The differentiation of human pluripotent stem cells into ventral mesencephalic dopaminergic (DA) fate is relevant for the treatment of Parkinson's disease. Shortcuts to obtaining DA cells through direct reprogramming often include forced expression of the transcription factor LMX1A. Although reprogramming with LMX1A can generate tyrosine hydroxylase (TH)-positive cells, their regional identity rem

My written contribution responds to the questions: How des your practice relate to placemaking? How is it possible to use sense of place as material and starting point for research or artistic work? What methods do you use for co-creation and relationship building in relation to place?

Objectives: Variation exists in the capabilities of electronic healthcare records (EHRs) systems and the frequency of their use by primary care physicians (PCPs) from different settings. We aimed to examine the factors associated with everyday EHRs use by PCPs, characterise the EHRs features available to PCPs, and to identify the impact of practice settings on feature availability. Study design: C

Incompleteness, that is, a feeling that things are “not just right”, is an understudied symptom of obsessive-compulsive disorder (OCD). We used data from 167 adult individuals with OCD who received internet-delivered cognitive behaviour therapy (ICBT) to examine how incompleteness was associated with clinical characteristics and treatment outcomes. Incompleteness was assessed using the Obsessive-C

This paper presents an experimental study on the joint effects of concurrent airflow and sample width on the steady flame spread behaviors. Flame spread parameters, including flame height, preheating length, heat flux distribution, flame spread rate (FSR) and pyrolysis length, were measured and analyzed comprehensively. Results show that the FSR and pyrolysis length increase with sample width and

BACKGROUND: While experimental data suggest that selective intracoronary hypothermia decreases infarct size, studies in patients with ST-elevation myocardial infarction (STEMI) are lacking. AIMS: We investigated the efficacy of selective intracoronary hypothermia during primary percutaneous coronary intervention (PCI) to decrease infarct size in patients with STEMI. METHODS: In this multicentre ra

Background: There are few large register-based studies on people with intellectual disabilities (ID) that compare outcomes with the general population. Methods: All people in Skåne, the southernmost part of Sweden the 1st of January 2014 was included. Data concerning demographics/vital events, healthcare utilization and service and support for people with ID or autism spectrum disorder (ASD) was c

Background: People with intellectual disabilities (ID) experience barriers to health care, which may have been particularly relevant during the Covid-19 pandemic.Methods: In this register-based study, we identified all people living in Skåne (southernmost region of Sweden) on January 1st, 2014. People with ID (F7) or Down Syndrome (Q90), or service and support for people with ID or autism spectrum

Background: People with intellectual disabilities (ID) often have an extensive and complex disease panorama. However, more knowledge is needed about the disease panorama to gain a deeper understanding of co-morbidity and potential care needs.Methods: Among all people living in Skåne on January 1st, 2014, we established a cohort of 14 716 people with ID (either diagnosis of ID (F7) or Down Syndrome

Background: Women with intellectual disability (ID) may encounter barriers to exercising reproductive agency, self-care during pregnancy, and accessing healthcare to optimize pregnancy outcomes. However, there is to date little evidence to guide policy and practice. We aim to fill this identified knowledge gap by examining pregnancy outcomes among women with ID in comparison with women from the ge

In recent years, scholars of migration have created several new immigration policy indexes, but most existing databases have limited temporal scope. They also focus, to a large extent, on the Global North. In this research note, we introduce the Historical Immigration Policy dataset (HIP), which begins to fill these gaps. We first provide an overview of the data and then describe how they offer ne

Can the right requirements boost developer satisfaction and happiness? We believe they can. In keeping with this issue's theme, 'Well-Being for Resilience: Developers Thrive,' we discuss the connection between the three keywords, well-being, resilience, and thriving. How could requirements engineering foster these qualities? While there hasn't been much research on this topic, we see opportunities

Background and objective: There is an unmet need to avoid long-term morbidity associated with standard cytotoxic treatment for low-volume metastatic seminoma. Our aim was to assess the oncological efficacy and surgical safety of retroperitoneal lymph node dissection (RPLND) as treatment in a population-based cohort of metastatic seminoma patients with limited retroperitoneal lymphadenopathy. Metho

De senaste årtiondena har samhället i stort präglats av digitalisering. Så också detaljhandeln, med en växande betydelse av digitala plattformar där människor gör sina vardagsinköp via dator, till alltmer även via mobilen. Avgörande för om människor faktiskt kan genomföra sina köp i detaljhandeln är betalningar. Betalningar har liksom detaljhandeln också blivit mer digitala, med en stadig minskninThis dissertation explores how and why certain payment methods are used in retail.Payment methods have changed in their form throughout history, and rapidly so in recent decades. Surprisingly, the treatment of payment in retail research appears detached from its purpose of use; i.e. purchasing products and services.Payment has a role to play in the digitalisation of society and is part of shaping