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Soluble guanylyl cyclase (sGC) is an effector enzyme of nitric oxide (NO). Recent work has unravelled how levels of this enzyme are controlled, and highlighted a role in vascular disease. We provide a timely summary of available knowledge on transcriptional regulation of sGC, including influences from the NOTCH signalling pathway and genetic variants. It is speculated that hypertension-induced rep

Additive manufacturing and its related techniques have frequently been put forward as a promising candidate for planetary in-situ manufacturing, from building life-sustaining habitats on the Moon to fabricating various replacements parts, aiming to support future extra-terrestrial human activity. This paper investigates the mechanical behaviour of lunar regolith simulant material components, which

BACKGROUND: Sense of Coherence (SOC) is important for successful adaptation and mental well-being in people with life-long medical conditions. Late effects of polio (LEoP) often lead to a life-long disability, but no study has assessed SOC in this population. OBJECTIVE: To assess SOC in persons with LEoP and to explore the association between SOC, demographics (age, gender, marital status and leve

Pharmacotherapy of epilepsy is usually initiated after two or more unprovoked seizures, a decision that should be made after assessment of the individual risk of further seizures. Antiepileptic drugs (AEDs) are selected based on documented efficacy for the type of seizures, the epilepsy and possible epilepsy syndrome of the patient, taking potential adverse effects and comorbidity into account. Fo

Innovation auditing is a well-established practice used by managers to identify strengths and weaknesses in innovation. Existing audit frameworks fall short, however, because they neglect three major trends that currently transform the innovation landscape. These trends are as follows: 1) a shift from closed to more open models of innovation (“openness”), 2) a shift from providing physical product

The effect of the support material and chemical state of Rh in Rh/A2O3 and Rh/SiO2 model catalysts during CO2 hydrogenation were studied by a combined array of in situ characterisation techniques including diffuse reflectance infrared Fourier transform spectroscopy, energy-dispersive X-ray absorption spectroscopy and high-energy X-ray diffraction at 250-350 °C and atmospheric pressure. CO2 methana

Cardiac resynchronization therapy (CRT) has proven prognostic benefits in patients with heart failure (HF) with left bundle branch block (LBBB) QRS morphology. Electrocardiographic left atrial (LA) abnormality has been proposed as a noninvasive marker of atrial remodeling. We aimed to assess the impact of electrocardiographic LA abnormality for prognosis in patients with HF treated with CRT. Basel

The aim of this work is to study the performance of nanoporous carbon membrane for hydrogen recovery from off-gas streams. The study is based on a rigorous mathematical model which can predict the performance of nanoporous selective surface flow (SSF) carbon membrane. Basically, the developed model is based on two transport mechanisms: the dusty gas flow through porous media and the surface adsorp

To mimic the active sites of the hydrolytic enzyme zinc phosphotriesterase, a new dinucleating unsymmetric ligand, PICIMP (2-([2-hydroxy-5-methyl-3-(([(1-methyl-1H-imidazol-2-yl)methyl](pyridin-2-ylmethyl)amino)methyl)benzyl][(1-methyl-1H-imidazol-2-yl)methyl]amino)acetic acid), has been synthesized and characterized. The hydrolytic efficacy of the complex solution (PICIMP/ZnCl2 = 1:2) has been in

Early life environments shape phenotypic development in important ways that can lead to long-lasting effects on phenotype and fitness. In reptiles, one aspect of the early environment that impacts development is temperature (termed 'thermal developmental plasticity'). Indeed, the thermal environment during incubation is known to influence morphological, physiological, and behavioral traits, some o

Advances in information technology are increasing the use of radar as a tool to investigate and monitor bird migration movements. We set up a field campaign to compare and validate outputs from different radar systems. Here we compare the pattern of nocturnal bird migration movements recorded by four different radar systems at a site in southern Sweden. Within the range of the weather radar (WR) Ä

The possibility of precipitating high molecular weight (MW) softwood hemicelluloses has been investigated. Solids were precipitated from a sodium-based spent sulfite liquor with the anti-solvents acetone, ethanol and methanol and the effects of solute concentration, pH and temperature on the precipitation were studied. The product yield, degree of separation, MW and structure of the different frac

Fire at the dry southern margin of the Amazon rainforest could have major consequences for regional soil carbon (C) storage and ecosystem carbon dioxide (CO2) emissions, but relatively little information exists about impacts of fire on soil C cycling within this sensitive ecotone. We measured CO2 effluxes from different soil components (ground surface litter, roots, mycorrhizae, soil organic matte

Under 2016 genomförde Svenska kyrkans forskningsenhet ett teologiskt aktionsforskningsprojekt med Mölndals pastorat. Utgångspunkten var erfarenheter från ett transitboende flyktingbarn som drevs i kommunal regi i församlingens lokaler. Detta är den andra av två artiklar (se även Svensk kyrkotidning nr 9, 2017)

Retail and cities have had a long and intertwined history together. Since the beginning of first cities established, being a hub for commercial exchange has been one of the main elements what makes a city (Söderlind, 2011). Nevertheless, since 1980s, there have been some substantial shifts at the global scale regarding the organization of retail, and in turn, its spatial manifestations in the citi

The accurate reproduction of the spatial and temporal dynamics of marine benthic biodiversity requires the development of mechanistic models, based on the processes that shape macroinvertebrate communities. The modelled entities should, accordingly, be able to adequately represent the many functional roles that are performed by benthic organisms. With this goal in mind, we applied the emergent gro

In order to better understand and predict the dynamics of benthic macroinvertebrate communities, we need to first define the functional components of benthic biodiversity and then provide a mechanistic description of how they interact with their abiotic environment, their basic resources and each other. These interactions should be largely controlled by readily available biological traits, making

The conspicuous retreat of the key species Fucus vesiculosus from the deeper parts of its former distribution area in the Baltic Sea has triggered extensive research on the factors that control its growth. Based on recently obtained knowledge on a large number of potential drivers, we developed a numerical model incorporating effects of abiotic factors on the physiological functions of photosynthe