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Treatment with alendronate ( Fosamax (R)) has been shown to significantly reduce the risk of fragility fractures. Cost-effectiveness of treatment was assessed in nine European countries in a Markov model and was generally found to be cost effective in women with a previous spine fracture. Introduction Treatment with alendronate (Fosamax (R)) reduces the risk of osteoporotic fractures at the spine,

In Sweden from 1980 to 1995 there was an overall decrease of 56% in mean length of stay (MLOS) for surgical curative breast cancer treatment. The objective of this study was to separate the possible impact of tumour size and lymph node dissemination and changes in surgical procedures. All women diagnosed (n=13 290) with breast cancer between 1982 and 1995 were selected from the Southern Swedish Tu

Objective. In published studies there is a lack of data about the risks, management and how women with autoimmune hepatitis (AIH) decide on and are advised about pregnancy. The aim of this study was to investigate how women with AIH consider pregnancies, are advised and pharmacologically treated, as well as the outcome. Material and methods. A questionnaire was mailed to 128 women with AIH diagnos

Backgound: In severe, medically unresponsive congenital hyperinsulinism (CHI), the histological differentiation of focal versus diffuse disease is vital, since the surgical management is completely different. Genetic analysis may help in the differential diagnosis, as focal CHI is associated with a paternal germline ABCC8 or KCNJ11 mutation and a focal loss of maternal chromosome 11p15, whereas a

Hungary is among the leading countries in Europe regarding the mortality and incidence of different types of tumours. Therefore, developing effective therapies is especially important in this country. Investigation of tumour formation and progression on the molecular level is required to develop possible therapeutical targets. Such targets can be proteins with tumour suppressor function, which inh

The effect of the heat interaction between a water column and sediments on the formation, development, and duration of existence of anaerobic zones in ice-covered lakes is estimated based on observational data from five frozen lakes located in northwestern Russia and North America. A simple one-dimensional model that describes the formation and development of the dissolved oxygen deficit in shallo

The antibody response to the envelope proteins of hepatitis C virus (HCV) may play an important role in controlling the infection. To allow molecular analyses of protective antibodies, we isolated human monoclonal antibodies to the E2 envelope glycoprotein of HCV from a combinatorial Fab library established from bone marrow of a chronically HCV-infected patient. Anti-E2 reactive clones were select

Popular Abstract in Swedish De flesta barn som insjuknar i epilepsi tillfrisknar eller blir anfallsfria med hjälp av antiepileptisk medicin. Hos drygt en fjärde del av barnen blir epilepsin svårbehandlad och anfallskontroll är svår att uppnå. Dessa barn ska i första hand erbjudas möjlighet till epilepsikirurgisk utredning och behandling. När epilepsikirurgisk behandling inte är möjlig att utföra eWhen anti-epileptic drugs fail, and epilepsy surgery is found unfeasible or ineffective, there remains a group of at least 25% of children with epilepsy in whom seizure control cannot be achieved. Vagus nerve stimulation (VNS) is an adjunctive treatment for medically refractory epilepsy. It is an implantable, multi-programmable pulse generator that delivers current electrical stimulation to the va

Popular Abstract in Swedish Variabilitet i ett läkemedels farmakokinetiska (hur ett läkemedel omsätts i kroppen) och farmakodynamiska (vilken effekt ett läkemedel har) egenskaper kan resultera i att olika individer som erhållit samma dos av ett läkemedel får olika effekter av läkemedel. Biverkningar eller utebliven effekt kan innebära allvarliga konsekvenser för den enskilda individen. VariabiliteVariability in pharmacokinetic and pharmacodynamic parameters between individuals can be due to intrinsic and extrinsic factors. In this thesis three different areas regarding sources of variability have been investigated. 1. Formulation properties as an extrinsic source of variability. Lipophilic substances often have poor oral bioavailability and high inter- and intraindividual variability. High

This study assesses the effect of grants given to young Mexican researchers by the International Foundation for Science (IFS) on the development of their academic careers through an analysis of their publication output. Since 1974 IFS has supported similar to 4000 young scientists in developing countries conducting relevant and high quality research on the sustainable use of biological natural res

There are three relativization strategies in the Austroasiatic lang Kammu: (1) deletion of the relativized NP, (2) deletion & change of word order, & (3) pronominalization of the relativized NP. The use of these strategies for the six positions (subject, direct O, indirect O, oblique NP, genitive, & O of comparison) on the relativization hierarchy proposed by E. Keenan & B. Comrie

Popular Abstract in Swedish Avhandlingen är ett teologiskt studium av ett i biblisk litteratur säreget uttryck som angår livets mening: ”att ni skall bli delaktiga av gudomlig natur” (2 Petrus 1:4). Efter en analys av 2 Petrus 1:1-11 undersöks några utvalda texter tillgängliga vid första århundradet som behandlar temat ”att bli delaktiga av gudomlig natur”. Jämförande material utgörs av Gamla testThis book offers a theological study of an expression unique in biblical literature concerning the purpose of life: “that you might become sharers in divine nature” (2 Peter 1:4). Following an analysis of the text-immanent features in 2 Peter 1:1—11, the study delineates comparable notions of “sharers in divine nature” in selected writings that were current in the first century and contrasts these

An automated sample pretreatment of human blood plasma for liquid chromatographic determination of three antidepressant drugs, dibenzepine; a tricyclic antidepressant (TCA), reboxetine; a selective noradrenaline reuptake inhibitor (SNRI) and fluvoxamine; a selective serotonin reuptake inhibitor (SSRI), based on supported liquid membrane (SLM) for unsurpassed sample clean-up and analyte enrichment,

The pseudotetrasaccharide acarbose, previously known as a potent inhibitor of intestinal alpha-glucoside hydrolases, was investigated with regard to its influence on islet lysosomal enzyme activities and the insulin secretory processes. We observed that acarbose was a potent inhibitor of mouse islet lysosomal acid glucan-1,4-alpha-glucosidase activity, EC50 approximately 5 mumol/l, as well as of a