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Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator Lysine-specific histone demethylase 1A (LSD1) induces a rapid expansion of human cord blood derived CD34+ cells and promotes in vitro propagation of long-term repopulating HSCs by preventing differentiation. The phenot
Single drop breakup visualizations are the golden standard for experimentally measuring breakup frequency, g, in turbulent flows. There is a growing demand for empirically obtained breakup frequencies, for population balance equation (PBE) based predictive modelling and for comparing to theoretical suggestions. However, five different methods to estimate g from a breakup visualization can be found
A general goal in community ecology and evolutionary biology is to understand how diversity has arisen. In our attempts to reach such goals we become increasingly aware of interacting ecological and evolutionary processes shaping biodiversity. Ecological opportunity and adaptive radiations can, for example, drive diversification in competitive communities but little is known about how such process
Mercury is, because of its high vapor pressure and its prevalence in the atmosphere as atoms, an interesting geophysical tracer gas, also with potential archaeological applications. According to historical records dating back 2200 years, the mausoleum chamber of the “Terracotta Army Emperor” Qin in Xi´an, China, contains large amounts of liquid mercury, considered as an elixir of life at the time.
The outcome of periampullary adenocarcinomas remains poor with few treatment options. Podocalyxin-like protein (PODXL) is an anti-adhesive protein, the high expression of which has been shown to confer a poor prognosis in numerous malignancies. A correlation and adverse prognostic synergy between PODXL and the epidermal growth factor receptor (EGFR) has been observed in colorectal cancer. Here, we
The Klotho (KL) gene is involved in phosphate homeostasis. Polymorphisms in this gene have been reported to be associated with the risk of cardiovascular disease. Here we used computational tools to predict the damage-associated single nucleotide polymorphisms (SNPs) in the human KL gene. We further investigated the association of SNPs in the KL gene and mortality in the Swedish multicenter prospe
Modeling criteria interaction in decision-making problems is complex and often neglected. In complicated problems, like contaminated site remediation projects, independency of involved criteria is not a realistic assumption. INfluence based deciSIon guiDE (INSIDE) is a methodology that enables sustainable decision making and management in contaminated site remediation practice. Unlike most previou
Wind turbines have considerable impact on flying animals, particularly bats, which are sometimes killed in large numbers by the moving rotors. A longstanding question remains why bats are attracted to wind turbines and risk their lives among the moving rotor blades. One hypothesis is that they feed on insects swarming around the turbine towers and another is that they congregate there to court. Th
This paper presents a large eddy simulation of n-heptane/air turbulent premixed combustion in a reactor assisted turbulent slot (RATS) burner under different preheating conditions. N-heptane/air mixture at an equivalence ratio of 0.6, pressure of 1 atm and temperature of 600, 650 and 700 K is considered to investigate the effect of low temperature chemistry on turbulent burning velocities and flam
Non-coagulating milk is unwanted in cheese production because it impairs chymosin-induced coagulation properties in bulk milk. Milk samples were analysed to investigate the coagulation process in non-coagulating milk for comparison with milk samples that have a high coagulation ability. This was done by measuring two peptides after chymosin cleavage, namely para-κ-casein and caseinomacropeptide, i
An innovative alternating V-rows triangular tube layout was devised for the twisted elliptical tube heat exchangers to enhance heat transfer between adjacent tubes. Under the same tube circumference, altogether eleven twisted elliptical tube heat exchangers with two tube layouts, diverse aspect ratios of twisted elliptical tubes and different twisted pitches were constructed and simulated, includi
Technological and policy solutions for transitioning to a fossil-free society exist, many countries could afford the transition, and rational arguments for rapid climate action abound. Yet effective action is still lacking. Dominant policy approaches have failed to generate action at anywhere near the rate, scale or depth needed to avoid potentially catastrophic futures. This is despite 30 years o
Groundwater (GW) resources provide a large share of the world's water demand for various sections such as agriculture, industry, and drinking water. Particularly in the arid and semi-arid regions, with surface water scarcity and high evaporation, GW is a valuable commodity. Yet, GW data are often incomplete or nonexistent. Therefore, it is a challenge to achieve a GW potential assessment. In this
The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally unknown. Here, the immune landscape of ASCL1-positive lung adenocarcinomas was characterized by immunohistochemistry. Furthermore, ASCL1
Energy dispersive x-ray spectroscopy in a transmission electron microscope is often the first method employed to characterize the composition of nanowires. Ideally, it should be accurate and sensitive down to fractions of an atomic percent, and quantification results are often reported as such. However, one can often get substantial errors in accuracy even though the precision is high: for nanowir
Neuropsychiatric disturbances with altered social cognition, depression and anxiety are among the most debilitating early features in the fatal neurodegenerative disorder Huntington disease (HD) which is caused by an expanded CAG repeat in the huntingtin gene. The underlying neurobiological mechanisms are not known. Neuropathological analyses of postmortem human HD hypothalamic tissue have demonst
This study aims to enhance our understanding of organizational identity work (OIW), building upon previous studies’ emphasis on the usefulness of understanding OIW in terms of storytelling. The paper offers an extended vocabulary for making sense of alternative narration forms. Based on an in-depth study of a humanitarian organization in Sweden, the discursive OIW struggles of employees in times o
Purpose: To report a severe phenotype of retinitis pigmentosa associated with novel mutations in CNGB1. Observations: Six siblings, age range 50–75 years old, were examined using optical coherence tomography and fundus autofluorescene, electroretinogram testing, Goldman visual field testing, and genetic testing using next generation sequencing. In four affected siblings, two novel compound heteroz
Introduction: Preeclampsia (PE) is a human specific pregnancy-related syndrome of unknown etiology that affects 2–8 % of pregnancies. Polymorphism in maternal Killer Cell Immunoglobulin-like Receptors (KIRs) and the ligand fetal Human Leukocyte Antigen-C (HLA-C) may predispose pregnant mothers for PE due to defective trophoblast invasion into the maternal decidua. Our study aimed to investigate th
The functional trait framework provides a powerful corpus of integrated concepts and theories to assess how environmental factors influence ecosystem functioning through community assembly. While common in plant ecology, this approach is under-used in microbial ecology. After an introduction of this framework in the context of microbial ecology and enzymology, we propose an approach 1) to elucidat
