Evaluation of the LacO/LacR Tethering Method Coupled to a High Content Analysis: Study of the in vivo Interaction Between the NuRD Complex and the Transcription Factor MITF in Human Melanoma
Mammalian cells are frequently under stress leading to DNA damage because of UV exposure, ionizing radiation or genotoxic chemicals. Cells have evolved a DNA damage response (DDR) mechanism to ensure survival and pass on the correct genetic information to the next generation. MITF is a melanocyte-specific transcription factor. It has been shown to accumulate in the vicinity of DNA damage and its e
