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Lung transplantation is the only option for end-stage lung diseases, but organ shortage remains problematic. Generating lungs ex vivo could overcome shortages with current approaches being explored for lung tissue engineering utilizing a biologically derived, synthetic or hybrid scaffold which is seeded with cells and cultured ex vivo. Ideally, cells could be sourced from the transplant recipient
Introduction: The extent to which pain is distributed across the body (spreading of pain) differs largely among patients with chronic pain conditions and widespread pain has been linked to poor quality of life and work disability. A longer duration of pain is expected to be associated with more widespread pain, but studies are surprisingly scarce. Whether spreading of pain is associated with clini
The pathological hallmark of Parkinson’s disease (PD) is the formation of Lewy bodies containing aggregated alpha-synuclein (α-syn). Although PD is associated with these distinct histological changes, other pathological features such as microvascular alterations have been linked to neurodegeneration. These changes need to be investigated as they create a hostile brain microenvironment and may cont
Ptychographic X-ray microscopy is an ideal tool to observe chemical processes under in situ conditions. Chemical reactors, however, are often thicker than the depth of field, limiting the lateral spatial resolution in projection images. To overcome this limit and reach higher lateral spatial resolution, wave propagation within the sample environment has to be taken into account. Here, we demonstra
Sliding mode control (SMC) is to keep the system to a stable differential manifold. Model predictive control (MPC) calculates the control input by solving an optimization problem on receding horizon. The method of receding horizon sliding control (RHSC) includes the predicted information into the SMC design by combining SMC and MPC. Considering the modeling error and measurement noise, there are m
In order to mitigate global warming, it is important to decrease the climate impact from the building stock, which accounts for 39% of the GHG emissions in Europe. An extensive portion of these emissions are generated from the heating of buildings, but emissions also occur from the production of building materials. It is therefore important to find building design solutions that consider both prod
Some foreign policy analysts believe that what we are witnessing in the 21st century is nothing short of a reconfiguring of the global political order - with China firmly positioned at the helm as a (re)emerging great power. At present, the notion of the imminent establishment of a ‘new world order with Chinese characteristics’ is increasingly gaining traction. This sentiment has long permeated fo
Little is known about the impacts of persistent triazine herbicides and biocides on soil microorganisms. Terbutryn toxicity in soil microorganisms was studied using bacterial and fungal growth, substrate induced respiration (SIR) and basal respiration as ecotoxicological end-points. In the short-term (0–7 days), increasing concentrations of terbutryn (0–800 mg kg−1) progressively inhibited bacteri
The elliptic and triangular flow coefficients v2 and v3 of prompt D0, D+, and D⁎+ mesons were measured at midrapidity (|y|<0.8) in Pb–Pb collisions at the centre-of-mass energy per nucleon pair of sNN=5.02TeV with the ALICE detector at the LHC. The D mesons were reconstructed via their hadronic decays in the transverse momentum interval 1
BACKGROUND: Blood loss and adult blood transfusions are common during the neonatal period in preterm infants. The objective of the study was to clarify if degree of loss of fetal haemoglobin (HbF) was associated with later retinopathy of prematurity (ROP).METHODS: Retrospective observational cohort study. In total, 452 infants born <30 gestational weeks at a tertiary level neonatal intensive care
Importance: Lack of arachidonic acid (AA) and docosahexaenoic acid (DHA) after extremely preterm birth may contribute to preterm morbidity, including retinopathy of prematurity (ROP).Objective: To determine whether enteral supplementation with fatty acids from birth to 40 weeks' postmenstrual age reduces ROP in extremely preterm infants.Design, Setting, and Participants: The Mega Donna Mega trial,
The recently documented high survival of extremely preterm infants in Sweden is related to a high degree of centralization of pre- and postnatal care and to recently issued national consensus guidelines providing recommendations for perinatal care at 22-24 gestational weeks. The prevalence of major neonatal morbidity remains high and exceeded 60 % in a recent study of extremely preterm infants bor
BACKGROUND: Germinal matrix-intraventricular haemorrhage (GMH-IVH) remains a substantial issue in neonatal intensive care units worldwide. Current therapies to prevent or treat GMH-IVH are limited. Stem cell-based therapies offer a potential therapeutic approach to repair, restore, and/or regenerate injured brain tissue. These preclinical findings have now culminated in ongoing human neonatal stud
BACKGROUND: Insulin-like growth factor 1 (IGF-1) is a mitogenic hormone involved in many processes such as growth, metabolism, angiogenesis and differentiation. After very preterm birth, energy demands increase while maternal supplies of nutrients and other factors are lost and the infant may become dependent on parenteral nutrition for weeks. Low postnatal IGF-1 concentrations in preterm infants
Postnatal growth from birth up to 7 y of age was evaluated in 151 children with varying degrees of intrauterine growth retardation who were previously examined in their intrauterine life with Doppler velocimetry of the thoracic descending aorta. The children with abnormal fetal aortic blood flow class (BFC), of which 39/46 (85%) had a birthweight > or = 2 SD below the mean of the population, were
This study found that two casein hydrolysate formulas varying in composition were equally effective in managing colicky symptoms associated with protein sensitivity. Both hydrolysate formulas were associated with a significant, comparable reduction in crying duration and intensity from baseline in 15 of 22 infants with complete data. Subsequent challenge data suggest that the population studied we
