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Pulmonary arterial hypertension (PAH) is a life-threatening condition with no cure, making research into its underlying mechanisms critical. The platelet-derived growth factor (PDGF) signaling pathway plays a crucial role in vascular remodeling, a key factor in PAH progression. Anti-PDGF receptor therapies, such as imatinib, show promise but are associated with significant side effects. Recent res
A review on Archaeologist Peter Carelli's study about chess and chess pieces found in Scandinavia during the Middle ages.
The historical archaeology of early modern churches andchapels in northern Sweden in general and in Norrbotten inparticular is an understudied field of research. The purposeof this paper is to survey the breadth and variation of thechurches and chapels of the Norrbotten region from the latemedieval period to the eighteenth century, with focus on theseventeenth century. In particular the church at
Volatile organic compounds (VOCs) include many types of organic compounds, such as alkanes, olefins, aldehydes, etc. They have attracted widespread attention in various fields such as food and flavor analysis, environmental and atmospheric research, safety, or healthcare. Developing efficient, practical, and high-value industrial VOC utilization technologies is crucial for sustainable social and h
Aims and Objectives/Purpose/Research Questions:Our paper outlines the development of vocabulary proficiency tests for minority languages and addresses the challenges in doing so.Design/Methodology/Approach:The strategies are exemplified based on recently developed tests for Sicilian and Venetan, two large languages in Italy without official status. Users of these types of languages tend to have on
The selective oxidation of alcohols to corresponding carbonyl compounds is essential in academia and industry. Benzil and BHMF have emerged as important classes of carbonyl compounds that have shown promising applications in materials and drug intermediates, especially in sustainable bio-based plastics. The traditional selective oxidation process generally uses equivalent amounts of oxidants or to
The introduction discusses the concepts of dynasty and state formation and their interrelated nature. It stresses the need to define the concept of dynasty as a kinship group with an acute sense of historical continuity, claiming the right to rule a certain territory and manifesting this claim in political, social and cultural ways; and the related concept of dynasty formation as the acts, conscio
Among the more than 2,000 interments from the Phaleron Burial Ground, 79 individuals buried in the Esplanada mass graves are said to have died violently, perhaps bludgeoned to death. The Esplanada remains were observed in the field by Ingvarsson and Bäckström (2019); ten of these 79 were later excavated and studied by Buikstra and colleagues in a laboratory setting. The field and laboratory analysAmong the more than 2,000 interments from the Phaleron Burial Ground, 79 individuals buried in the Esplanada mass graves are said to have died violently, perhaps bludgeoned to death. The Esplanada remains were observed in the field by Ingvarsson and Bäckström (2019); ten of these 79 were later excavated and studied by Buikstra and colleagues in a laboratory setting. The field and laboratory analys
TiSe2 has long been considered one of the best candidate materials to host the elusive excitonic insulator (EI) phase. However, a finite coupling to the lattice can generically be expected, while a lack of "smoking-gun"signatures for the importance of the electron-hole interaction in driving the phase transition has rendered it challenging to distinguish the EI from the conventional charge-density
The rheology of dense granular shear flows is influenced by friction and particle shape. We investigate numerically the impact of nonspherical particle geometries under shear on packing fraction, stress ratios, velocity fluctuations, force distribution, and dissipation mechanisms, for a wide range of inertial numbers, friction coefficients and aspect ratios. We obtain a regime diagram for the diss
The p53 gene product is a tumour suppressor protein, and alterations of the protein are common in human cancer. Previous studies have focused on nuclear accumulation of p53. To investigate if cytoplasmic accumulation of p53 strengthens the relationships to different pathobiological variables and distant recurrence-free survival in breast cancer, tumours from 164 stage II patients were examined wit
Övergången till en hållbar textilindustri, såsom textilåtervinning, kräver förbättrade metoder för hantering av färgämnen. För närvarande finns inga generella, industriellt implementerade processer som avlägsnar färgämnen utan att skada dem, och examensarbetet undersöker detta tillsammans med Rewin Textiles AB. Företaget återvinner polyester genom depolymerisering och därför utvärderas implementerThe transition towards sustainable textile approaches, such as textile recycling, requires im-proved methods for handling dyes. Currently, no real industrially implemented processes exist that remove dyes without damaging them and this thesis investigates this issue together with Rewin Textiles AB. This company recycles polyester through depolymerisation and therefore, the implementation of a pre-
