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Anticoagulation control in Sweden: reports of time in therapeutic range, major bleeding, and thrombo-embolic complications from the national quality registry AuriculA.

Aims In anticoagulation treatment with warfarin, the risk of thrombo-embolic events must be weighed against the risk of bleeding. Time in therapeutic range (TTR) is an important tool to assess the quality of anticoagulation treatment, and has been shown to correlate with less bleeding and thrombo-embolic complications. AuriculA, the Swedish national quality registry for atrial fibrillation and ant

The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension.

OBJECTIVE: We tested whether two single-nucleotide polymorphisms (SNPs) (rs2383207 and rs10757278), previously strongly associated with myocardial infarction, are independently associated with stroke and coronary events in patients with hypertension. METHODS: The Nordic Diltiazem study compared the effects of calcium antagonist and beta-blocker or diuretic-based antihypertensive treatment on cardi

Environmental factors and testicular function.

Over the last decades there has been a dramatic increase in the incidence of some diseases associated with the male reproductive system, including poor semen quality, testicular cancer and congenital developmental abnormalities such as cryptorchidism and hypospadias, malformations of the urethra and scrotum respectively. Based on these observations one recurring theme is the concern that certain e

A Stochastic Optimal Power Flow Problem With Stability Constraints - Part I: Approximating the Stability Boundary

Stochastic optimal power flow can provide the system operator with adequate strategies for controlling the power flow to maintain secure operation under stochastic parameter variations. One limitation of stochastic optimal power flow has been that only line flows have been used as security constraints. In many systems voltage stability and small-signal stability also play an important role in constrai

Lundbystudien har uppdaterats med ny fältundersökning. Unikt projekt tyder på att den psykiska ohälsan inte ökat de senaste 50 aren.

The Lundby study is a classic epidemiological investigation. The first field investigation took place in the parishes of Dalby and Bonderup in 1947. The Lundby population, consisting of 3563 probands, was investigated for the fourth time in 1997 -2000 by Per Nettelbladt and his research team. Previous investigations took place in 1947, 1957, and 1972. Several sources of information have been used,

Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways.

Cystatin C is believed to prevent tumor progression by inhibiting the activities of a family of lysosomal cysteine proteases. However, little is known about the precise mechanism of cystatin C function in prostate cancer. In the present study, we examined the expression of cystatin C and its association with matrix metalloproteinases 2 (MMP2) and androgen receptor (AR) in a tissue microarray compa

Early rheumatoid arthritis and body composition.

Objectives. RA is associated with joint destruction and cardiovascular diseases (CVDs). Possible predictors for CVD are early changes in body composition. We therefore evaluated whether lean mass of arms and legs (LMAL), total body fat mass (BFM) or truncal fat distribution (TFD) are altered early in RA, and if so, which factors are associated. Methods. We included 132 RA patients (95 women) with

Grevens minnesmärken

The Counts memorials: A short presentation and interpretation of a number of memorials erected by the count Per Brahe junior between 1653 and 1680 on Visingsö and in Skärstad in Småland, at Dimbo in Västergötland and Östra Ryd in Uppland.