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Mantle cell lymphoma (MCL) is a rare, aggressive, incurable B-cell malignancy. Ibrutinib has been shown to be highly active for patients with relapsed/refractory (R/R) MCL. The RAY trial (MCL3001) was a phase 3, randomized, open-label, multicenter study that compared ibrutinib with temsirolimus in patients with R/R MCL. Active disease is frequently associated with impaired functional status and re

Software engineers working in large projects must navigate complex information landscapes. Change Impact Analysis (CIA) is a task that relies on engineers' successful information seeking in databases storing, e.g., source code, requirements, design descriptions, and test case specifications. Several previous approaches to support information seeking are task-specific, thus understanding engineers'

Background. Search and selection of primary studies in Systematic Literature Reviews (SLR) is labour intensive, and hard to replicate and update. Aims. We explore a machine learning approach to support semi-automated search and selection in SLRs to address these weaknesses. Method. We 1) train a classi er on an initial set of papers, 2) extend this set of papers by automated search and snowballing

Background: The causes and effects of anastomotic leakage after anterior resection are difficult to study in small samples and have thus been evaluated using large population-based national registries. To assess the accuracy of such research, registries should be validated continuously. Material and methods: Patients who underwent anterior resection for rectal cancer during 2007–2013 in 15 differe

Objective: Ovarian clear cell carcinomas (OCCCs) constitute a rare ovarian cancer subtype with distinct clinical features, but may nonetheless be difficult to distinguish morphologically from other subtypes. There is limited knowledge of genetic events driving OCCC tumorigenesis beyond ARID1A, which is reportedly mutated in 30-50% of OCCCs. We aimed to further characterize OCCCs by combined global

Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children with the DR4-DQ8 haplotype, exogenous factors, yet to be identified, are thought to trigger an autoimmune reaction against insulin, signalled by insulin autoantibodies as the first autoantibody to appear. In child

Purpose: Nationwide data have been lacking on drug abuse (DA)-associated mortality. We do not know the degree to which this excess mortality results from the characteristics of drug-abusing individuals or from the effects of DA itself. Method: DA was assessed from medical, criminal, and prescribed drug registries. Relative pairs discordant for DA were obtained from the Multi-Generation and Twin Re

The aim is to explore the absence or presence of, and motives for, research at centers for academic development and to problematize the research situation among academic developers. Boyer’s and Healey’s theories are used as lenses for the analysis based on the questionnaires that were used for data collection. The conclusion is that research is a challenging and sensitive area for university cente

This study investigated the perceptions of the young citizens of Macau about volunteerism, and how this perception affected volunteer reruitment and retention, and the market strategies of the non-profits. The study covered implicitly the question of competition and substitution of volutneerism as perceived by the young people in Macau; how the non-profits competed with each other in recruiting vo

In this multidisciplinary project lime-hemp is studied as a thermal insulating material for the renovation of historic timber and brick buildings*). Focus is on buildings in the historic city of Visby on the Swedish island of Gotland in the Baltic sea. Many historic buildings in Visby have over the past decades been thermally insulated with materials such as mineral wools and polystyrene. Due to t