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Limited and poor delivery of antibiotics is cited as one reason for the difficulty in treating antibiotic-resistant biofilms associated with chronic infections. We investigate the effectiveness of a positively charged, single isomer cyclodextrin derivative, octakis[6-(2-aminoethylthio)-6-deoxy]-γ-CD (γCys) to improve the delivery of antibiotics to biofilms. Using multiphoton laser scanning microsc
OBJECTIVES: This study investigates the expansion of CAR T-cells and its association to treatment outcome.METHODS: Patients with aggressive B-cell lymphomas treated with anti-CD19 CAR T-cell therapy axicabtagene ciloleucel (axi-cel) at Skåne and Sahlgrenska University Hospitals from 2019 to October 2024 were included. CAR T-cells in peripheral blood were measured by flow cytometry. Association bet
Den pågående energiomställningen har inneburit en överhalning av både policy och infrastruktur. Medan beslutsfattare och industrin letar efter nya tillvägagångssätt för att tackla alltmer växande problem som klimatomställningar, resiliens och energifattigdom, är sektorn under total transformation. Det finns en ökad medvetenhet om att energisektorn inte bara består av teknik, utan också av människoDen pågående energiomställningen har inneburit en överhalning av både policy och infrastruktur. Medan beslutsfattare och industrin letar efter nya tillvägagångssätt för att tackla alltmer växande problem som klimatomställningar, resiliens och energifattigdom, är sektorn under total transformation. Det finns en ökad medvetenhet om att energisektorn inte bara består av teknik, utan också av människo
In the New Testament gospel accounts of the empty tomb, there is a strong emphasis on vision and sight. This emphasis is at times understood as a reference to the role of eyewitnesses and their testimonies in the formation of the gospel tradition. This study, however, reads the visual elements of the texts as part of their poetics, as part of their narrative and rhetorical setting.By looking at ei
This paper introduces an addressability logic for crafting research contributions to advance scientific and societal impact in marketing and consumer research. For research to be meaningful we ask: for whom? Using rhetorical audience analysis, we examine 80 interpretivist articles in four journals over twenty years to identify their intended addressees. We identify four audience categories along aThis paper introduces an addressability logic for crafting research contributions to advance scientific and societal impact in marketing and consumer research. For research to be meaningful we ask: for whom? Using rhetorical audience analysis, we examine 80 interpretivist articles in four journals over twenty years to identify their intended addressees. We identify four audience categories along a
Jag undersöker den ideala krigar-mannen i två av Gamla testamentets profetböcker: Jesaja och Jeremia. Här beskrivs han som misslyckad och sårbar och i metaforer liknas han till exempel vid en kvinna som föder barn. Under perioden för böckernas tillkomst inträffade en katastrof för folket i Juda, den babyloniska exilen innebar att landet erövrades av stormakten Babylonien och att delar av folket tThis book explores how the prophets Isaiah and Jeremiah depict warriors as vulnerable. In the oracle sections of these prophetic books, vivid imagery shows the warriors failing—not only in their duties as mighty men—but also in living up to the expectations of militarised masculinity. They are presented through imagery of cowardice, weakness, pain, and fear and are often portrayed as women, partic
The conservation community sorely lacks a global indicator of change in insect populations. Given widespread insect declines, addressing this gap is key for conservation and policy targets. We suggest that butterfly monitoring programs can serve as the foundation for an effective global network of insect monitoring. To assess this potential, we bring together an international consortium and calcul
We provide evidence of a positive association between independent directors’ reputation incentives and the magnitude of the CEO pay gap, defined as the difference in compensation between the CEO and lower-ranked executives. The CEO pay gap serves as a proxy for the strength of executive pay tournaments within the firm. Using a sample of S&P 1500 firms, we show that independent directors with s
Accurate and continuous monitoring of inland surface water dynamics is vital for sustainable water resource management, climate impact assessment, and ecological planning. This study introduces a machine learning-based remote sensing-based data-fusion framework that improves Sentinel-3 radar altimeter (SRAL) estimations of water surface elevation (WSE) by integrating ERA5 reanalysis climate varia
Polar growth and cell shape determination in mycelium-forming Streptomyces bacteria depends on the function of a polarly localised multiprotein complex that directs cell wall synthesis – the polarisome. This complex assembles around the essential cell polarity determinant DivIVA, alongside other largely unknown components. We report here the discovery of a conserved hybrid histidine kinase-like pr
Fibroblasts are dynamic structural cells that direct both beneficial tissue repair and pathological organ fibrosis through interactions with tissue-resident type 2 lymphocytes (T2Ls) and type 3/17 lymphocytes (T3Ls). The cytokines interleukin-13 (IL-13) and IL-17A, produced by T2Ls and T3Ls, respectively, are linked to both tissue inflammation and fibrosis, but how their spatial positioning influe
The Binarity at LOw Metallicity (BLOeM) survey is an ESO large programme designed to obtain multi-epoch spectroscopy for 929 massive stars in the Small Magellanic Cloud (SMC). It will provide binary fractions and orbital configurations of binary systems and search for dormant black hole binary candidates (OB+BH). We present projected rotational velocities (v sin i) of all sources, and, using the m
Introduction: Exposure to high acoustic noise levels generated during 7 Tesla (T) magnetic resonance imaging (MRI) may affect auditory function. To better understand these effects, this study examines how such noise exposure influences outer hair cell function in healthy adults, with a focus on the efficiency of a dual hearing protection method. Methods: In this within-subjects longitudinal study,
Growth and immune development—fundamental parts of any organism's ontogeny—depend critically on nutrient availability, particularly on essential amino acids that support protein synthesis and physiological processes. However, environmental variation can reduce prey diversity and nutrient quality, producing suboptimal diets that lack essential amino acids, potentially constraining development. In t
The Bcl-2 family of proteins governs mitochondrial outer membrane (MOM) permeabilization, a critical step in apoptosis that is dysfunctional in many cancers. Although cellular studies have long implicated direct interactions between the pore-forming apoptotic Bax protein and its opponent, the antiapoptotic Bcl-2 protein in apoptosis regulation, the underlying basic principles behind this control r
Rapid adoption of artificial intelligence methods in breast imaging research emphasizes the need for large, appropriately curated image databases for development and validation. For digital breast tomosynthesis (DBT), there are few public databases with only limited lesion annotation. Recently, we have developed Malmö Breast ImaginG (M-BIG), a large database of 104 791 women screened at Skåne Univ
More than six decades ago, Aníbal Pinto Santa Cruz (1959) published his pivotal work, Chile, a case of frustrated development. Almost 65 years later, this concept has been reborn under the massive protests and social unrest of 2019, the COVID pandemic, and the new lithium cycle. Chile, the former “Latin American Miracle,” has become an unstable and troublesome state, not particularly different fro
Molecular oxygen activation at single transition metal atom sites is critical for catalysis but remains challenging to control. Here we investigate a manganese–cobalt bi-metallic coordination network on graphene, where Co(i) atoms are tetracoordinated by nitrogen. Combining density functional theory with in situ infrared-visible sum-frequency generation and ambient-pressure X-ray photoelectron spe
