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Background: Growing evidence suggests intergenerational effects of paternal pre-conceptional smoking through the germ line, but its specific impact on offspring semen quality remains uncertain because of challenges in isolating paternal exposure from maternal passive smoking or underreporting. Methods: We reran previous analyses estimating differences in semen parameters and testicular size accord
Som en del av HORIZON EUROPE-projektet AfroSAFE: Säkert system för radikal förbättring av trafiksäkerheten i afrikanska låg- och medelinkomstländer, en översyn av nationella bestämmelser, riktlinjer och procedurer för väginfrastruktursäkerhetshantering (RISM), såväl som vägar. designriktlinjer utfördes i Ghana, Tanzania och Zambia. Information samlades in från relevanta myndigheter och granskningeAs part of the HORIZON EUROPE project AfroSAFE, a review of national regulations, guidelines, and procedures for Road Infrastructure Safety Management (RISM), as well as road design guidelines was carried out in Ghana, Tanzania, and Zambia. Information was collected from relevant authorities and the review had special attention to the safety of vulnerable road users (pedestrians, cyclists, and mot
We compare Holocene tree cover changes in Europe derived from a transient Earth system model simulation (Max Planck Institute Earth System Model - MPI-ESM1.2, including the land surface and dynamic vegetation model JSBACH) with high-spatial-resolution time slice simulations performed in the dynamic vegetation model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator) and pollen-based quantita
Purpose: Linked health-care registries and high coverage in Nordic countries lend themselves well to epidemiologic research. Given its relatively high incidence in Western Europe, complexity in diagnosis, and challenges in registration, multiple myeloma (MM) wasselected to compare registries in Denmark, Finland, and Sweden.Patients and Methods: Data were obtained from four archetypal registries in
Pollinators are important drivers of floral trait evolution, yet plant populations are not always perfectly adapted to their pollinators. Such apparent maladaptation may result from conflicting selection through male and female sexual functions in hermaphrodites. We studied sex-specific mating patterns and phenotypic selection on floral traits in Aconitum gymnandrum. After genotyping 1786 offsprin
Innovation and its management in retail organisations is an emerging field, yet the measurement of innovation in this context remains challenging and under-researched. The study investigates innovation in large Swedish retail companies, focusing on monitoring and measurement of innovation performance. Through a qualitative, multiple case study, our findings reveal that retailers are aiming to beco
The parameters of PMSM with inter-turn fault are identified using a time-stepping finite element method (FEM). Analytical expressions (AE) uses the estimated parameters for fault analysis similar to FEM analysis. The fault waveforms, terminal voltages, obtained from the AE models are used for inter turn fault (ITF) detection, using Stator Flux Linkage DC offset (SFDO). A comparison is made between
Sphingosine-1-phosphate (S1P) is a phosphosphingolipid with pleiotropic biological functions. S1P acts as an intracellular second messenger, as well as extracellular ligand to five G-protein coupled receptors (S1PR1-5). In the brain, S1P regulates neuronal proliferation, apoptosis, synaptic activity and neuroglia activation. Moreover, S1P metabolism alterations have been reported in neurodegenerat
Objective: Cardiovascular disease can be prevented through lifestyle changes, but such changes are often hard to attain. Text message interventions with lifestyle advice have shown small but promising effects. Our objective was to explore participant experience of a text message lifestyle intervention for patients with hypertension, and implications for future lifestyle interventions. Design and s
The effects of NPM have been criticized for decades and we are now seeing how alternative, post-NPM, governance innovations emerge. What joins these innovations is the critique against NPM and the ambition to provide new ways of governing public organizations. From a critical stance, we engage in a discussion of governance innovations from the perspective of social imaginaries and analyse post-NPM
Background: The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy and safety of everolimus and temozolomide as first-line treatment for these patients. Methods: Patients received everolimus 10 mg daily continuously and temozolomide 150 mg/m2 fo
Using renewable fuels is a reliable approach for decarbonization of combustion engines. iso-Butanol and n-butanol are known as longer chain alcohols and have the potential of being used as gasoline substitute or a renewable fraction of gasoline. The combustion behavior of renewable fuels in modern combustion engines and advanced combustion concepts is not well understood yet. Low-temperature combu
Comparison of nestling diet between first and second broods of great tits Parus major in urban and forest habitats. To understand why early broods tend to be more successful than late broods we investigated the nestling diet and reproductive success of great tit pairs that had both a first and a second brood in the same breeding season. We found that in forest habitats great tit parents delivered
Oral assessment is an important method to evaluate the learning outcomes of scientific courses. However,there are certain limitations when oral assessment is applied.One of these limitations, which is not apparent in anonymous written exams, is the existence of biases which could lead to unfair (positive or negative) outcomes of the assessment. This could lead to decreased motivation and sense of
Jerome of Stridon has gone down in the history of Christianity as a fierce defender of what he considered to be orthodox teaching, and, in particular, as a convinced opponent of Origenism. However, this champion of orthodoxy often found himself suspected of relying on heretical writers, and a main purpose of his heresiological efforts was to defend himself against such accusations. The present stu
This article examines the heresiological mechanisms involved in constructing Origenism as a heresy in Late Antiquity. Attention is especially paid to the rhetorical role that “paganism” played in this construction. Focusing on the polemics of Jerome of Stridon, I argue that Jerome created a dichotomy of pagan learning and Christian confession, and described the Origenists as relying excessively on
