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The ability to store and mobilize energy is fundamental for physiologic function. Most excess energy is stored in adipose tissue as triglycerides, which is released as free fatty acids when needed through cellular processes tightly regulated by insulin. Intact adipose cell function is essential to regulate whole-body glucose and lipid metabolism. Several studies have focused on the metabolic impac
This study investigates machining superalloy Inconel 718 with polycrystalline cubic boron nitride (pcBN) tooling both numerically and experimentally. Particular attention is given to mechanical and thermal stresses in the cutting tool arising from segmented chip formation and associated forces and temperatures. The temperature dependence of the mechanical properties of pcBN has been investigated a
This paper discusses the importance of learning to understand the three-dimensionality of astronomical objects, in particular nebulae. After collecting data from students' and professors' discernment of 3D we finds that this is difficult for both students and professors, which highlights the importance of addressing extrapolating three-dimensionality in astronomy education.
In a material of 942 patients with malignant hematological disease, encompassing all diagnosed cases in the county of Jämtland in Sweden during a 22‐yr period, 36 families with multiple cases of such disease were found. Approximately 5% of the patients have at least one close relative who also suffers from a malignant hematological disease. An especially strong familial occurrence was found in the
A case‐referent study on soft tissue sarcomas (STS) was conducted, to see if previous findings regarding an association between exposure to phenoxyacetic acids or chlorophenols and this tumor type could be reproduced. Fifty‐five male STS patients were thereby compared with 220 living and 110 dead population‐based referents. Furthermore, another referent group consisting of 190 patients with anothe
Checkpoint blockade therapies have changed the clinical management of metastatic melanoma patients considerably, showing survival benefits. Despite the clinical success, not all patients respond to treatment or they develop resistance. Although there are several treatment predictive biomarkers, understanding therapy resistance and the mechanisms of tumor immune evasion is crucial to increase the f
The rapid development of new therapies in metastatic breast cancer (MBC), entails a need for improved prognostic and monitoring tools. Thymidine kinase 1 (TK1) is involved in DNA synthesis and its activity correlates to outcome in cancer patients. The aim of this study was to evaluate serum TK1 activity (sTK1) levels in MBC patients as a tool for prognostication and treatment monitoring. 142 women
In a case-control study including 237 cases with soft tissue sarcoma and 237 controls, previous jobs and exposures to different agents, including pesticides, were assessed. Exposure to phenoxyacetic acids or chlorophenols gave a statistically significant increased rate ratio (RR) of 1.80 [95% confidence interval (CI) = 1.02-3.18] for soft tissue sarcoma. Exposure to phenoxyacetic acids of all type
Vascular bio-scaffolds produced from decellularized tissue offer a promising material for treatment of several types of cardiovascular diseases. These materials have the potential to maintain the functional properties of the extracellular matrix (ECM), and allow for growth and remodeling in vivo. The most commonly used methods for decellularization are based on chemicals and enzymes combinations,
