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Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes

Significant progress has been made in elucidating genetic risk factors influencing Type 1 diabetes (T1D); however, features other than genetic variants that initiate and/or accelerate islet autoimmunity that lead to the development of clinical T1D remain largely unknown. We hypothesized that genetic and environmental risk factors can both contribute to T1D through dynamic alterations of molecular

Effect of fiber curvature on gas diffusion layer two-phase dynamics of proton exchange membrane fuel cells

Both straight and curved carbon fibers are widely used in various commercial gas diffusion layer (GDL) fabrications. The effect of the different carbon fiber curvatures on two-phase flow dynamics within the cathode GDLs of proton exchange membrane fuel cells remains unclear. In this study, we investigate liquid transport in three types of GDLs with varying fiber curvatures using the two-phase volu

Proof of Concept : Typesetting of Research in the Academic Publishing Industry

The production, reading and correcting of article proofs is a highly important part of scholarly publishing, and the proof of an article is the only place where researcher, journal production team and publisher come together, directly or indirectly. Yet, the proof process is rarely examined or discussed, and scholars seem to regard it as something separated from the research process. This paper waThe production, reading, and correcting of article proofs is a highly important part of scholarly publishing, and the proof of an article is the only place where researcher, journal production team, and publisher come together, directly or indirectly. Yet, the proof process is rarely examined or discussed, and scholars seem to regard it as something separated from the research process. This paper

Temperature impact on the internal resistance of a PEFC considering the electrochemical impedance spectroscopy

When coupled to different applications, a polymer electrolyte fuel cell (PEFC) work at a different operating temperature. In this study, the internal resistance of a PEFC is evaluated by using Electrochemical Impedance Spectroscopy (EIS) at moderate low current density, i.e., 0.5 A/cm2, in the range of 40 – 80°C. The evaluation is carried out considering frequencies between 10kHz and 0.1Hz. An equ

Reduktionen som erfarenhet : Kris och hoppfullhet i 1680-talets aristokratiska hushåll

Mycket forskarmöda har ägnats åt den stora reduktionen i början av 1680-talet, då den svenska adelns förläningar drogs in till kronan och maktbalansen skiftade till den enväldige kungens fördel. Denna forskning har framför allt behandlat den politiska och ekonomiska utvecklingen, ofta ur ett elitperspektiv. Andra gruppers agerande och levda verklighet har sällan blivit belysta, vilket inte minst gA large body of scholarly work has been dedicated to the Swedish reduction in the early 1680s when fiefs granted to the nobility were revoked as the crown strengthened its position. However, this research has focused on political and economic developments from an elite perspective. Insufficient attention has been paid to the actions and lived realities of other groups, not least the servants of th

Allmogens kultur betraktad genom bomärken – exemplet Väby i Blekinge

Artikeln behandlar hur bomärken brukades av bönder i byn Väby i Bräkne-Hoby socken i Blekinge från 1600-talets slut till 1800-talets första hälft. Dessutom analyseras utvecklingen då bomärkena som underskrifter successivt ersattes med initialer. Först tecknas en översiktlig bild av bomärkenas långa historia och deras roll i den svenska allmogekulturen. Därefter presenteras byn Väby och de förhålla

Institutionalized Dreams : Expectations of Social Advancement in the Swedish Baltic Sea Region, 1680–1770

This study explores the everyday driving forces behind social advancement in the Swedish Baltic Sea region between 1680 and 1770. Characterized by the collapse of the Swedish Empire and increasing bureaucratization, this period presented obstacles to people seeking to improve their status within the prevailing hierarchical order. However, the supplication system consistently channelled social aspi

The role of mathematics in the teaching and learning of physics

This paper discusses the role of mathematics in physics teaching and learning. The intention and strength of science is to describe what happens in the realworld by organizing explanations through theories and theoretical models. It has been widely suggested that learning in science is influenced by views about the nature of scientific knowledge. Furthermore, mathematics is an inherent part of the

The validity of students’ conceptions of differentiability and continuity

University students’ conceptions of differentiability, continuity and relationsbetween these concepts were studied to reveal their choices of representationsand their strategies to justify their relational claims. Questionnaires and interviews were used to collect data. The results were analysed and categorizedthrough a framework based on understanding as connections between concepts,and a theory