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After Tony Blair resigned as the United Kingdom’s prime minster in June 2007, he was appointed as the official envoy of the Quartet on the Middle East. His appointment was marred with controversy not the least with regard to his suitability for the role and his performance as peace envoy, with many observers questioning his ethical credentials. The EU along with the US, Russia and the UN make up t
Localization microscopy methods like Stochastic Optical Reconstruction Microscopy (STORM) are very well suited for exploring clustering of proteins, as the data inherently provide a list of molecular coordinates. Here we use state-of-art cluster analysis algorithms (DBSCAN) to explore the clustering behaviour of different affinity forms of the integrin LFA-1. It has been suggested that LFA-1 may f
Activation of the contact system generates bradykinin from high-molecular-weight kininogen and has been suggested to participate in the pathophysiology of sepsis. To test this, we prospectively measured bradykinin and high-molecular-weight kininogen levels in a cohort of sepsis patients requiring intensive care. From 29 patients meeting criteria for sepsis or septic shock according to Sepsis-3, bl
Stopovers play a crucial role for the success of migrating animals and are key to optimal migration theory. Variation in refuelling rates, stopover duration and departure decisions among individuals has been related to several external factors. The physiological mechanisms shaping stopover ecology are, however, less well understood. Here, we explore how immune function and blood parasite infection
Background: One goal within positive psychiatry is to support the personal recovery of persons with mental illness and providing opportunities for well-being. Aim: The current article aims to introduce readers to the concept of personal recovery and the potential and importance of recovery-oriented services and measures. Methods: A literature review was conducted to help consider the domains of ‘p
Background/Purpose: The aims of this study were to evaluate bowel and urinary tract function, to identify predictors for dysfunctional outcome and to evaluate health-related quality-of life (QoL) in patients treated for sacrococcygeal teratomas (SCT). Methods: Medical records of patients with SCT born between 1985 and 2015 treated at three Swedish pediatric surgical centers were reviewed. Question
Objectives: Inclusion body myositis is characterized by inflammatory and degenerative changes, but the temporal relation of these events is unknown. Materials and Methods: In nineteen patients with inclusion body myositis, muscle strength was correlated with inflammatory and degenerative findings on magnetic resonance imaging (MRI) and in muscle biopsies in three different muscles (tibialis anteri
Gasoline-fueled Partially Premixed Combustion is an advanced combustion concept approaching high efficiency as well as low emissions. The most challenging task on controlling a gasoline PPC engine is to regulate the maximum pressure rise rate to reduce engine noise and durability problem. A trade-off relationship between pressure rise rate and soot emissions is observed as a function of pilot inje
The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. S100A9 is a small molecule which has shown to have a role in the est
Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data (1992–2013) to conduct a population-based, case–control study. C
This paper presents a review of particle deposition research in film-cooled gas turbines based on the recent open literature. Factors affecting deposition capture efficiency and film cooling effectiveness are analyzed. Experimental studies are summarized into two discussions in actual and virtual deposition environments. For investigation in virtual deposition environments, available and reasonabl
Objective: To characterize sociodemographic differences in semen parameters among US men undergoing a semen analysis. Materials and Methods: Men who provided a semen sample were identified from insurance claims between 2007 and 2016. Differences in semen parameters were characterized according to age, race, education, and region. Mean semen parameters and proportions of men with suboptimal paramet
The non-uniform conditions and potential progression of fires in larger spaces calls for modelling methods extending outside of the traditional compartment fire framework. Even though a handful of studies in the area exist there is still little guidance available on how progressing fires in large enclosures can be modelled. Three different methods to calculate far-field gas temperature in large en
Terbinafine is used for the treatment of several superficial fungal infections. In silico analyses and animal models suggest that terbinafine might have an anti-tumor effect. We aimed to explore whether subsequent administration of terbinafine might be associated with a lower mortality rate in patients with prostate cancer. We identified patients diagnosed with prostate cancer between July 2005 an
Turbine blades operate under a harsh environmental condition, and the inlet temperature of gas turbines is increasing with requirement of high engine effi-ciency. Some cooling schemes are adopted to prevent these blades from the ther-mal erosion of the hot mainstream. Film cooling technology is used widely and effectively in gas turbines. The coolant air is suppressed to the wall by the main-strea
Volatile organic compounds (VOCs) in biological samples have gained popularity for disease monitoring and diagnosis. Celiac disease (CD) is one of the many prevalent health conditions which are challenging to diagnose. The aim of this study was to optimize a solid phase microextraction followed by gas chromatography-mass spectrometry, for quantitative analysis of a wide range of VOCs in the urine
Blockchain, the technology underlying bitcoin, is an emerging financial technology (FinTech) that is poised to have strategic impacts on organizations. Because it is a new phenomenon, there are few studies on blockchain, and those studies have focused mainly on the technology's potential impacts, whereas how to effectively implement it in an organization remains unknown. Our study intends to fill
Parliamentary debates provide an arena where Members of Parliament (MPs) present, challenge, or defend public policies. However, the “plenary bottleneck” allows the party leadership to decide who participates in a debate. We argue that in this decision the timing of a debate matters: in proximity of elections, the leadership should be concerned with maintaining its brand name and therefore restric
