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Alzheimer's disease (AD) and age-related cataract, disorders characterized by protein aggregation causing late-onset disease, both involve oxidative stress. We hypothesize that common variants of NFE2L2 and KEAP1, the genes encoding the main regulators of the Nrf2 system, an important defence system against oxidative stress, may influence risk of AD and/or age-related cataract. This case-control s

We study the impact of stochastic mechanisms on a coupled hybrid system consisting of a general advection-diffusion-reaction partial differential equation and a spatially distributed stochastic lattice noise model. The stochastic dynamics include both spin-flip and spin-exchange type interparticle interactions. Furthermore, we consider a new, asymmetric, single exclusion pro- cess, studied elsewhe

A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component o

AIM - This research contributes to highlighting social work assessment of family situations with underage alcohol consumption and abuse. The comparative study invites reflection on the main features influencing an initial approach to adolescent problematic alcohol consumption outside specialised addiction services. DESIGN - The study is based on a cross-national comparison. A questionnaire includi

Lead time, defined as the duration between the moment a request was filed and the moment the decision was made, is an important aspect of decision making in market-driven requirements engineering. Minimizing lead time allows software companies to focus their resources on the most profitable functionality and enables them to remain competitive within the quickly changing software market. Achieving

Accurate policy evaluation is central to optimal policymaking, but difficult to achieve. Most often, analysts have to work with observational data and cannot directly observe the counterfactual of a policy to assess its effect accurately. In this paper, we craft a quasi-experimental design and apply two relatively new methodsthe difference-in-differences estimation and the synthetic controls metho

Abstract Objective. The aim of this study was to strengthen the validity of future findings in the Laparoscopic Prostatectomy Robot Open (LAPPRO) study by investigating the extent of interobserver variability between local pathologists and re-evaluating reference pathologists. Material and methods. LAPPRO is a Swedish prospective study comparing robot-assisted laparoscopic prostatectomy to open re

To assess the differences in upper extremity sensorimotor function, daily hand activities, and perceived participation and life satisfaction between individuals with and without poststroke shoulder pain (PSSP), and to determine how PSSP is associated with these variables.

This paper proposes that the maximum entropy principle can be used for determining the drop size distribution of hydrometeors. The maximum entropy principle can be applied to any physical systems with many degrees of freedom in order to determine a distribution of a variable when the following are known: 1) the restriction variable that leads to a homogeneous distribution without constraint and 2)

Structural dynamics in liquid water slow down dramatically in the supercooled regime. To shed further light on the origin of this super-Arrhenius temperature dependence, we report high-precision (17)O and (2)H NMR relaxation data for H(2)O and D(2)O, respectively, down to 37 K below the equilibrium freezing point. With the aid of molecular dynamics (MD) simulations, we provide a detailed analysis

Interleukin-19 (IL-19) is a putative Th2, anti-inflammatory interleukin. Its expression and potential role in atherogenesis are unknown. IL-19 is not detected in normal artery and is expressed to a greater degree in plaque from symptomatic versus asymptomatic patients, suggesting a compensatory counter-regulatory function. We tested whether IL-19 could reduce atherosclerosis in susceptible mice an

Ongoing global warming not only involves changes in temperature and the global mean; it affects more or less every part of the climate. Regional temperature changes are often greater or smaller than corresponding changes in the global mean. In some cases the direction of change may also be different. For example, temperature changes are higher over land than over the ocean. Precipitation increases

In the absence of early B-cell factor 1 (EBF1), B-cell development is arrested at an uncommitted progenitor stage that exhibits increased lineage potentials. Previously, we investigated the roles of EBF1 and its DNA-binding partner Runx1 by evaluating B lymphopoiesis in single (EBF1(het) and Runx1(het)) and compound haploinsufficent (Ebf1(+/-) Runx1(+/-), ERhet) mice. Here, we demonstrate that dec

To ascertain the epigenomic features, i.e., the methylation, non-coding RNA, and gene expression patterns, associated with gain of i(12p) in Pallister-Killian syndrome (PKS), we investigated single cell clones, harboring either disomy 12 or tetrasomy 12p, from a patient with PKS. The i(12p)-positive cells displayed a characteristic expression and methylation signature. Of all the genes on 12p, 13%

Commentators interested in school-based prevention programs point to the importance of economic issues for the future of prevention efforts. Many of the processes and aims of prevention science are dependent upon prevention resources. Although economic analysis is an essential tool for assessing resource use, the attention given economic analysis within school-based prevention remains cursory. Lar

The outcomes of the Fourth Session of the Global Platform for Disaster Risk Reduction show that making cities and rural areas safe from disasters and climate change impacts and enhancing citizens' resilience is everybody's business and part of the larger sustainability challenge. Under the theme Resilient People, Resilient Planet', the session took place on 19-23 May 2013 in Geneva, Switzerland. T

This discussion highlights and defines key factors and organisational structures for the transformation of local agro-biomass based bioenery systems in Sweden and Denmark. Cross case study analysis is applied to 13 examples where straw is used for energy at various scales within a conceptual framework developed by the authors. This also delivers a cross-country comparison of systems and of the sta