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Using transgenic mouse models of breast cancer that ablate Src homology and collagen A ( ShcA) expression or oncogene-coupled ShcA signaling, we previously showed that this adaptor is critical for mammary tumor onset and progression. We now provide the first evidence that ShcA regulates mammary tumorigenesis, in part, through its ability to regulate the adaptive immune response. Inactivation of Sh

The aim of the study was to evaluate the feasibility of tailored and dose-dense epirubicin and cyclophosphamide followed by docetaxel as adjuvant breast cancer therapy. Material and methods. Patients with node-positive breast cancer received either four cycles of biweekly and tailored EC (epirubicin 38-60-75-90-105-120 mg/m(2), cyclophosphamide 450-600-900-1200 mg/m(2)) followed by four cycles of

In magnetic resonance imaging (MRI), the balanced steadystate free precession (bSSFP) pulse sequence has shown to be of great interest, due to its relatively high signal-to-noise ratio in a short scan time. However, images acquired with this pulse sequence suffer from banding artifacts due to offresonance effects. These artifacts typically appear as black bands covering parts of the image and they

Abstract in Danish Hvad er det der ‘kvæær’ egentlig? Dette spørgsmål synes altid at klistre til tekster og praksisser med queer som udgangspunkt, og dets svar bliver ofte tøvende, hængende i luften – ambivalent, utydeligt og afhængig af kontekst. For den som stiller spørgsmålet, bliver svaret næsten aldrig så konkret som hen håbede på. Og for den som forventes at svare, bliver diffuse henvisninger

This paper aims at validation of an iterative receiver for multiple-input multiple-output with orthogonal frequency division multiplexing (MIMO-OFDM) systems using real-measurement channel data from an indoor scenario. The receiver performs iterative multi-user detection (MUD) and Channel Estimation (CE) via soft information from the single- user decoders. The channel measurements were performed f

Domain polarization switching in potassium dihydrogen phosphate (KH2PO4, KDP) induced by a propagating strain wave has been observed with time-resolved x-ray diffraction. A pulsed electric field with amplitude of 6 kV/cm and duration of 1 mu s was applied along the crystallographic c axis. The field-induced strain waves emanating from the sample surfaces are the result of the converse piezoelectri

As a global society we are entering an era where land areas and land-based resources are coming to the fore once again for capital accumulation and economic growth, for the first time since the end of the 18th century when Malthus forecasted a contradiction between population growth and agricultural output. That constraint on economic growth, imposed by limited land areas, was overcome by the comb

Background: Musculoskeletal disorders (MSDs) are a major reason for impaired work productivity and sick leave. In 2009, a national rehabilitation program was introduced in Sweden to promote work ability, and patients with MSDs were offered multimodal rehabilitation. The aim of this study was to analyse the effect of this program on health related quality of life, function, sick leave and work abil

The ionization signals in the liquid argon of the ATLAS electromagnetic calorimeter are studied in detail using cosmic muons. In particular, the drift time of the ionization electrons is measured and used to assess the intrinsic uniformity of the calorimeter gaps and estimate its impact on the constant term of the energy resolution. The drift times of electrons in the cells of the second layer of

The Swedish epistemic auxiliary "verka" 'seem to' has developed since the end of the 19th century from an active causative meaning 'have the effect', 'cause'. Its use with a main verb in the infinitive has increased in the latter half of the 20th century. The deveolpment is studied as a case of grammaticalization.

Popular Abstract in Swedish Syftet med denna studie var att undersöka hur tvångsvård av alkoholmissbrukare upplevs av den som döms till det. Majoriteten av dessa personer är negativa till tvångsvård. I studien har också tagits hänsyn till att resultaten ses utifrån ett bredare perspektiv. Det som också undersökts är alkoholmissbruk generellt, varför klienterna dricker i den utsträckning de gör samThe aim of this study was to investigate how compulsary treatment of alcohol abuse is experienced by persons forced to submit to it, the majority of whom are negative in their attitude toward treatment of this sort. The importance of considering the resluts obtained not in isolation but within a larger context is emphasized. Among the elements of this context examined are alcohol abuse generally,

Aquaporins are water channel proteins belonging to the major intrinsic protein (MIP) superfamily of membrane proteins. More than 150 MIPs have been identified in organisms ranging from bacteria to animals and plants. In plants, aquaporins are present in the plasma membrane and in the vacuolar membrane where they are abundant constituents. Functional studies of aquaporins have hitherto mainly been