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Objective. Primary aldosteronism (PA) is the most common form of secondary hypertension. Thus, the aims of this study were: (1) to clarify whether the fludrocortisone suppression test (FST), which confirms autonomous aldosterone secretion, is reliable when carried out during a shorter period of time and (2) to confirm the importance of NaCl supplementation. The cut-off limits already obtained for

Thymidine kinase 2 (TK2) deficiency in humans causes mitochondrial DNA (mtDNA) depletion syndrome. To study the molecular mechanisms underlying the disease and search for treatment options, we previously generated and described a TK2 deficient mouse strain (TK2(-/-)) that progressively loses its mtDNA. The TK2(-/-) mouse model displays symptoms similar to humans harboring TK2 deficient infantile f

In this work, spectroscopic techniques and quantum chemistry calculations were used to investigate the photophysical properties of 2-ureido-4[1H]-pyrimidinone (UPy) systems in two different solvents of DMSO and DCM. The investigations were carried out on the three UPy systems (AnUP, NaUP and UPNa) with two different choromophores (i.e., anthracene and naphthalene) located at the head and the tail

In this work, we provide a detailed microscopic picture of the behavior of benzoic acid at the aqueous solution/vapor interface in its neutral as well as in its dissociated form (benzoate). This is achieved through a combination of highly surface-sensitive X-ray photoelectron spectroscopy experiments and fully atomistic molecular simulations. We show that significant changes occur in the interface

Objective To assess the degree of confidence with which expert ultrasound operators make a diagnosis of benign, borderline and invasive malignant ovarian tumors and its effect on diagnostic accuracy and interobserver agreement. Method Digitally stored static two-dimensional B-mode images of representative cases of benign, borderline and invasive malignant ovarian tumors were independently assessed

Perlecan is a heparan sulfate proteoglycan assembled into the vascular basement membranes (BMs) during vasculogenesis. In the present study we have investigated vessel formation in mice, teratomas and embryoid bodies (EBs) in the absence of perlecan. We found that perlecan was dispensable for blood vessel formation and maturation until embryonic day (E) 12.5. At later stages of development 40% of

Language is context free in the sense that it builds well-formed structures like "ideas sleep" and "ghosts live" (NP + VP) without regard to meaning and specific contexts (Chomslcy, 1957). However, it is also context sensitive in the sense that it makes use of linguistic objects such as personal pronouns and other indexical expressions that cannot have any reference unless they are embedded in som

This review article focuses on advances and technical developments of the realm of membrane extraction techniques for the analytes that are (made) amenable to gas chromatographic analysis, and sheds light on the analytical applications to biological and environmental samples. In this review, the state of the art in this growing area of membrane extraction for gas chromatography is presented and se

Akt (also known as PKB) is a survival kinase frequently up-regulated in cancer; three isoforms of Akt exist, and among them Akt1 and Akt2 are the most widely and highly expressed. They share the same structure and activation mechanism and have many overlapping functions; nevertheless isoform-specific roles and substrates have been reported, which are expected to rely on sequence diversities. In pa

New basis sets of the atomic natural orbital (ANO) type have been developed for the lanthanide atoms La-Lu. The ANOs have been obtained from the average density matrix of the ground and lowest excited states of the atom, the positive ions, and the atom in an electric field. Scalar relativistic effects are included through the use of a Douglas-Kroll-Hess Hamiltonian. Multiconfigurational wave funct

OBJECTIVE-To determine the relative risk associated with DPA1 and DPB1 alleles and haplotypes in type I diabetes. RESEARCH DESIGN AND METHODS-The frequency of DPA1 and DPB1 alleles and haplotypes in type I diabetic patients was compared to the family based control frequency in 1,771 families directly and conditional on FILA (B)-DRB1-DQA1-DQB1 linkage disequilibrium. A relative predispositional ana

Vartannat år har Nordisk Lichenologisk Förening exkursion till något av medlemsländerna. I år gick exkursionen till Litauen och här får vi en rapport av Arne Thell.

In this paper the question of returns to scale in scientific production is analysed using non-parametric techniques of multidimensional efficiency measurement. Based on survey data for German research groups from three scientific fields, it is shown that the multidimensional production possibility sets are weakly non-convex and locally strictly non-convex. This suggests that the production functio

The Lamperti transformation of a self-similar process is a stationary process. In particular, the fractional Brownian motion transforms to the second order stationary Gaussian process. This process is represented as a series of independent processes. The terms of this series are Ornstein-Uhlenbeck processes if H < 1/2, and linear combinations of two dependent Ornstein-Uhlenbeck processes whose two

Caterpillars of the mining micro-moth Phyllocnistis labyrinthella feed on leaves of aspen (Populus tremula) and are often parasitized by eulophid wasps. The parasitoids are a potential important cause of death for the miners. During 2009-2011 we collected mined leaves from an experimental stand of aspen trees in Västerbotten. Adults emerged from 17-35 percent of the mines and of these every second

Hoverflies are important pollinators, but constitute a less studied group of insects. In this study we collected hoverflies in most open grasslands and woodlands in an area of 5000 hectares over six years (2004-2009) in the central part of the parish of Stenbrohult, southern Sweden (Fig. 1; 56o 37´ N, 14o 11´ E). The studied area is dominated by spruce forests, but deciduous forests are relatively

Clostridium difficile infection (CDI) is gradually being recognised as a cause of morbidity in the community. We investigated the incidence and clinical characteristics of CDI in a community setting and characterised the C. difficile strains by toxin gene profiling and polymerase chain reaction (PCR) ribotyping. Patients included in the study had attended general practice, primarily because of dia