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In this thesis we study functionals of the type \( \mathcal{K}_{f,A,\b}(\x)= \mathcal{Q}(f)(\x) + \|A\x - \b \| ^2 \), where \(A\) is a linear map, \(\b\) a measurements vector and \( \mathcal{Q} \) is a functional transform called \emph{quadratic envelope}; this object is a very close relative of the \emph{Lasry-Lions envelope} and its use is meant to regularize the functionals \(f\). Carlsson an

Although survival has improved in patients with mantle cell lymphoma (MCL) during the last two decades, thanks to intensified approach upfront and with anti-CD20 targeted treatment, the disease is still regarded as incurable and for the elderly/unfit patient population, there is need for more tolerable and effective treatment options. Immunomodulatory drugs (IMiDs) have demonstrated activity in MCAlthough survival has improved in patients with mantle cell lymphoma (MCL) during the last two decades, thanks to intensified approach upfront and with anti-CD20 targeted treatment, the disease is still regarded as incurable and for the elderly/unfit patient population, there is need for more tolerable and effective treatment options. Immunomodulatory drugs (IMiDs) have demonstrated activity in MC

The Worldwide LHC Computing Grid (WLCG) is today comprised of a range of different types of resources such as cloud centers, large and small HPC centers, volunteer computing as well as the traditional grid resources. The Nordic Tier 1 (NT1) is a WLCG computing infrastructure distributed over the Nordic countries. The NT1 deploys the Nordugrid ARC-CE, which is non-intrusive and lightweight, origina

Experimental observations and advanced computer simulations in High Energy Physics (HEP) paved the way for the recent discoveries at the Large Hadron Collider (LHC) at CERN. Currently, Monte Carlo simulations account for a very significant amount of computational resources of the Worldwide LHC Computing Grid (WLCG). The current growth in available computing performance will not be enough to fulfil

Full detector simulation is known to consume a large proportion of computing resources available to the LHC experiments, and reducing time consumed by simulation will allow for more profound physics studies. There are many avenues to exploit, and in this work we investigate those that do not require changes in the GEANT4 simulation suite. In this study, several factors affecting the full GEANT4 si

The increase in the scale of LHC computing during Run 3 and Run 4 (HL-LHC) will certainly require radical changes to the computing models and the data processing of the LHC experiments. The working group established by WLCG and the HEP Software Foundation to investigate all aspects of the cost of computing and how to optimise them has continued producing results and improving our understanding of

Background: We studied the association between cardiorenal function and survival, neurological outcome and trends in survival after in-hospital cardiac arrest (IHCA). Methods: We included cases aged ≥ 18 years in the Swedish Cardiopulmonary Resuscitation Registry during 2008 to 2020. The CKD-EPI equation was used to calculate estimated glomerular filtration rate (eGFR). A history of heart failure

Hereditary cystatin C amyloid angiopathy (HCCAA) is a disorder characterised by multiple strokes in young adults, resulting in paralysis and dementia. The disease is caused by a mutation in the gene coding for the peptidase inhibitor cystatin C. The mutation causes an amino acid substitution Leu68 to Gln in cystatin C (L68Q cystatin C) which results in deposition of the protein in the blood vessel

BackgroundSevere perineal trauma (SPT) affecting the anal sphincter muscle complex is a serious complication following childbirth, associated with short-term and long-term maternal morbidity. Effective preventive strategies are still scarce. The aim of the Oneplus trial was to test the hypothesis that the presence of a second midwife during the second stage of labour, with the purpose of preventin

This article provides an in-depth examination of the U.S. government's role in the case of Raoul Wallenberg, the courageous Swedish envoy who died mysteriously in the Soviet Union after being arrested by Soviet occupation forces at the end of World War II for unknown reasons. The article recounts how U.S. officials, particularly the diplomat Herschel V. Johnson, tried to alleviate the plight of Hu

Objective: To evaluate asynchronous digital visits (eVisits) with regard to digital communication, clinical decisionmaking,and subsequent care utilization in the digital era of primary care in Sweden.Methods: A mixed-methods approach was adopted across the various papers in the thesis, with all studiesevaluating the eVisit platform Flow in various clinical contexts.- Paper I was a comparative stud

We present technology-adjusted consumption-based accounting (TCBA) – a measure of shared responsibility for global greenhouse gas emissions. Unlike in conventional consumption-based accounting (CBA), countries are assigned the emission responsibility for the technology they use to produce their exports. This ensures that national emission responsibilities are not driven by differences in export pr

Hardware implementing spiking neural networks (SNNs) has the potential to provide transformative gains in energy efficiency and throughput for energy-restricted machine-learning tasks. This is enabled by large arrays of memristive synapse devices that can be realized by various emerging memory technologies. But in practice, the performance of such hardware is limited by non-ideal features of the m