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Li Z, Alam S, Wang J, Sandstrom CS, Janciauskiene S, Mahadeva R. Oxidized alpha(1)-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema. Am J Physiol Lung Cell Mol Physiol 297: L388-L400, 2009. First published June 12, 2009; doi:10.1152/ajplung.90373.2008.-alpha(1)-Antitrypsin ( AT) is a major elastase inhibitor within the lun

Among the available agricultural byproducts, corn stover, with its yearly production of 10 million t (dry basis), is the most abundant promising raw material for fuel ethanol production in Hungary. In the United States, more than 216 million t of corn stover is produced annually, of which a portion also could possibly be collected for conversion to ethanol. However, a network of lignin and hemicel

Human disturbance can be a severe problem for some animal species. Behavioural ecology theory predicts that sensitivity to mortality risks, and thereby to disturbance, will be related to life-history characteristics. Long-lived species with low reproductive rates are expected to have a high cost of predation and therefore avoid risks strongly. In this paper we quantify the effect of roads on the A

The recent dramatic decline in farmland biodiversity is often attributed to agricultural intensification and structural changes in the agricultural landscape. One suggested farm practice seen to benefit biodiversity and reverse declines is organic farming. Because organic farming is viewed as a more sustainable form of agriculture it is currently subsidized by European agri-environment schemes. Ho

BACKGROUND. High resolution spatial details of the distribution of activity in three dimensions is required to evaluate the localization and dosimetric properties of radiolabelled monoclonal antibodies in tumors and normal tissues. Planar imaging of small animals with a resolution of 5-10 mm is usually the imaging modality of choice. The authors investigated high resolution single-photon emission

Species of Phragmoceras in the Silurian of Gotland and Britain are reviewed and revised. One new species P. exaggeratus is described from the Ludlow Series of the Welsh Borderland. There are comments on the broader distribution of the genus and on its mode of life.

Using an approach of combining Fourier transform infrared spectroscopy with resonant illumination from a secondary external light source, we have measured the photocurrent (PC) for multiple layers of self-assembled InAs dots embedded in a matrix of InP. Without external illumination, we observe photoexcitation of electrons from bound states in the dots to the InP barrier. By additional illuminatio

Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunizati

A plasma source free from characteristic emission lines is described, based on laser irradiation of a water jet in a helium atmosphere. Various key aspects of the laser interaction are presented along with practical characterization of the observed isotropic ~4–10 keV x-ray emissions, measurements of which indicate subpicosecond duration. Observations are consistent with a vacuum heating plasma me

PURPOSE: Prostate-specific antigen (PSA) defined biochemical recurrence (BCR) of prostate cancer is widely used for reporting the outcome of radical prostatectomy (RP). A standardized BCR definition is lacking, and overall progression-free probability and risk of subsequent metastatic disease progression may vary greatly depending on the PSA criterion used. Ten definitions of BCR were evaluated to

Real-time PCR is fast, sensitive, specific, and can deliver quantitative data; however, two disadvantages are that this technology is sensitive to inhibition by food and that it does not distinguish between DNA originating from viable, viable nonculturable (VNC), and dead cells. For this reason, real-time PCR has been combined with a novel discontinuous buoyant density gradient method, called flot

In platelets, coagulation cofactor V is stored in complex with multimerin 1 in alpha-granules for activation- induced release during clot formation. The molecular nature of multimerin 1 factor V binding has not been determined, although multimerin 1 is known to interact with the factor V light chain. We investigated the region in factor V important for multimerin 1 binding using modified enzyme-li

Objective: To evaluate the internal consistency of the Hip disability and Osteoarthritis Outcome Score-Physical Function Short-form (HOOS-PS) and the Knee injury and Ostecarthritis Outcome Score-Physical Function Short-form (KOOS-PS) in total hip replacement (THR) and total knee (TKR) replacement. Construct validity and responsiveness were compared to the Western Ontario McMaster Universities' Ost

Water soluble plasma proteins were fractionated from hen's egg yolk, and the molecular weight and pI of the most abundant protein species were characterized with gel electrophoresis. The proteins were identified by mass spectrometry. The protein fraction was used to produce oil-in-water emulsions, both at various protein concentrations and at various pH values, and the surface load was determined

Besides the bioavailability of nitric oxide (NO), downstream guanine monophosphate (cGMP) effector proteins are also considered to play a significant role in penile vascular disease. In animal studies, a downregulation of the cGMP-dependent protein kinase-1 (cGKI) alpha isoform has been linked to erectile dysfunction and diabetes mellitus. So far, the expression of cGKI alpha and beta isoforms has

Spinel ferrites of the form MgxZn1-xFe2O4 ( x = 0. 0.25, 0.50, 0.75, 1.00) were prepared by self-propagating high-temperature synthesis (SHS) from reactions of iron(III), zinc and magnesium oxides, iron powder and sodium perchlorate. The driving force for the reactions is the oxidation of iron powder. Reactions were carried out in the presence of an external magnetic field of 0.2 or 1.1 T. Reactio

Background: Prospective studies have indicated that elevated blood glucose levels may be linked with increased cancer risk, but the strength of the association is unclear. We examined the association between blood glucose and cancer risk in a prospective study of six European cohorts. Methods and Findings: The Metabolic syndrome and Cancer project (Me-Can) includes cohorts from Norway, Austria, an

The interaction of covalently cross-linked double-stranded (ds) DNA gels and cetyltrimethylammonium bromide (CTAB) is investigated. The volume transition of the gels that follows the absorption of the oppositely charged surfactant from aqueous solution is studied. As do other polyelectrolyte networks, DNA networks form complexes with oppositely charged surfactant micelles at surfactant concentrati