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Current sources of platelets for transfusion are insufficient and associated with risk of alloimmunization and blood-borne infection. These limitations could be addressed by the generation of autologous megakaryocytes (MKs) derived in vitro from somatic cells with the ability to engraft and differentiate in vivo. Here, we show that overexpression of a defined set of six transcription factors effic

Bit-error rate measurements for ON-OFF keying modulation at multigigabit per second rates over a V-band wireless link are presented. Serial data-rates from 2.5 to 20 Gb/s were studied for a 231-1 bit random sequence. Error-free data transfer over a 0.3-m link was achieved at up to 10 Gb/s. Acceptable bit-error rates, <10-5 and 10-3, were measured at up to 1.5 m for 10- and 15-Gb/s data-rate, respe

Migratory songbirds carry an inherited capacity to migrate several thousand kilometers each year crossing continental landmasses and barriers between distant breeding sites and wintering areas. How individual songbirds manage with extreme precision to find their way is still largely unknown. The functional characteristics of biological compasses used by songbird migrants has mainly been investigat

Type 2 diabetes (T2D) is a complex disease with widespread physiological insults to the regulation of metabolic homeostasis, above all glycaemic regulation. The pathogenesis of T2D and its progression is broadly understood to be through a gradual decrease in peripheral insulin sensitivity, a compensatory rise in insulin secretion, and a gradual decline in beta-cell function, resulting in glycaemic

Psoriasis (PSO) and psoriatic arthritis (PsA) are two related chronic inflammatory diseases. A proportion of people with PSO also develop PsA. PSO and PsA seem to have multiple impacts; from the health and well-being of the individual; to the need for healthcare resources for disease management; to the loss of productivity. Compared with other chronic diseases, such as heart disease and diabetes,

A method for optimization of PID controller parameters and measurement filter time constant is presented. The method differs from the traditional approach in that the controller and filter parameters are simultaneously optimized, as opposed to standard, sequential, design. Control performance is maximized through minimization of the integrated absolute error (IAE) caused by a unit step load distur

The genus Bicyclus is one of the largest groups of African butterflies, but due to the generally cryptic nature and seasonal variation of adult wing patterns, there has been a lot of systematic confusion. With a large research community working with the model species Bicyclus anynana there has been increasing interest in the evolutionary history of the genus. A previous phylogeny started to unrave

The surface charging behavior as a function of pH and isoelectric points (IEPs) of single-crystal α-Al2O3 (0001) and (1102) and α-Fe2O3 (0001) was determined by streaming potential measurements using an electrokinetic analyzer. The IEPs of α-Al2O3 (0001) and (11-02)$(1\overline1 02)$ and α-Fe2O3 (0001) were found to be 4.5, 5.1, and 6.5, respectively. These IEP values for oriented single crystals

Antibody-based proteomics offers distinct advantages in the analysis of complex samples for discovery and validation of biomarkers associated with disease. However, its large-scale implementation requires tools and technologies that allow development of suitable antibody or antibody fragments in a high-throughput manner. To address this we designed and constructed two human synthetic antibody frag

The relay autotuner provides a simple way offinding PID controllers of sufficient performance. By usingan asymmetric relay function the excitation of the process isimproved. This gives better models, and hence a better tuning,without increasing the time consumption or complexity of theexperiment. Some processes demand more accurate modelingand tuning to obtain controllers of sufficient performanceThe relay autotuner provides a simple way offinding PID controllers of sufficient performance. By usingan asymmetric relay function the excitation of the process isimproved. This gives better models, and hence a better tuning,without increasing the time consumption or complexity of theexperiment. Some processes demand more accurate modelingand tuning to obtain controllers of sufficient performance