCIs) possess a potent ability to modulate and activate specific T-cell responses to allergens, which play a pivotal role in allergic inflammation by secreting cytokines and other mediators. However, the molecular mechanisms by which allergen-challenged DCs regulate specific T-cell responses are still not well characterized. This study aims at elucidating the molecular mechanisms

The robustness of a dual-beam, optical null, Fourier-transform near-infrared (FTNIR) spectrometer was investigated by means of online, near-infrared measurements and predictions of urea concentrations in spent dialysate during hemodialysis treatment. Simple multivariate calibration using a few factors based on a small number of prepared samples provided stable and accurate predictions over a perio

Trends in energy intensities for 31 countries are evaluated, over the period from 1950 to 1988, using a purchasing power parity-based GDP measure and United Nations energy statistics. With non-commercial energy included, the energy intensities of low income countries are similar to those of high income countries. Energy intensities have decreased for 15 out of the 31 countries studied. The analysi

This article describes a study where laboratory and theoretical work on the fundamental hygro-mechanical behaviour of wood is applied on convective drying of sawn timber. A material model describing the behaviour of wood during drying is used to simulate drying stresses in timber. Cross-sections containing heartwood, sapwood and a combination of both are studied. Simulations are compared with meas

A new relationship between the roughness height and the main hydrodynamic and sediment parameters for plane beds under oscillatory conditions is presented. In order to derive such a relationship, a large data base encompassing plane-bed experiments was compiled from previous investigations and analyzed. Different methods to estimate the roughness height were investigated. Comparisons between the d

The Southern Ocean is split into several biogeographical provinces between convergence zones that separate watermasses of different temperatures. Recent molecular phylogenies have uncovered a strong phylogeographic structure among rockhopper penguin populations, Eudyptes chrysocome sensu lato, from different biogeographical provinces. These studies suggested a reclassification as three species in

Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor particularly associated with tendons and aponeuroses. The cytogenetic hallmark is the translocation t(12;22)(q13;q12) resulting in a chimeric EWS/ATF1 gene in which the 3'-terminal part of EWS at 22q is replaced by the 3'-terminal part of ATF1 at 12q. To date, only 13 cases of CCS have been analyzed for fusion genes at the transcriptio

Streptomycetes grow by cell wall extension at hyphal tips. The molecular basis for such polar growth in prokaryotes is largely unknown. It is reported here that DivIVA SC , the Streptomyces coelicolor homologue of the Bacillus subtilis protein DivIVA, is essential and directly involved in hyphal tip growth and morphogenesis. A DivIVA SC -EGFP hybrid was distinctively localized to hyphal tips and l

To study which individual characteristics and environmental factors correlate with fear of moving outdoors and whether fear of moving outdoors predicts development of mobility limitation. Observational prospective cohort study and cross-sectional analyses. Community and research center. Seven hundred twenty-seven community-living people aged 75 to 81 were interviewed at baseline, of whom 314 took

HIV particles that use the chemokine receptor CXCR4 as a coreceptor for entry into cells (X4-HIV) inefficiently transmit infection across mucosal surfaces [1], despite their presence in seminal fluid and mucosal secretions from infected individuals [2] [3] [4]. In addition, although intestinal lymphocytes are susceptible to infection with either X4-HIV particles or particles that use the chemokine