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A detailed diatom record from Lake Kälksjön, west-central Sweden, reveals two periods of abrupt ecological change correlative with the 8.2 ka cooling event. Using a combination of abrupt step changes and piece-wise linear regressions, the diatom data were analysed for change points over time, and two sudden and large events that are described as regime shifts were detected. During the first event

Investigation into predictors for treatment outcome is essential to improve the clinical efficacy of therapeutic multipotent mesenchymal stromal cells (MSCs). We therefore studied the possible harmful impact of immunogenic ABO blood groups antigens - genetically governed antigenic determinants - at all given steps of MSC-therapy, from cell isolation and preparation for clinical use, to final recip

A period of two and a half millennia separates us from the Classical period of ancient Greece. Nevertheless, looking at ancient Greek medicine from the perspective of modern health economics is an interesting endeavour in that it increases our understanding of the ancient world and provides insights into contemporary society. Ancient Greece is rightly famous for pioneering secular and scientific m

Popular Abstract in Swedish Syftet med sjukgymnastik är att främja hälsa och välbefinnande och hjälpa människor till aktivitet och delaktighet vid sjukdom och skada. Professionen är påverkad av olika hälsoparadigm som hör samman med olika kunskapstraditioner. Det biomedicinska hälsoparadigmet har en dualistisk syn på människan, där normalitet ses som standard, och där syftet är att kurera och korrThe aim of physiotherapy is to promote health and well-being, and to facilitate increased activity and participation of individuals with diseases and injuries. The profession is influenced by different health paradigms which have emerged from different knowledge traditions. The biomedical paradigm of health adopts a dualistic view of mankind in which the normal is regarded as the standard, and the

Asthma and allergic rhinitis are diseases that cause major disability and illness in all ethnic groups and ages. It is well established that allergic rhinitis and asthma are closely linked entities and more than 75 % of the patients with asthma reports concomitant rhinitis. Asthma is also closely associated to bronchial hyperresponsiveness, and a large part of patients with rhinitis alone show a r

The concept of “style of thought” or Denkstil is today probably primarily associated with the Polish microbiologist and philosopher of science Ludwik Fleck and his writings from the 1930s. It was however used quite extensively already by Karl Mannheim in his writings on the sociology of knowledge from the 1920s. Quite interestingly, the concept of style of thought was also used twice by Rudolf Car

Desiccation of the Sahara since the middle Holocene has eradicated all but a few natural archives recording its transition from a "green Sahara" to the present hyperarid desert. Our continuous 6000- year paleoenvironmental reconstruction from northern Chad shows progressive drying of the regional terrestrial ecosystem in response to weakening insolation forcing of the African monsoon and abrupt hy

Background: The yeast Saccharomyces cerevisiae provides unique opportunities to study roles and regulation of aqua/glyceroporins using frontline tools of genetics and genomics as well as molecular cell and systems biology. Scope of review: S. cerevisiae has two similar orthodox aquaporins. Based on phenotypes mediated by gene deletion or overexpression as well as on their expression pattern, the y

Recordings of the acoustic activity of free-swimming groups of echolocating dolphins increase the likelihood of collecting overlapping click trains, originating from multiple individuals, in the same set of data. In order to evaluate the click properties of each individual based on such recordings it is necessary to identify which clicks originate from which animal. This paper suggests a computati

In this paper, we review our efforts to use quantum mechanical (QM) methods to improve free-energy estimates of the binding of drug candidates to their receptor proteins. First, we have tested the influence of various implicit solvation models on predictions of the ligand-binding affinity. The accuracy of implicit solvation models strongly depend on the parameterisation, but also on the magnitude

The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of root s = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb(-1). The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b

Despite our fine-grain anatomical knowledge of the cerebellar cortex, electrophysiological studies of circuit information processing over the last fifty years have been hampered by the difficulty of reliably assigning signals to identified cell types. We approached this problem by assessing the spontaneous activity signatures of identified cerebellar cortical neurones. A range of statistics descri

We have developed a technique so that both transmission electron microscopy and microphotoluminescence can be performed on the same semiconductor nanowire over a large range of optical power, thus allowing us to directly correlate structural and optical properties of rotationally twinned zinc blende InP nanowires. We have constructed the energy band diagram of the resulting multiquantum well heter

This study was designed to investigate attitudes to and incentive for reporting adverse drug reactions (ADRs) in general and towards nurses as reporters of ADRs in particular in a sample of hospital physicians. A questionnaire was sent to 1,201 randomly selected hospital physicians. The main factors for the decision to report an ADR were the severity of the reaction, a reaction to a new drug, and

This study investigated mental workload in basic civil aviation training. Heart rate, eye movement, and subjective ratings from 11 students were collected during simulator and aircraft sessions. Results show high correspondence in psychophysiological reactions between the sessions. For some flight segments, heart rate was consistently lower in the simulator, suggesting higher mental workload in th