Search results

Filter

Filetype

Your search for "*" yielded 547517 hits

DNA digestion and formation of DNA-network structures with Holliday junction-resolving enzyme Hjc_15-6 in conjunction with polymerase reactions

The recently identified novel Holliday junction-resolving enzyme, termed Hjc_15-6, activity investigation results imply DNA cleavage by Hjc_15-6 in a manner that potentially enhances the molecular self-assembly that may be exploited for creating DNA-networks and nanostructures. The study also demonstrates Pwo DNA polymerase acting in combination with Hjc_15-6 capability to produce large amounts of

Cloning and Characterization of a Novel N-Acetyl-D-galactosamine-4-O-sulfate Sulfatase, SulA1, from a Marine Arthrobacter Strain

Sulfation is gaining increased interest due to the role of sulfate in the bioactivity of many polysaccharides of marine origin. Hence, sulfatases, enzymes that control the degree of sulfation, are being more extensively researched. In this work, a novel sulfatase (SulA1) encoded by the gene sulA1 was characterized. The sulA1-gene is located upstream of a chondroitin lyase encoding gene in the geno

Minimal invasive LASER-resection vs. radiotherapy as primary treatment of early glottic cancer. A population-based study with, up to 16 years follow up of survival, rate of laryngectomy and voice function

BACKGROUND: Early glottic cancer can be treated with laser resection or radiotherapy. In an earlier study, we found that voice function after laser resection was inferior to that after radiotherapy.OBJECTIVES: This study was designed to determine if reduced margins at laser resection improved voice function without impairing oncologic results.METHOD: A total of 268 patients with previously untreat

Operator gender differences in major mechanical complications after central line insertions : a subgroup analysis of a prospective multicentre cohort study

BACKGROUND: A previous study on mechanical complications after central venous catheterisation demonstrated differences in complication rates between male and female operators. The objective of this subgroup analysis was to further investigate these differences. The hypothesis was that differences in distribution of predefined variables between operator genders could be identified.METHODS: This was

Effect of kilning on the macronutrient composition profile of three Swedish oat varieties

Background and ObjectivesKilning is crucial in oat processing, to prevent rancidity and extend shelf-life. This study examines kilning effects on the macronutrient composition in Swedish oat varieties Galant, Fatima, and Belinda. We compared two kilning methods: one mimicking industrial practice and a simplified version. We analyzed dietary fibers (arabinoxylan, β-glucan), protein and amino acids,

Astrobiology as Science

“Astrobiology as science” refers to how astrobiology is characterized and discussed in the philosophy of science.

Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

Peripheral T cell lymphomas are typically aggressive with a poor prognosis. Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells limits the efficacy of immunotherapeutic approaches. The T cell receptor expresses one of two highly homologous chains [T cell receptor β-chain constant (TRBC) domains 1 and 2] in a mutually exclusive manner, mak

Musk Fights Sweden’s Unions

OPINION He refuses to enter into the collective wage agreements that define the West’s most corporatist economy.

No title

During the 18th century, collections of coins and medals were familiar sights. The collectors ranged from scholars to amateurs, men and women and the collectables tempted collectors for various reasons: they signified wealth and knowledge, they rendered historical events or current politics in material form, or they were miniature artworks and financial investments. Also, the visual and material c

Will the Center Hold? What Research Centers Do to Universities and to Societal Challenges

Research centers represent a specific organizational format for linking the traditional university organization with external actors, goals, and processes in time-limited, concentrated efforts of research and collaboration. Yet, the center format contains large variations, and centers act as interfaces between university organizations, societal actors, and research funders in multifaceted ways. In

Carrier Cooling in Lead Halide Perovskites : A Perspective on Hot Carrier Solar Cells

The concept of hot carrier solar cells (HCSCs) has been proposed as a promising yet elusive path toward high-performance photovoltaics (PV), capable of surpassing the Shockley-Queisser limit by recycling energy that would otherwise be lost during thermalization. Lead halide perovskites (LHPs) have emerged as highly promising materials for PV applications. The reports of slow hot carrier (HC) cooli

Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen : patient-level meta-analysis of randomised trials

BACKGROUND: As trials of 5 years of tamoxifen in early breast cancer mature, the relevance of hormone receptor measurements (and other patient characteristics) to long-term outcome can be assessed increasingly reliably. We report updated meta-analyses of the trials of 5 years of adjuvant tamoxifen.METHODS: We undertook a collaborative meta-analysis of individual patient data from 20 trials (n=21,4

Damage Analysis of Reactive Ion and Quasi-Atomic Layer Etched Silicon

Atomic layer etching (ALE) is a cyclic technique based on self-limiting processes, such as reactive gas adsorption and material removal by low-energy ion bombardment 1,2. In a typical ALE process Ar+ ions with energies of 20-60 eV are used to desorb the reaction products, e.g. SiClx for the Si ALE. Compared to a corresponding continuous reactive ion etching (RIE), where the ion energies often exce