Strategies for expanding hematopoietic stem cells (HSCs) include coculture with cells that recapitulate their natural microenvironment, such as bone marrow stromal stem/progenitor cells (BMSCs). Plastic-adherent BMSCs may be insufficient to preserve primitive HSCs. Here, we describe a method of isolating and culturing human BMSCs as nonadherent mesenchymal spheres. Human mesenspheres were derived

Popular Abstract in Swedish Under 1700- och 1800-talet omvandlades det svenska jordbruket som en del av en euro¬peisk utveckling som uppvisar övergripande likheter. De genomgripande förändringarna och deras betydelse för den långsiktiga samhällsutvecklingen motiverar att man talar om en agrar revolution. Trots övergripande likheter rymde emellertid den agrara revolutionen såväl regio-nala som lokaThe great transformation of Swedish agriculture in the 18th and 19th centuries was part of a European-wide development sharing similar characteristics. While researchers agree that extensive agro-technological, social and institutional changes took place, opinions differ with regards to the causes, spread, timing and sequence of events. Through a systematic study of agricultural production, land u

Popular Abstract in Swedish I min avhandling har jag tittat på möjligheten att göra om mänskliga hudceller direkt till dopaminerga nervceller. Dessa uppvisar flera egenskaper tillskrivna de dopaminerga nervceller vi hittar i hjärnan. Jag tittar även på möjligheten att transplantera dessa som hudceller i hjärnan på råttor och sen göra om dom till nervceller när de är på plats. Dessa celler bildar nCellular reprogramming is when one cell is changed into another. This involves structural modifications on the DNA of a cell resulting in a transcriptional change. This occurs naturally during development when early pluripotent cells gradually differentiate into more specialized cells that finally result in a complete organism. This is a finely orchestrated event that includes both extrinsic and i

A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S p

Background: In recent years, several primary care databases recording information from computerized medical records have been established and used for quality assessment of medical care and research. However, to be useful for research purposes, the data generated routinely from every day practice require registration of high quality. In this study we aimed to investigate (i) the frequency and vali

Understanding polymorphism in pharmaceutical ingredients is a long-standing challenge in formulation science. A well-known example is paracetamol, C8H9NO2. The marketed stable form I crystallizes with corrugated molecular layers. In contrast, form II, which is thermodynamically favorable at high pressures, has relatively planar layers that can slip over each other without difficulty, but is metast

Background: Despite a decreasing incidence of peptic ulcer disease, most previous studies report a stabile incidence of ulcer complications. We wanted to investigate the incidence of peptic ulcer complications in Sweden before and after the introduction of the proton pump inhibitors (PPI) in 1988 and compare these data to the sales of non-steroid anti-inflammatory drugs ( NSAID) and acetylsalicyli

An article about city fires.

There is a lack of detailed information on the impact of organic feeding regulation on the health and well-being of cows. This has become especially important since January 2008 when the EU required 100% organic ration for organic dairy herds. The aim of this investigation was to determine and compare the levels of essential elements in organic and conventional dairy herds, and to associate them w

Purpose To compare drug treatment changes in older hip fracture patients with and without multi-dose drug dispensing (MDD) after discharge from hospital. Methods Hip fracture patients (aged 65 years or older) for whom the same prescribing procedure was used at discharge and at the 6-month follow-up were extracted from two patient cohorts consecutively recruited in 2008 (n=100) and 2009 (n=99), res

Pseudorapidity gap distributions in proton-proton collisions at root s = 7 TeV are studied using a minimum bias data sample with an integrated luminosity of 7.1 mu b(-1). Cross sections are measured differentially in terms of Delta eta(F), the larger of the pseudorapidity regions extending to the limits of the ATLAS sensitivity, at eta = +/- 4.9, in which no final state particles are produced abov

Allergen-specific immunotherapy (AIT) induces tolerance and shifts the Th2 response towards a regulatory T-cell profile. The underlying mechanisms are not fully understood, but dendritic cells (DC) play a vital role as key regulators of T-cell responses. DCs interact with allergens via Fc receptors (FcRs) and via certain C-type lectin receptors (CLRs), including CD209/DC-SIGN, CD206/MR and Dectin-

Background: A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort. Methods: In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 contr

En analys av kvinnors myndighetsansökningar i Sverige under 1800-talet.

The association of Helicobacter pylori with gastroduodenal diseases is well established. The mode of transmission of the organism is still unclear, although the faecal-oral route has been proposed. H. pylori has been detected in gastric antrum, dental plaques, faeces and water. In the light of these studies we attempted to detect H. pylori in antral biopsies, dental plaques, and stool specimens of

Popular Abstract in Swedish I Immi Lundins avhandling Att föra det egna till torgs står 1960-, 1970- och 1980-talen i fokus. Tre kvinnliga författares debutromaner, en från varje decennium, undersöks och sätts i relation till de förändrade positionerna i den offentliga kvinno- och litteraturdebatten under trettioårsperioden. Frågan som avhandlingen söker svar på gäller romanernas samspel med tillkThe Swedish debate both on the role of literature and on the social position of women underwent rapid change during the thirty years from 1960 to 1990. In Bringing the Personal to Market: Narrative, Subject-Matter and Contemporary History in the First Novels of Kerstin Strandberg, Enel Melberg and Eva Adolfsson, the debut novels of three female authors’ are close-read from a thematic and narratolo

The microarchitecture of trabecular bone adapts to its mechanical loading environment according to Wolff's law and alters with age. Trabecular bone is a metabolically active tissue, thus, its molecular composition and microarchitecture may vary between anatomical locations as a result of the local mechanical loading environment. No comprehensive comparison of composition and microarchitecture of t

Nanoscale near-infrared photodetectors are attractive for their potential applications in integrated optoelectronic devices. Here we report the synthesis of GaSb/GaInSb p-n heterojunction semiconductor nanowires for the first time through a controllable chemical vapor deposition (CVD) route. Based on these nanowires, room-temperature, high-performance, near-infrared photodetectors were constructed