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Human papillomaviruses (HPV) are established as a major cause of cervical carcinoma. However, causality inference is dependent on prospective evidence showing that exposure predicts risk for future disease. Such evidence is available for squamous cell carcinoma, but not for cervical adenocarcinoma. We followed a population-based cohort of 994,120 women who participated in cytological screening in
The aftermath of breast cancer treatment, especially the sexual side effects, appears to be a neglected issue in developed society. The purpose of this study was to explore how middle-aged women treated for a breast cancer experienced their sexual identity connected to the community norms and values in the society as a whole. Three focus group interviews were conducted, with a total of 12 women. T
Diagnosis of acute mesenteric ischemia in the early stages is now possible with modern computed tomography (CT), using intravenous contrast enhancement and imaging in the arterial and/or portal venous phase. The availability of CT around the clock means that more patients with acute mesenteric ischemia may be treated with urgent intestinal revascularization.
Clotting systems are required in almost all animals to prevent loss of body fluids after injury. Here, we show that despite the risks associated with its systemic activation, clotting is a hitherto little appreciated branch of the immune system. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transglut
This study uses aggregated municipality data, for the years 2001-2009, to explore whether direct payments to farmers affect agricultural employment in Swedish municipalities. The decoupling reform in 2005 included a new grassland support payment accompanied by management obligations that had unexpectedly high redistributive consequences as it greatly increased common agricultural policy payments t
The timing of annual life-history events affects survival and reproduction of all organisms. A changing environment can perturb phenological adaptations and an important question is if populations can evolve fast enough to track the environmental changes. Yet, little is known about selection and evolutionary potential of traits determining the timing of crucial annual events. Migratory species, wh
We have investigated friction between InAs nanowires and three different substrates: SiO2, fluorosilanized SiO2, and Si3N4. The nanowires were pushed laterally with the tip of an atomic force microscope and the friction force per unit length for both static and sliding friction was deduced from the equilibrium shape of the bent wires. On all three substrates, thick wires showed a difference betwee
The growth and morphology of Ag deposited on NiAl(110) and on oxidized NiAl(110) have been investigated by a combination of scanning tunneling microscopy (STM) and high-resolution core-level spectroscopy (HRCLS). While the STM measurements reveal complete wetting and a bilayer growth on clean NiAl(110), Ag nanoparticles with a minimum size of 5 nm were obtained on the oxidized NiAl(110). The diffe
The feasibility of exploiting genomic information for individualized treatment of polygenic diseases remains uncertain. A genetic variant in ADRA2A, which encodes the α2A-adrenergic receptor (α2AAR), was recently associated with type 2 diabetes. This variant causes receptor overexpression and impaired insulin secretion; thus, we hypothesized that blocking α2AAR pharmacologically could improve insu
Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer sus
Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown.
The Selvester QRS scoring system has previously been shown to enable estimation of myocardial infarct (MI) size by quantitative evaluation of the 12-lead ECG. The aim of this study was to assess the system's ability to detect and quantify lateral MI, using cardiac magnetic resonance (CMR) as reference standard.
Laibl, L., Fatka, O., Budil, P., Ahlberg, P., Szabad, M., Voka, V. & Kozak, V., 24.3.2015. The ontogeny of Ellipsocephalus (Trilobita) and systematic position of Ellipsocephalidae. Alcheringa 39, 477-487. ISSN 0311-5518.Well-preserved early holaspid stages of the Cambrian Series 3 trilobites Ellipsocephalus hoffi (Schlotheim, 1823) and Ellipsocephalus polytomus Linnarsson, 1877 have been disco
The origins of allergic asthma, particularly in infancy, remain obscure. Respiratory viral infections and allergen sensitization in early life have been associated with asthma in young children. However, a causal link has not been established. We investigated whether an influenza A infection in early life alters immune responses to house dust mite (HDM) and promotes an asthmatic phenotype later in
The present study reports on the comparison of direct and mediated electron transfer pathways in the interaction of the fungal enzyme cellobiose dehydrogenase (CDH) with the redox protein cytochrome c (cyt c) immobilised at a modified gold electrode surface. Two types of CDHs were chosen for this investigation: a basidiomycete (white rot) CDH from Trametes villosa and a recently discovered ascomyc
Measurements of transverse-single-spin asymmetries (A(N)) in p + p collisions at root s = 62.4 and 200 GeV with the PHENIX detector at the Relativistic Heavy Ion Collider are presented. At midrapidity, A(N) is measured for neutral pion and eta mesons reconstructed from diphoton decay, and, at forward rapidities, neutral pions are measured using both diphotons and electromagnetic clusters. The neut