Uppsatsen behandlar lagstiftningsprocessen bakom införandet av den nya bestämmelsen i 24 kap 19 a § IL, som utgör en del av de riktade ränteav-dragsbegränsningsreglerna. Syftet är att analysera vilka intressen som har haft störst genomslag vid utformningen av bestämmelsen samt att bedöma om den nya regeln är förenlig med EU-rätten, särskilt mot etableringsfriheten och EU-domstolens praxis gällandeThis thesis examines the legislative process behind the introduction of the new provision in Chapter 24, Section 19 a of the Swedish Income Tax Act, which forms part of the targeted interest deduction limitation rules. The aim of the study is to analyse which interests have had the greatest influence on the de-sign of the provision and to assess whether the new rule is compatible with EU law, in p
Nästan hela Sveriges befolkning bor i städer, varav många är byggda utifrån tidigare klimatförhållanden där extrema skyfall, stigande havsnivåer och jordskred inte var lika vanligt förekommande som i dag. Detta kan leda till översvämmade bostäder, förstörda vägar och utslagen infrastruktur. För att vi ska kunna fortsätta leva i våra städer måste bebyggelsen anpassas till dagens och morgondagens klClimate change, manifested through flooding, landslides, and erosion, poses increasing challenges for the built environment. In Sweden, nearly 90 percent of the population resides in urban areas, which were planned under past climatic conditions and are often difficult to adapt retroactively. Spatial planning plays a crucial role in addressing this issue, with municipalities holding central respo
The thesis aims to understand if the use of a structured data mining process has an impact on rationality or intuition in decision making. To operationalize this purpose, a questionnaire was sent to 655 data analysts and data scientists working in diverse organizations through the professional social network LinkedIn. The questionnaire was based on the theoretical background, consisting of decisio
Att samarbeta kring klimatanpassning – vad kan vi lära av ett policylabb? Hur ska vi egentligen samarbeta kring klimatförändringar, när människor har olika ansvar, intressen och makt över mark och resurser? I denna studie har policylabb Storkriket stått i centrum, med syfte att undersöka i vilken utsträckning policylabb kan stödja klimatarbetet och frågor om samverkan. Resultaten visar att deTo reduce vulnerability and enhance resilience to climate change, climate adaptation measures are needed that can contribute to a more resilient society. Cross-sectoral collaboration and the involvement of multiple actors are central to a coherent and comprehensive approach to climate adaptation. The aim of this study is to contribute to an increased understanding of how policy labs can be used a
Hur många roller ska skogen ta sig an? Skogen kan ta an många olika roller. Den kan vara en vacker vandringsmiljö. Kanske ett förvaringsutrymme för koldioxid? Eller till och med en viktig källa för bioenergi. Skogens förmåga att bidra med flera funktioner är fantastiskt men precis som andra naturresurser är förrådet begränsad. Dessutom är skogen en central del i klimatarbetet där dess funktion soThe land use, land-use change, and forestry sector (LULUCF) has historically been rather unregulated. Recent political developments have put pressure on countries to implement practices that increase net greenhouse gas (GHG) removals and improve the state of carbon sinks. One of these political developments is the European Union’s (EU) LULUCF Regulation, which as of now obligates Member States (MS
This thesis aims to strengthen the scientific basis for forensic assessments of single stab injuries to the trunk, which have traditionally been based upon professional experience rather than scientifically evaluated evidence. Using nationwide registries maintained by the Swedish National Board of Forensic Medicine, we conducted five studies including both fatalities and survivors of sharp force t
Det vaga begreppet barnets bästa är beroende av samhällets utveckling och hur vi ser på barn – ibland fortfarande som ägodelar. Detta är fortfarande särskilt framträdande i den sociala barnlagstiftningen.The nebolous concept of the best interests of the child is dependent of the development of society and how we view children - sometimes still as possessions. This is still particularly prominent in social children's welfare legislation.
The use of artificial intelligence in law represents one of the biggest challengesacross different legal systems. Supporters of predictive systems believe thatdecisionmaking could be more efficient, consistent and predictable by usingAI. European legislation and legal scholars, however, identify areas where AIdevelopments are at high risk or too dangerous to be used in judicial proceedings.In thisThe use of artificial intelligence in law represents one of the biggest challenges across different legal systems. Supporters of predictive systems believe that decisionmaking could be more efficient, consistent and predictable by using AI. European legislation and legal scholars, however, identify areas where AI developments are at high risk or too dangerous to be used in judicial proceedings. In
