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Quantitative bias analyses allow researchers to adjust for uncontrolled confounding, given specification of certain bias parameters. When researchers are concerned about unknown confounders, plausible values for these bias parameters will be difficult to specify. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/09000/The_Importance_of_M…
https://www.lupop.lu.se/article/importance-making-assumptions-bias-analysis - 2025-11-05
The benefits of using data from national registers as endpoints in epidemiological studies include faster, less resource-intensive access to nationwide data and considerably lower loss to follow-up, compared to manual data collection in a limited geographical area. Read the paper at https://www.dovepress.com/validating-acute-myocardial-infarction-diagno…
The integrative data approach is an effective way to conduct cancer research assessing multilevel factors on cancer outcomes among small populations. Read the paper at https://cebp.aacrjournals.org/content/30/8/1506.long
This first publication of the Austrian Society of Esophageal Surgery shows that the outcome of esophageal surgery for cancer in Austria compares well with that of renowned international centers. However, a more comprehensive approach including as many national centers as possible will improve outcome research, offer quality management, and improve patient safety. The study group invites all Austri
https://www.lupop.lu.se/article/esophageal-resection-austria-preparing-national-registry - 2025-11-05
The CARTR Plus registry is a robust resource for ART data in Canada. It provides easily accessible aggregated data for Canadian fertility clinics, and it contains data that are internationally comparable. Read the paper at https://academic.oup.com/hropen/article/2020/3/hoaa022/5848715
https://www.lupop.lu.se/article/cartr-plus-creation-art-registry-canada - 2025-11-05
Parameters representing adjusted treatment effects may be defined marginally or conditionally on covariates. The choice between a marginal or covariate-conditional parameter should be driven by the study question. However, an unappreciated benefit of marginal estimators is a reduction in susceptibility to finite-sample bias relative to the unpenalized maximum likelihood estimator of the covariate-
https://www.lupop.lu.se/article/decreased-susceptibility-marginal-odds-ratios-finite-sample-bias - 2025-11-05
Confounding, selection bias, and measurement error are well-known sources of bias in epidemiologic research. Methods for assessing these biases have their own limitations. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/09000/Multiple_bias_Sensi…
https://www.lupop.lu.se/article/multiple-bias-sensitivity-analysis-using-bounds - 2025-11-05
Monitoring survival in cancer is a common concern for patients, physicians, and public health researchers. The traditional cohort approach for monitoring cancer prognosis has a timeliness problem. In this paper, we propose a survivorship-period-cohort (SPC) model for examining the effects of survivorship, period, and year-of-diagnosis cohort on cancer prognosis and for predicting future trends in
Life-course epidemiology is useful for describing and analyzing complex etiological mechanisms for disease development, but existing statistical methods are essentially confirmatory, because they rely on a priori model specification. Read the paper at https://academic.oup.com/aje/article/190/9/1898/6189737
https://www.lupop.lu.se/article/data-driven-model-building-life-course-epidemiology - 2025-11-05
Although the need for addressing matching in the analysis of matched case-control studies is well established, debate remains as to the most appropriate analytical method when matching on at least 1 continuous factor Read the paper at https://academic.oup.com/aje/article/190/9/1859/6162924
https://www.lupop.lu.se/article/matched-versus-unmatched-analysis-matched-case-control-studies - 2025-11-05
In the causal mediation framework, several parametric-regression–based approaches have been introduced in the last decade for estimating natural direct and indirect effects. For a binary outcome, a number of proposed estimators use a logistic model and rely on specific assumptions or approximations that may be delicate or not easy to verify in practice. Read the paper at https://academic.oup.com/a
Improvements in the treatment of cystic fibrosis (CF) have resulted in longer survival and an increased focus on optimising daily functioning with the condition. Patient- reported outcome measures (PROMs) are valuable tools in evaluating the health- related quality of life of persons with chronic diseases. Read the paper at https://bmjopenrespres.bmj.com/content/bmjresp/8/1/e000927.full.pdf
https://www.lupop.lu.se/article/acceptability-patient-reported-outcome-measures-proms-cystic-fibrosis-data-registry - 2025-11-05
Confounding by comorbidities is of concern in many epidemiological studies. To take this into account a common strategy is to calculate each participant’s Charlson Comorbidity Index (CCI) and use this for adjustment in regression analyses. Various CCI adjustment strategies are possible, and it is unclear, which is preferable. Read the paper at https://link.springer.com/article/10.1007%2Fs10654-021
A key assumption of Mendelian randomization (MR) analysis is that there is no association between the genetic variants used as instruments and the outcome other than through the exposure of interest. One way in which this assumption can be violated is through population stratification, which can introduce confounding of the relationship between the genetic variants and the outcome and so induce an
Investigators performing epidemiological research frequently form hypotheses based on data availability. One might ask how it could be otherwise. After all, what is the point of forming hypotheses if they can’t be tested? Read the paper at https://academic.oup.com/ije/article/50/4/1053/6259481
https://www.lupop.lu.se/article/rounding-usual-suspects-confirmation-bias-epidemiological-research - 2025-11-05
Ny studie från Lunds universitet, Karolinska Institutet och Region Skåne. Läs mer på https://www.lupop.lu.se/battre-beslutsstod-isolering-av-patienter-med-m…
Ny studie från Lunds universitet. Läs mer på https://www.lupop.lu.se/hallbara-utemiljoer
En registerstudie om utvecklingen inom cancerrehabiliteringsområdet samt likheter och skillnader mellan migrerade och svenskfödda kvinnor - en ny studie från Lunds universitet Läs mer på https://www.lupop.lu.se/med-fokus-pa-jamlik-brostcancervard
https://www.lupop.lu.se/article/med-fokus-pa-jamlik-brostcancervard - 2025-11-05
The Swedish Network for Register-Based Research (SWE-REG) is a collaboration between eight research nodes – seven research environments and a graduate school in register-based research. The network strives to use register-based data for research that may benefit people’s health and well-being. Read more, and register at https://swe-reg.se/
https://www.lupop.lu.se/article/swe-reg-autumn-meeting-2021-how-conduct-successful-interdisciplinary-research - 2025-11-05
Project title: Early-life environmental risk factors for inflammatory bowel disease: A Nordic birth cohort study Project: Inflammatory bowel disease (IBD) is a chronic, debilitating immune-mediated disease with a typical onset in childhood and young adulthood. After a rising incidence over the past decades, it now affects 0.5% of Western populations, and is an emerging disease globally. There is a
https://www.lupop.lu.se/article/job-opportunity-doctoral-student-medical-science-environmental-risk-factors-ibd - 2025-11-05
