We report on the development of a method based on recombinant yeast Saccharomyces cerevisiae to produce nonivamide, a capsaicinoid and potent agonist of the pain receptor TRPV1. Nonivamide was produced in a two-step batch process where yeast was i) grown aerobically on glucose and ii) used to produce nonivamide from vanillin and non-anoic acid by bioconversion. The yeast was engineered to express

In transplants of embryonic striatal cells placed into the excitotoxically lesioned rat striatum (a model of Huntington's disease), as many as 60 to 90% of the grafted cells are believed to die. Caspase activation is part of a cascade of events that can lead to apoptosis. We investigated the effect of the caspase inhibitor acetyl-tyrosinyl-valyl-alanyl-aspartyl-chloromethylketone (Ac-YVAD-cmk) on In transplants of embryonic striatal cells placed into the excitotoxically lesioned rat striatum (a model of Huntington's disease), as many as 60 to 90% of the grafted cells are believed to die. Caspase activation is part of a cascade of events that can lead to apoptosis. We investigated the effect of the caspase inhibitor acetyl-tyrosinyl-valyl-alanyl-aspartyl-chloromethylketone (Ac-YVAD-cmk) on

As structural components of the glycocalyx, heparan sulfate proteoglycans (HSPGs) are involved in multiple pathophysiological processes at the apex of cell signaling cascades, and as endocytosis receptors for particle structures, such as lipoproteins, extracellular vesicles, and enveloped viruses, including SARS-CoV-2. Given their diversity and complex biogenesis regulation, HSPGs remain understud

A large proportion of grafted striatal neurons die, and mechanisms by which they succumb may involve excitotoxicity and oxidative stress. We investigated the effects of pretreatment of the graft tissue with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)dizocilpine hydrogen maleate (MK-801) and lipid peroxidation inhibitor lazaroid U-83836E on the survival of transplanted striatal neurons.

This chapter exemplifies rodent models of Parkinson's disease that have been used in transplantation studies and recounts basic transplantation methods. It describes morphological features of grafts containing dopamine neurons and focuses on the role of nigral grafts that are implanted homotopically in the mesencephalon, for example, near their location in the normal brain. The neurotoxin 6-hydrox

Utredningens uppdrag är att undersöka vilka åtgärder som behövervidtas för att skapa en långsiktig och hållbar rättslig reglering för utlämnande av försäljningsstatistik som avser läkemedel för människor.Behovet av en mer ändamålsenlig reglering har aktualiserats som enföljd av att E-hälsomyndigheten och Socialstyrelsen efter rättsligaställningstaganden, med hänsyn till bestämmelsen om statistikse

Over the last decades, there has been a rapid increase of the number of climate change initiatives outside the UNFCCC. In research this is referred to as ‘institutional fragmentation’, and it encompasses a wide range of public, private and hybrid initiatives, at various levels of governance. This development is extensively discussed in the IPCC Fifth Assessment Report AR5. Chapters 13-16 of the Wo

Översiktlig artikel om hur spanska sjukan 1918 drabbade Lunds universitet och särskilt dess studenter samt om hur vissa professorer i medicin förhöll sig till den nya smittan.

UNLABELLED: Lymphedema is a chronic, debilitating disease that has been described as the largest breast cancer survivorship burden. Debulking surgery has been shown to improve extremity volume, improve patient quality of life, and decrease the incidence of cellulitis in the literature. This procedure is routinely covered in numerous other developed countries, yet it is still inconsistently covered

Paleoklimatologi – läran om hur klimatet utvecklats genom jordens historia – ger oss referensramar för att sätta dagens klimat och möjliga framtida klimatförändringar i ett historiskt perspektiv. Till exempel visar nya analyser av historiska klimatarkiv att för norra halvklotet var perioden 1983-2012 sannolikt den varmaste på 1400 år. Vi ser även att vid den senaste värmeperioden, för 125 000 år s

PURPOSE Heart failure (HF) is a potentially life-threatening complication of treatment for childhood cancer. We evaluated the risk and risk factors for HF in a large European study of long-term survivors. Little is known of the effects of low doses of treatment, which is needed to improve current treatment protocols and surveillance guidelines.METHODSThis study includes the PanCareSurFup and ProCa

Aim: The aim is to identify important factors for immigrants’ health and well-being and for their use (or non-use) of primary health care (PHC) and other non-specialised services, and for possible ways that PHC can support healthy ageing of immigrants.Background: Older persons are an increasing share of the immigrant population in the global north, frequently in contact with various forms of healt

FN:s mellanstatliga klimatpanel IPCC lyfter i sin femte stora rapport (”Assessment Report 5”, AR5) fram att för att den långsiktiga globala uppvärmningen ska kunna begränsas till mindre än 2 grader, behöver de kumulativa växthusgasutsläppen begränsas till en viss maximal mängd. För att sannolikt uppnå en sådan klimatstabilisering uppgår det totala utsläppsutrymmet, det vill säga mängden kol som få

Den observerade globala uppvärmningen sedan industrialismens början uppgår nu till nästan en grad, havsnivån har stigit och Arktis havsis och glaciärer smälter. Hur stor klimatförändringen och dess effekter till slut blir beror främst på utvecklingen av de klimatpåverkande utsläppen, speciellt koldioxid. De globala utsläppen behöver över tid begränsas till 3700 miljarder ton koldioxidekvivalenter,

Many countries use tax legislation as a cultural policy instrument. This includes tax incentives for arts organizations and their benefactors. This chapter analyzes what a tax incentive is, what its positive and negative sides are, and how governments use it to support the arts and cultural organizations. Tax incentives for giving, the possibility of paying tax with art, reduced value added tax ra