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Background: Eukaryotic elongation factor 2 kinase (eukaryotic elongation factor 2 kinase, eEF2K) is a calcium calmodulin dependent protein kinase that keeps the highest energy consuming cellular process of protein synthesis under check through negative regulation. eEF2K pauses global protein synthesis rates at the translational elongation step by phosphorylating its only kown substrate elongation
Sverige och EU har satt upp ambitiösa mål för att minska utsläppen av växthusgaser. Jordbruket står för en stor del av utsläppen och kraftfulla styrmedel behövs. Samtidigt sker handel med jordbruksprodukter på världsmarknaden, vilket innebär att styrmedel som visserligen minskar utsläppen i Sverige och EU också kan leda till att produktion och utsläpp ökar utanför EU – så kallat utsläppsläckage. H
Jordbruket står för en stor del av de globala utsläppen av växthusgaser och ett globalt klimatavtal skulle minska utsläppen.Ett sådant avtal är emellertid svårt att nå. Vi har undersökt hur utsläppen från jordbruket påverkas av en global klimatskatt i olikautformningar och av en klimatskatt som endast införs i EU. Vi finner att:• En global skatt som är lika hög i alla länder ger en relativt stor u
Nitrifikationshämmare (NI) är ett preparat som kan appliceras i samband med gödselspridning. Syftet är att minska risken för kväveläckage och utsläpp av lustgas från jordbruksmark genom att fördröja kvävets omvandling i marken. Denna studie ger en översikt av forskningsläget för NI. Flera studier visar att NI kan ge stora reduktioner av kväveförluster vid rätt förhållanden.Dock finns kunskapslucko
Behavioural Activation (BA) is an established treatment for adults with depression, and research on BA for adolescents is promising. However, there is a knowledge gap in terms of the experiences of adolescents and their parents BA for depression delivered online. Furthermore, there have been no previous studies conducted on the experiences of respondents with regard to the role of the therapist in
Purpose: Consistent assessment of bone metastases is crucial for patient management and clinical trials in prostate cancer (PCa). We aimed to develop a fully automated convolutional neural network (CNN)-based model for calculating PET/CT skeletal tumor burden in patients with PCa. Methods: A total of 168 patients from three centers were divided into training, validation, and test groups. Manual an
Capture into mean motion resonance (MMR) is an important dynamical mechanism because it shapes the final architecture of a planetary system. We simulate systems of two or three planets undergoing migration with varied initial parameters such as planetary mass and disk surface density and analyse the resulting resonant chains. In contrast to previous studies, our results show that the disk properti
Denna rapport har sammanställts på uppdrag av Region Skånes kulturförvaltning under perioden mars – september 2022. Kartläggningsuppdraget är en del i Region Skånes arbete med att stärka samverkan mellan kultur- och utbildningssektorn inom utvecklingsområdet konstnärligt skapande. Syftet med rapporten är att ge en både övergripande och detaljerad bild av befintlig utbildningsinfrastruktur i Skåne,
In this study, two methods for wastewater treatment plant (WWTP) dimensioning were compared: (1) a traditional guideline-based approach, and (2) a mechanistic model-based approach. The design outputs depended on uncertainties in correlated influent concentrations, which emphasises the importance of uncertainty analysis. The results showed that model-based design could simplify and reduce the time
PurposeThis study aims to examine the role of service customers’ variety-seeking and engagement in driving their service switching intention. The authors also explore the moderating role of customer relationship proneness in this association.Design/methodology/approachTo test the hypotheses, the authors deployed a sample of 227 service customers, whose data was analyzed by using partial least squa
While consumer engagement and value cocreation research proliferate, it is important to explore these concepts from an ecosystem-based multi-stakeholder perspective as, therefore, undertaken in this article. Specifically, this study marks a pioneering attempt in conceptualizing stakeholder engagement (SE) as a core foundation of stakeholder value cocreation within multi-stakeholder service ecosyst
Purpose: Contemporary firms are increasingly focusing on enhancing the customer experience (CX) to gain a sustainable competitive advantage. However, despite the rapid growth of CX research from both the customer's and the firm's perspectives, the intellectual structure of CX research remains tenuous, thus requiring further investigation. Addressing this gap, the authors review and map the existin
Though the customer journey (CJ) is gaining traction, its limited customer focus overlooks the dynamics characterizing other stakeholders’ (e.g., employees’/suppliers’) journeys, thus calling for an extension to the stakeholder journey (SJ). Addressing this gap, we advance the SJ, which covers any stakeholder’s journey with the firm. We argue that firms’ consideration of the SJ, defined as a stake
Background: The ProtonCare Study Group (PCSG) was formed with the purpose to develop and implement a framework for evaluation of proton beam therapy (PBT) and the related care at a novel clinic (Skandionkliniken), based on patient reported data. Method: A logic model framework was used to describe the process of development and implementation of a structured plan for evaluation of PBT for all diag
Background: The aim was to review available biokinetic data, collect own experimental data, and propose an updated compartmental model for 2-[18F]FDG in the frame of the revision of the ICRP report on dose coefficients for radiopharmaceuticals used in diagnostic nuclear medicine. Methods: The compartmental model was developed based on published biokinetic data for 2-[18F]FDG. Additional data on ur
PURPOSE: Women with current or previous drug use are at risk of poor breast and cervical cancer outcomes. While screening is known to decrease cancer mortality, screening participation is sparsely investigated among drug dependent women. The aim of this study was to explore experiences of breast and cervical cancer screening-including barriers and suggested interventions to promote increased parti
Background: Direct-to-consumer telemedicine (TM), with patients having access to a physician via video or text chat, has gradually been introduced into Swedish primary care during the last two decades. Earlier studies have concluded that patients were generally satisfied with TM and the satisfaction rate was consistently above 80% and comparable with in-person visits. Despite the number of studies
Background: Individual motor units have been imaged using ultrafast ultrasound based on separating ultrasound images into motor unit twitches (unfused tetanus) evoked by the motoneuronal spike train. Currently, the spike train is estimated from the unfused tetanic signal using a Haar wavelet method (HWM). Although this ultrasound technique has great potential to provide comprehensive access to the
