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We have used the density functional B3LYP method to study the effect of hydrogen bonds from the histidine ligand in various haem proteins to carboxyl groups or to the carbonyl backbone. Hydrogen bonds to carbonyl groups (encountered in globins and cytochromes, for example) have a small influence on the geometry and properties of the haem site. However, hydrogen bonds to a carboxyl group (encounter
Aim: To explore the prevalence of atrial fibrillation in patients with hypertension and type 2 diabetes and to identify possible mechanisms for the development of atrial fibrillation. Methods: A community-based, cross-sectional observational study was conducted in the primary health care in Skara, Sweden, and 1739 subjects (798 men, 941 women) were surveyed. Patients were categorized as those wit
Interactive development environments (IDEs) increase programmer productivity, but unfortunately also the burden on language implementors since sophisticated tool support is expected even for small domain-specific languages. Our goal is to alleviate that burden, by generating IDEs from high-level language specifications using the JastAdd meta-compiler system. This puts increased tension on scope re
Chemical cues from piscivorous fish and prey alarm substances often cause rapid fright responses in prey. However little is known of how piscivore-related chemical cues affect prey behaviour over periods longer than a few hours. Here we have investigated how chemical cues from piscivorous northern pike, Esox lucius, affect habitat choice and diel activity of crucian carp, Carassius carassius, over
The industrial formulations for the thermodynamic properties of water/steam, which are approximations of the scientific one, are intended to be used in applications where computational speed is of importance, such as in power plant modelling and control. The traditional methods for implementing these tables in software imply either the use of polynomial algorithms, which demand long iteration time
Calls for more robust societal emergency management capacities have grown shriller as the range of societal vulnerabilities widens. The development of workable plans is recognised as one means to increase capacity. However, scepticism persists that plans serve any significant function in guiding organisational emergency management. Plans nevertheless remain a de facto requirement for most organisa
ntroduction: Correlation function analysis was applied to endocardial electrograms to investigate conduction patterns along the coronary sinus (CS) during sinus rhythm (SR) and atrial tachycardias. Methods and Results: Eighteen recordings were obtained from 14 patients suffering from supraventricular tachycardias. Five atrial fibrillation(AF) recordings were compared to 10 SR recordings and 3 ecto
We have analyzed the development of aortic and coronary atherosclerosis over 40 years in native and non-native males of Yakutsk by comparing the data obtained in 1963-1965, 1985-1987 and 2001-2003. The research was carried out in compliance with the WHO program for the atherosclerosis epidemiology studies using autopsy material. Subjects (361 natives and 692 non-natives) included in the research d
Objectives:To compare the six-year outcome of a multidisciplinary rehabilitation program with continued care within primary care in terms of health-related quality of life and cost-effectiveness. Furthermore, predictors of total costs to society were examined. Methods:A prospective, matched, controlled, six-year follow-up was designed. The study included 236 patients (42 men, 194 women) nineteen
This phase 2 study evaluated the safety and efficacy of alemtuzumab in 22 patients with advanced mycosis fungoides/Sezary syndrome (MF/SS). Most patients had stage III or IV disease, reduced performance status, and severe itching. The overall response (OR) rate was 55%, with 32% of patients in complete remission (CR) and M in, partial remission (PR). Sezary cells were cleared from the blood in 6 o
In this article we discuss the notion of ‘interaction’, ‘participation’ and ‘the public’ in artistic work, specifically within the context of the exhibition The Invisible Landscapes (curated by Miya Yoshida, Malmö Konstmuseum, 2003) and etherSound (created by Henrik Frisk), a sound installation displayed in that exhibition. In this work the audience is invited to participate in the creation of new
The aims of this study were to analyse (1) whether informal care, provided by children or grandchildren to their elderly parents, and formal care are substitutes or complements, and (2) whether this relationship differs across Europe. The analyses Were based on cross-sectional data from the newly developed SHARE (Survey of Health, Ageing, and Retirement in Europe) database. We found (1) that infor
The highly malignant brain tumor, glioblastoma multiforme (GBM), is difficult to fully delineate during surgical resection due to its infiltrative ingrowth and morphological similarities to surrounding functioning brain tissue. Selectiveness of GBM to 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PpIX) is reported by other researchers to visualize tumor margins under blue light microsco
Background: Lymphedema is a chronic, debilitating condition that has traditionally been seen as refractory or incurable. Recent years have brought new advances in the study of lymphedema pathophysiology. as well as diagnostic and therapeutic tools that are changing this perspective. Objective: To provide a systematic approach to evaluating and managing patients with lymphedema. Methods: We perform
Purpose: To examine how the library user emerges in the context of the LibQUAL+ application in Sweden in 2004. Design/methodology/approach: The paper examines the following aspects: how the information control dimension is depicted in the results of the Swedish participants; how the information control dimension compares between the Swedish implementation and other libraries; the "new user" as he
The Euglycemic Hyperinsulinemic Clamp (EHC) is the most widely used experimental procedure for the determination of insulin sensitivity. In the present study, 16 subjects with BMI between 18.5 and 63.6 kg/m(2) have been studied with a long-duration (5 hours) EHC. In order to explain the oscillations of glycemia occurring in response to the hyperinsulinization and to the continuous glucose infusion
The mechanism of ascorbate oxidation was studied in rat liver microsomes. A continuous consumption of the added ascorbate was observed, which was accompanied with a prompt appearance of ascorbyl free radical and dehydroascorbate. Microsomes sustained steady-state level of ascorbyl free radical and dehydroascorbate till ascorbate was present in the medium. Ascorbyl free radical formation was dimini
BACKGROUND: To determine normal blood levels of brain-specific proteins S-100 and neuron specific enolase (NSE) in healthy newborns and their mothers following uncomplicated birth. METHODS: Umbilical artery and vein blood and maternal venous blood was collected at 112 consecutive uncomplicated deliveries. Venous blood samples were taken from 18 of the neonates 3 days after birth. S-100 and NSE wer
BACKGROUND: Previous studies imply that human pancreatic cancer cells have a wide heterogeneity and their exposure to various agents may give unpredictable results in clinical situations. MATERIALS AND METHODS: The cell lines LPC-3, -5 and -10, established from primary cultures of pancreatic adenocarcinoma, were exposed to 5 microM of AAT or its C-terminal peptide C-36 for 24 hours and analysed fo
