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Deposition of basement membrane components, such as collagen IVα5, is associated with altered endothelial cell function in pulmonary hypertension. Collagen IVα5 harbors a functionally active fragment within its C-terminal noncollageneous (NC1) domain, called pentastatin, whose role in pulmonary endothelial cell behavior remains unknown. Here, we demonstrate that pentastatin serves as a mediator of

Pulmonary arterial hypertension (PAH) is a vascular disease that is characterized by elevated pulmonary arterial pressure (PAP) due to progressive vascular remodeling. Extracellular matrix (ECM) deposition in pulmonary arteries (PA) is one of the key features of vascular remodeling. Emerging evidence indicates that the basement membrane (BM), a specialized cluster of ECM proteins underlying the en

Integrated conodont and carbon isotope data is presented from the Telychian (upper Llandovery, lower Silurian) from the Baicaoping section, Yunnan Province, southwestern China. Three conodont zonal units, in stratigraphically ascending order, the Pterospathodus eopennatus Superzone, Pterospathodus celloni Superzone, and the Pterospathodus amorphognathoides amorphognathoides Zone, are recognized in

A method, system and apparatus are disclosed. A network node in communication with a wireless device in a first cell is provided. The network node is configured to receive, from the wireless device, a measurement report associated with the first cell. The network node is further configured to estimate at least one radio resource management, RRM, metric for the first cell and at least one second ce

The Editors’ and Readers’ Choice Awards were established in 2022 to celebrate some of the outstanding articles published every year in the Journal of Comparative Physiology A. The recipients of the 2024 Editors’ Choice Awards were selected based on votes cast by the Editorial Board on articles published in 2023. In the category Original Paper, this distinction goes to ‘Views from ‘crabworld’: the

A method, system and apparatus are disclosed. At least one embodiment includes a wireless device, WD, configured to communicate with a network node, the WD is configured to, and/or includes a radio interface and/or processing circuitry configured to receive a radio resource management, RRM, report configuration. The wireless device is further configured to estimate at least one RRM metric for each

Plant-insect interactions are crucial for sustaining biodiversity and ecosystem functioning in grassland ecosystems. Mutualistic pollination and antagonistic herbivory drive ecological processes such as nutrient cycling, community assembly, and food web stability. However, anthropogenic pressures, including land-use change, agricultural intensification, and environmental stressors like drought and

The effort to electrify society has in recent years resulted in major changes in the transportation sector. Charging time remains a challenge in several applications such as transportation and heavy machinery. A proposed solution that shortens the energy replenishment time and adds flexibility in loading the grid is to battery-swapping: exchanging the depleted battery for a fully charged one. In s

Autoimmune diseases are disorders where the immune system reacts against self-antigens to cause disease. Autoimmune disorders occur in about 5-7% of the population, although many individuals have no symptoms. In all, there are more than 70 different disorders, most of which are uncommon, apart from rheumatoid disease and autoimmune thyroiditis. Autoimmune diseases are clinical syndromes mediated b

Aim: To assess the prevalence of overweight among Swedish 4 year olds in 2018, 2020 and 2022, taking socioeconomic variables into account. Methods: Aggregated regional data on children's body mass index were collected. The socioeconomic Care Need Index (CNI), foreign background, low education, being a single parent, low income and childhood poverty, were assessed. The differences in overweight, in

Mild traumatic brain injury, such as concussion, was once considered self-resolving. However, over the past decade, increased understanding of the short- and long-term impact has led to new guidelines for active management. In this review, we summarise recent findings, covering diagnostic criteria, and management for early and persistent symptoms. Many of the postconcussive symptoms can be treated

Aims/hypothesis: The aim of this study was to clarify the impact of autoimmune disease (AD) comorbidity on the risk and prognosis of latent autoimmune diabetes in adults (LADA). Methods: We used data from a Swedish study comprising newly diagnosed cases of LADA (n=586, stratified into LADAlow and LADAhigh by autoantibody levels), type 2 diabetes (n=2003) and matched control participants (n=2355).

Context. Using emission lines from metals, we investigate the three-dimensional distribution of temperature and chemistry in ultra-hot Jupiters. Aims. Existing observations of WASP-121 b have suggested an underabundance of titanium and titanium oxide in its terminator region. In this study, we aim to determine whether this depletion is global by investigating the dayside emission spectrum. Methods

Introduction: Gram-negative peritonitis (GNP) is associated with significant morbidity in children receiving long-term peritoneal dialysis (PD) and current treatment recommendations are based on limited data. Methods: Analysis of 379 GNP episodes in 308 children (median age 6.9 years, interquartile range [IQR]: 3.0–13.6) from 45 centers in 28 countries reported to the International Pediatric Perit

In this discussion paper, we describe the history of the science and societal action resulting in the mitigation of neurotoxic disorders from exposure to organic solvents at the workplaces in Sweden. When alkyd paints were introduced in large scale in construction painting in the 1960s and 1970s, Scandinavian unions voiced increasing concern as members reported symptoms like headache and vertigo,

Radical cystectomy (RC) for bladder cancer is a complex procedure with an inherent risk of complications and even postoperative mortality. Historically, RC was performed in 44 hospitals in Sweden, which gradually decreased over time, and since a formal regional centralisation of these operations in 2017, cystectomy care is currently provided by nine hospitals. In the Swedish national urinary bladd

Properties of characteristic modes of lossless scatterers breaking time-reversal symmetry are presented utilizing the scattering formulation of characteristic decomposition. Antennas connected to nonreciprocal circuits and moving material bodies are used as numerical examples.

Background: The European Union recently recommended evaluation of the feasibility of organised prostate cancer screening. In Sweden, regional population-based organised prostate cancer testing (OPT) programmes were introduced in 2020. Objective: To describe initial participation rates and diagnostic outcomes. Design, setting, and participants: The three most populated Swedish regions invited all m

Classes focused on biblical reception might seem to some like a “get out of jail” card in the face of ever-threatening questions about the relevance of biblical studies today. To others, such classes look like a cul-de-sac that fails to lead to either renewed interest in the Bible or meaningful pedagogical outcomes. In this short reflection, I tease out chances and challenges that come with teachi

Introduction: In human-agent interaction, trust is often measured using human-trust constructs such as competence, benevolence, and integrity, however, it is unclear whether technology-trust constructs such as functionality, helpfulness, and reliability are more suitable. There is also evidence that perception of “humanness” measured through anthropomorphism varies based on the characteristics of