Filetype
3′-Phosphoadenosine-5′-phosphosulfate (PAPS) is a key player in the sulfation of biomolecules, but methods for selective measurements are lacking. A liquid chromatography–mass spectrometry (LC–MS) approach for measuring PAPS was developed. A central feature of the method was employing hydrophilic interaction liquid chromatography (HILIC), which is highly suited for separating very polar/charged co
In order to be able to realistically and consistently elucidate and subsequently simulate the load–displacement behavior of single-dowel connections, the material behavior of the individual components, namely steel dowels and wood, needs to be investigated. The behavior of slotted-in, single-dowel steel-to-laminated veneer lumber (LVL) connections with dowel diameters of 12 and 20 mm is thoroughly
We present a digital-to-time converter (DTC)-assisted fractional-N wide-bandwidth all-digital PLL (ADPLL). It employs a MASH ΔΣ time-to-digital converter (TDC) to achieve low in-band phase noise, and a wide-tuning range digitally-controlled oscillator (DCO). Fabricated in 40nm CMOS, the ADPLL consumes 10.7 mW while outputting 1.73 to 3.38 GHz (after a ÷2 division) and achieves better than -109 dBc
This study reports the prevalence and prognostic impact of right bundle branch block (RBBB) and left bundle branch block (LBBB) in the admission electrocardiogram (ECG) of comatose survivors of out-of-hospital cardiac arrest (OHCA). The present study is part of the predefined electrocardiographic substudy of the prospective randomized target temperature management trial, which found no benefit of
This paper presents a model that uses only pH, alkalinity, and temperature to estimate the concentrations of major ions in rivers (Na+, K+, Mg2+, Ca2+, HCO3 -, SO4 2-, Cl-, and NO3 -) together with the equilibrium concentrations of minor ions and heavy metals (Fe3+, Mn2+, Cd2+, Cu2+, Al3+, Pb2+, and Zn2+). Mining operations have been increasing, which has led to changes in the pollution loads to r
Monoclonal antibody (mAb) based affinity resins usually suffer from low binding capacity, most probably as a result of steric hindrance by the large 150 kDa size of the mAb and a random immobilisation approach. The present work investigates the influence of a variety of factors on dynamic binding capacity (DBC) such as pore/ligand size ratio, accessibility of ligand and ligand density. The effect
