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Research priorities for HIV/M. tuberculosis co-infection

This document summarizes priority areas for joint research and concerted actions to counteract the public health threat of AIDS/TB as identified within the European Support Action "EUCO-Net" funded under the 7th Framework Programme of the European Commission.

Antiretroviral resistance at virological failure in the NEAT 001/ANRS 143 trial: Raltegravir plus darunavir/ritonavir or tenofovir/emtricitabine plus darunavir/ritonavir as first-line ART

Objectives: To describe the pattern of drug resistance at virological failure in the NEAT001/ANRS143 trial (first-line treatment with ritonavir-boosted darunavir plus either tenofovir/emtricitabine or raltegravir). Methods: Genotypic testing was performed at baseline for reverse transcriptase (RT) and protease genes and for RT, protease and integrase (IN) genes for patients with a confirmed viral

Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy

OBJECTIVES: Deficits in cognitive function remain prevalent in HIV-infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)-naïve HIV-infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study.METHODS: Prior to starting ART, seven cognitive tes

Sex Workers' Rights Movement And The EU : Challenging The European Prostitution Policy Model

This chapter analyses relations and interactions among civil society organisations active at the European Union level in the prostitution policy area, which is characterised by opposite frames regarding prostitution as work, sex or violence. The study draws on the theoretical perspective of Strategic Action Fields, focuses on the International Committee on the Rights of Sex Workers in Europe (ICRS

Untangling Cortico-Striatal Connectivity and Cross-Frequency Coupling in L-DOPA-Induced Dyskinesia

We simultaneously recorded local field potentials (LFPs) in the primary motor cortex and sensorimotor striatum in awake, freely behaving, 6-OHDA lesioned hemi-parkinsonian rats in order to study the features directly related to pathological states such as parkinsonian state and levodopa-induced dyskinesia. We analyzed the spectral characteristics of the obtained signals and observed that during dy

TuneR: A Framework for Tuning Software Engineering Tools with Hands-on Instructions in R

Numerous tools automating various aspects of software engineering have been developed, and many of the tools are highly configurable through parameters. Understanding the parameters of advanced tools often requires deep understanding of complex algorithms. Unfortunately, suboptimal parameter settings limit the performance of tools and hinder industrial adaptation, but still few studies address the

Model for individual prediction of diabetes up to 5 years after gestational diabetes mellitus

AIMS: To identify predictors of diabetes development up to 5 years after gestational diabetes mellitus (GDM) and to develop a prediction model for individual use.METHODS: Five years after GDM, a 75-g oral glucose tolerance test (OGTT) was performed in 362 women, excluding women already diagnosed with diabetes at 1- to 2-year follow-up or later (n = 45). All but 21 women had results from follow-up

Falsified Medicines : Literature review

In order to understand the global phenomenon of falsified medicines, this literature review is conducted as a pilot study to identify knowledge gaps and deliver insights for further research. The emergence and prevalence of falsified medicines takeon different forms between developing and developed nations due to political, economic, social and culturalfactors, yet studies from social, historical,

Evaluating a quantitative IT maturity self-assessment approach: Does it give a good way of the as-is state?

It has become increasingly recognized that IT organizations must ensure that IT services are aligned to business needs and actively support them. Therefore, the internal IT service management processes are under constant improvement. Information Technology Infrastructure Library (ITIL) is the most commonly adopted framework for IT service management. The recommendation is to start an ITIL implemenIt has become increasingly recognized that IT organizations must ensure that IT services are aligned to business needs and actively support them. Ther efore, the internal IT service management processes are under constant improvement. Information Technology Infrastructure Library (ITIL) is the most commonlyadopted framework for IT service management. The r ecommendation is to start an ITIL impleme

Synthesis of high-quality, well-characterized CaAlFe-layered triple hydroxide with the combination of dry-milling and ultrasonic irradiation in aqueous solution at elevated temperature

The combination of mechanochemical and ultrasonic treatment was applied to synthesize CaAlFe-layered triple hydroxides with carbonate or chloride anions in the interlamellar space. The optimal parameters of the preparation were explored by altering the initial ratio of the metal ions and the temperature of ultrasonic irradiation. The resulting triple hydroxides were characterized by X-ray diffract

Mechanochemical synthesis and intercalation of Ca(II)Fe(III)-layered double hydroxides

A mechanochemical method (grinding the components without added water - dry grinding, followed by further grinding in the presence of minute amount of water or NaOH solution - wet grinding) was used in this work for the preparation and intercalation of CaFe-layered double hydroxides (LDHs). Both the pristine LDHs and the amino acid anion (cystinate and tyrosinate) intercalated varieties were prepa

Mn(II)-amino acid complexes intercalated in CaAl-layered double hydroxide - Well-characterized, highly efficient, recyclable oxidation catalysts

Intercalated composite materials were prepared with CaAl-layered double hydroxide as the host and Mn(II)-amino acid (l-cysteine, l-histidine and l-tyrosine) complex anions as the guest. Two methods (intercalation of the ligand first followed by constructing the complex; preforming the complex first, then introducing it among the layers of the host) and optimization of the auxiliary conditions were