BACKGROUND: The filaggrin protein is important for skin barrier structure and function. Loss-of-function (null) mutations in the filaggrin gene FLG may increase dermal absorption of chemicals. OBJECTIVE: The objective of the study was to clarify if dermal absorption of chemicals differs depending on FLG genotype. METHOD: We performed a quantitative real-time polymerase chain reaction (qPCR)-based

An ECG risk-score has been described that predicts high risk of subsequent cardiac arrest in young patients with hypertrophic cardiomyopathy (HCM). Myocardial fibrosis measured by cardiac magnetic resonance (CMR) late gadolinium enhancement (LGE) also affects prognosis. We assessed whether an ECG risk-score could be used as an indicator of myocardial fibrosis or perfusion deficit on CMR in HCM. In

Dissociation of water molecules after soft X-ray absorption can yield neutral fragments in high-Rydberg (HR) states. We have studied the production of such fragments by field ionization and ion time-of-flight (TOF) spectrometry. Neutral HR fragments are created at all resonances below the O 1s ionization potential (IP) and particularly within 1 eV above the O 1s IP. The latter effect is due to the

Motivationk–Top Scoring Pairs (kTSP) algorithms utilize in-sample gene expression feature pair rules for class prediction, and have demonstrated excellent performance and robustness. The available packages and tools primarily focus on binary prediction (i.e. two classes). However, many real-world classification problems e.g., tumor subtype prediction, are multiclass tasks.ResultsHere, we present m

Climate change and human activities influence the development of ecosystems, with human demand of ecosystem services altering both land use and land cover. Fossil pollen records provide time series of vegetation characteristics, and the aim of this study was to create spatially continuous reconstructions of land cover through the Holocene in southern Sweden. The Landscape Reconstruction Algorithm

The Swedish Municipality Act, issued in 1862, consolidated a plutocratic system in which ownership and income, and the resulting level of taxation, translated into political power. However, as a measure to hinder large landowners from holding a majority of the votes, the Act guaranteed voting rights for tenants. The aim of the article is to analyse how power relations played out after this challen

Background: There is a lack of studies of Huntington’s disease (HD) in immigrants. Objective: To study the association between country of birth and incident HD in first-generation immigrants versus Swedish-born individuals and in second-generation immigrants versus Swedish-born individuals with Swedish-born parents. Methods: Study populations included all adults aged 18 years and older in Sweden,

Background: Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and monitor early meniscus degeneration related to knee osteoarthritis. Objective: To investigate MR relaxation times as potential biomarkers for meniscus degeneration through comparison

Purpose: Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir on its quantitative accuracy. Procedures: Two study cohorts with Alzheimer’s dis

For infants and their families, sleep consolidation is important in maturing neural and circadian rhythms, and in family dynamics. The Possums Infant Sleep Program is a cued care approach to infant sleep, responding to infant cues in a flexible manner, dialing down the infant’s sympathetic nervous system. The current study evaluated the effect of the Possums program on infant sleep and breastfeedi

Chemical processing by plasma is utilized in many applications. Plasma-related studies, however, are challenging to carry out due to plasmas' transient and unpredictable behavior, excessive luminosity emission, 3D complexity and aggressive chemistry and physiochemical interactions that are easily affected by external probing. Laser-induced fluorescence is a robust technique for non-intrusive inves

We investigate robustness properties of the Generalized Proportional Allocation (GPA) policy that has been recently proposed for traffic signal control in urban networks. The GPA policy is fully decentralized, relies only on local information on the current congestion state, and requires no knowledge of the routing, the exogenous inflows, or the network structure. In previous work, we proved throu

The asymptotic behaviour of deterministic logit dynamics in heterogeneous routing games is analyzed. It is proved that in directed multigraphs with parallel routes, and in series composition of such multigraphs, the dynamics admits a globally asymptotically stable fixed point. Moreover, the unique fixed point of the dynamics approaches the set of Wardrop equilibria, as the noise vanishes. The resu

We study a robust control problem for dynamical flow networks. In the considered framework, traffic flows along the links of a transportation network —modeled as a capacited multigraph— and queues up at the nodes, whereby control policies determine which incoming queues are to be allocated service simultaneously, within some predetermined scheduling constraints. We first prov

We study the asymptotic behavior of deterministic, continuous-time imitation dynamics for population games over networks. The basic assumption of this learning mechanism --- encompassing the replicator dynamics --- is that players belonging to a single population exchange information through pairwise interactions, whereby they get aware of the actions played by the other players and the correspond

The FBI recently arrested an Iranian academic for failing to register as a foreign agent in accordance with the Foreign Agents Registration Act. Kaveh Afrasiabi was arrested in Massachusetts and is believed to have received more than $250,000 from the Iranian regime to disseminate its propaganda in the guise of objective analysis. Iranian agent-scholars are easy to recognize: they always oppose th