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Aims: CT acquisition parameters and reconstruction techniques may affect the accuracy of calcium scoring measurements with a potential impact on clinical decision making. We evaluated the agreement of half- versus standard-dose protocols for assessment of aortic valve (AVCS HD and AVCS SD protocols) and coronary artery calcium scoring (CACS HD and CACS SD protocols) with and without the applicatio

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Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100–104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan,

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The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung transplantation requires nuanced planning and execution by an integrated team of multidisciplinary experts. To date, no multidisciplinary consensus document has examined the perioperative considerations of how to best manage these patients. To address this challenge, this perioperative utilization of ECLS in l

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Can the way a word is used give legitimacy to a political movement? Feminism, Violence, and Representation in Modern Italy traces the use of the word "femminicidio" (or "femicide") as a tool to mobilize Italian feminists, particularly the Union of Women in Italy (UDI). Based on nearly two years of fieldwork among feminist activists, Giovanna Parmigiani takes a broad look at the many ways in which

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Based on an ethnographic research among contemporary Pagan communities in Southern Italy (Salento, Apulia), The Spider Dance challenges ideas of historicity, healing, place-making and the experience of time among persons engaged in reviving, continuing, or re-creating traditional Pagan practices. The Spider Dance looks at a specific Pagan group, the sisters of the cerchio (circle), and their ritua

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The concept of early vascular aging (EVA) was introduced to identify adults at risk of developing premature cardiovascular disease. EVA, or the dissociation between chronologic and biologic age of large arteries, is an evolving concept. In this review, we propose that EVA in youth characterizes the early life biological and environmental risk factors that precede overt EVA. During early infancy, c

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Time-frequency decomposition is a well-established method to unmix signals generated by multiple sources with unique characteristics. However, there are cases of high signal complexity where existing time-frequency decomposition tools are insufficient for localizing and representing short-bursting signals. One example is the currently highly popular extracellular low-impedance recordings from mult

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System co-sensitization and extension of the π-conjugated system are recognized as two key strategies for improving the performance of dye-sensitized solar cells (DSSCs). In this study, density functional theory (DFT) was employed to simulate two experimentally synthesized molecules, RK1 and D205, and to evaluate the performance of their co-sensitization system. Furthermore, molecular design was c

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Altermagnets are a class of magnetic materials that exhibit unconventional transport properties, such as an anomalous Hall effect (AHE), despite having compensated sublattice magnetic moments. In this study, fundamental experimental evidence of the altermagnetic nature of hematite (α-Fe2O3), is reported combining electrical transport with advanced X-ray photoemission electron microscopy (XPEEM) im

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Fencing to exclude livestock is one of the effective strategies to passively reshape grassland ecosystem function, yet the dynamics of microbial community construction and their functional traits during restoration remain poorly understood. This study systematically sampled from various microhabitats (phyllosphere, litter, soil) within long-term fenced restoration areas, as well as areas with pers

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The expansion of the electric vehicle industry is driving increased demand for lithium-ion batteries (LIBs), which in turn creates challenges in material availability and waste management that more durable LIBs could address. Electrode surface coating helps extend LIB lifespan, with atomic layered deposition (ALD) as the preferred method due to its precise thickness control and ability to coat var

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Organic pollutants in aquatic environments pose a threat to ecosystems and human health, a challenge that requires urgent resolution. This urgent threat highlights the need for the development of efficient technologies for pollutant detection and degradation in environmental protection. This study presents the successful fabrication of a composite nanomaterial consisting of Ag nanoparticle-decorat

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Product development faces increasing challenges in today’s fast-evolving environment. Agile has emerged as a promising approach to navigate and succeed under such conditions. Grounded in the values and principles of the Manifesto for Agile Software Development, practitioners have designed agile frameworks and practices that have demonstrated significant benefits in software development. Motivated

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Background Irritable bowel syndrome (IBS) is the most common disorder of gut-brain interaction and associated with overweight. Low content of fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) and a starch- and sucrose-reduced diet (SSRD) alleviate IBS symptoms, but restrictive diets may lead to malnutrition. The aim of the present clinical trial was to randomize IBS patients to eit

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The classical best-subset selection method has been demonstrated to be nondeterministic polynomial-time-hard and thus presents computational challenges. This problem can now be solved via advanced mixed integer optimization (MIO) algorithms for linear regression. We extend this methodology to linear instrumental variable (IV) regression and propose the best-subset instrumental variable (BSIV) meth

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The establishment of innovation ecosystems has become an increasingly prevalent strategy for fostering territorial, economic and social development. However, the existing literature provides limited insights into the strategic conditions that enable the emergence of such ecosystems. This paper addresses this gap by identifying the critical elements and mechanisms underpinning their creation. Speci